Skip to main content
Erschienen in: Neuroradiology 7/2008

01.07.2008 | Interventional Neuroradiology

Curative embolization of cerebral arteriovenous malformations (AVMs) with Onyx in 101 patients

verfasst von: Vasilios Katsaridis, Chrysanthi Papagiannaki, Enrico Aimar

Erschienen in: Neuroradiology | Ausgabe 7/2008

Einloggen, um Zugang zu erhalten

Abstract

Introduction

Onyx has emerged in the recent years as a new embolic material. We present our experience with Onyx in the curative embolization of brain cerebral arteriovenous malformations (AVMs).

Methods

We retrospectively reviewed the files of all patients that we had treated with Onyx embolic material for a brain AVM during the last 4 years. We identified 101 patients who underwent a total of 219 sessions of embolization.

Results

The treatment has been concluded in 52 patients; in this group, total occlusion was obtained in 28 (53.9%) patients and near-total occlusion was obtained in 18 (34.6%). The respective figures based on the 101 patients of the study cohort are 28/101 (27.7%) and 18/101 (17.8%). More embolization sessions are to be carried out on the remaining 49 patients. There were three deaths, and eight patients had permanent neurological deficits with a resulting morbidity of 8% and mortality of 3%.

Conclusion

High rates of total or near-total occlusion of brain AVMs can be achieved with multiple sessions of Onyx embolization with acceptable morbidity and mortality
Literatur
1.
Zurück zum Zitat Brothers MF, Kaufmann JC, Fox AJ et al. (1989) n-Butyl 2-cyanoacrylate-substitute for IBCA in interventional neuroradiology: histopathologic and polymerization time studies. AJNR Am J Neuroradiol 10:777–786PubMed Brothers MF, Kaufmann JC, Fox AJ et al. (1989) n-Butyl 2-cyanoacrylate-substitute for IBCA in interventional neuroradiology: histopathologic and polymerization time studies. AJNR Am J Neuroradiol 10:777–786PubMed
2.
Zurück zum Zitat Yamashita K, Taki W, Iwata H et al. (1994) Characteristics of ethylene vinyl alcohol copolymer (EVAL) mixtures. AJNR Am J Neuroradiol 15:1103–1105PubMed Yamashita K, Taki W, Iwata H et al. (1994) Characteristics of ethylene vinyl alcohol copolymer (EVAL) mixtures. AJNR Am J Neuroradiol 15:1103–1105PubMed
3.
Zurück zum Zitat Henkes H, Nahser HC, Berg-Dammer E et al. (1998) Endovascular therapy of brain AVMs prior to radiosurgery. Neurol Res 20:479–492PubMed Henkes H, Nahser HC, Berg-Dammer E et al. (1998) Endovascular therapy of brain AVMs prior to radiosurgery. Neurol Res 20:479–492PubMed
4.
Zurück zum Zitat Jafar JJ, Davis AJ, Berenstein A et al. (1993) The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations. J Neurosurg 78:60–69PubMed Jafar JJ, Davis AJ, Berenstein A et al. (1993) The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations. J Neurosurg 78:60–69PubMed
5.
Zurück zum Zitat Murayama Y, Vinuela F, Ulhoa A et al. (1998) Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile. Neurosurgery 43:1164–1175PubMedCrossRef Murayama Y, Vinuela F, Ulhoa A et al. (1998) Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile. Neurosurgery 43:1164–1175PubMedCrossRef
6.
Zurück zum Zitat Paulsen RD, Steinberg GK, Norbash AM et al. (1999) Embolization of rolandic cortex arteriovenous malformations. Neurosurgery 44:479–484PubMedCrossRef Paulsen RD, Steinberg GK, Norbash AM et al. (1999) Embolization of rolandic cortex arteriovenous malformations. Neurosurgery 44:479–484PubMedCrossRef
7.
Zurück zum Zitat Jahan R, Murayama Y, Gobin YP et al. (2001) Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery 48:984–995PubMedCrossRef Jahan R, Murayama Y, Gobin YP et al. (2001) Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery 48:984–995PubMedCrossRef
8.
Zurück zum Zitat n-BCA Trail Investigators (2002) n-butyl cyanoacrylate embolization of cerebral arteriovenous malformations: results of a prospective, randomized, multi-center trial. AJNR Am J Neuroradiol 23:748–755 n-BCA Trail Investigators (2002) n-butyl cyanoacrylate embolization of cerebral arteriovenous malformations: results of a prospective, randomized, multi-center trial. AJNR Am J Neuroradiol 23:748–755
9.
Zurück zum Zitat Taylor CL, Dutton K, Rappard G et al. (2004) Complications of preoperative embolization of cerebral arteriovenous malformations. J Neurosurg 100:810–812PubMed Taylor CL, Dutton K, Rappard G et al. (2004) Complications of preoperative embolization of cerebral arteriovenous malformations. J Neurosurg 100:810–812PubMed
10.
Zurück zum Zitat Weber W, Kis B, Siekman R, Kuehne D (2007) Endovascular treatment of intracranial arteriovenous malformations with Onyx: Technical aspects. AJNR Am J Neuroradiol 28:371–377PubMed Weber W, Kis B, Siekman R, Kuehne D (2007) Endovascular treatment of intracranial arteriovenous malformations with Onyx: Technical aspects. AJNR Am J Neuroradiol 28:371–377PubMed
11.
Zurück zum Zitat van Rooij WJ, Sluzewski M, Beute GN (2007) Brain AVM Embolization with Onyx. AJNR Am J Neuroradiol 28:172–177PubMed van Rooij WJ, Sluzewski M, Beute GN (2007) Brain AVM Embolization with Onyx. AJNR Am J Neuroradiol 28:172–177PubMed
12.
Zurück zum Zitat Mounayer C, Hammami N, Piotin M et al. (2007) Nidal embolization of brain arteriovenous malformations using Onyx in 94 patients. AJNR Am J Neuroradiol 28:518–523PubMed Mounayer C, Hammami N, Piotin M et al. (2007) Nidal embolization of brain arteriovenous malformations using Onyx in 94 patients. AJNR Am J Neuroradiol 28:518–523PubMed
13.
Zurück zum Zitat Chyatte D (1997) Normal pressure perfusion breakthrough after resection of arteriovenous malformation. J Stroke Cerebrovasc Dis 6:130–136PubMedCrossRef Chyatte D (1997) Normal pressure perfusion breakthrough after resection of arteriovenous malformation. J Stroke Cerebrovasc Dis 6:130–136PubMedCrossRef
14.
Zurück zum Zitat Kato Y, Sano H, Nonomura K et al. (1997) Normal perfusion pressure breakthrough syndrome in giant arteriovenous malformations. Neurol Res 19:117–123PubMed Kato Y, Sano H, Nonomura K et al. (1997) Normal perfusion pressure breakthrough syndrome in giant arteriovenous malformations. Neurol Res 19:117–123PubMed
15.
Zurück zum Zitat Day AL, Friedman WA, Sypert GW, Mickle JP (1982) Successful treatment of the normal perfusion pressure breakthrough syndrome. Neurosurgery 11:625–630PubMedCrossRef Day AL, Friedman WA, Sypert GW, Mickle JP (1982) Successful treatment of the normal perfusion pressure breakthrough syndrome. Neurosurgery 11:625–630PubMedCrossRef
16.
Zurück zum Zitat Debrun GM, Aletich V, Ausman JI et al. (1997) Embolization of the nidus of brain arteriovenous malformations with n-butyl cyanoacrylate. Neurosurgery 40:112–120PubMedCrossRef Debrun GM, Aletich V, Ausman JI et al. (1997) Embolization of the nidus of brain arteriovenous malformations with n-butyl cyanoacrylate. Neurosurgery 40:112–120PubMedCrossRef
17.
Zurück zum Zitat Fournier D, TerBrugge KG, Willinsky R et al. (1991) Endovascular treatment of intracerebral arteriovenous malformations: experience in 49 cases. J Neurosurg 75:228–233PubMedCrossRef Fournier D, TerBrugge KG, Willinsky R et al. (1991) Endovascular treatment of intracerebral arteriovenous malformations: experience in 49 cases. J Neurosurg 75:228–233PubMedCrossRef
18.
Zurück zum Zitat Deruty R, Pelissou-Guyotat I, Mottolese C et al. (1993) The combined management of cerebral arteriovenous malformations. Experience with 100 cases and review of the literature. Acta Neurochir (Vienna) 123:101–112CrossRef Deruty R, Pelissou-Guyotat I, Mottolese C et al. (1993) The combined management of cerebral arteriovenous malformations. Experience with 100 cases and review of the literature. Acta Neurochir (Vienna) 123:101–112CrossRef
19.
Zurück zum Zitat Wilms G, Goffin J, Plets C et al (1993) Embolization of arteriovenous malformations of the brain: preliminary experience. J Belge Radiol 76:299–303PubMed Wilms G, Goffin J, Plets C et al (1993) Embolization of arteriovenous malformations of the brain: preliminary experience. J Belge Radiol 76:299–303PubMed
20.
Zurück zum Zitat Liu HM, Huang YC, Wang YH (2000) Embolization of cerebral arteriovenous malformations with n-butyl-cyanoacrylate. J Formos Med Assoc 99:906–913PubMed Liu HM, Huang YC, Wang YH (2000) Embolization of cerebral arteriovenous malformations with n-butyl-cyanoacrylate. J Formos Med Assoc 99:906–913PubMed
21.
Zurück zum Zitat Meisel HJ, Mansmann U, Alvarez H et al. (2002) Effect of partial targeted N-butyl-cyano-acrylate embolization in brain AVM. Acta Neurochir (Vienna) 144:879–887CrossRef Meisel HJ, Mansmann U, Alvarez H et al. (2002) Effect of partial targeted N-butyl-cyano-acrylate embolization in brain AVM. Acta Neurochir (Vienna) 144:879–887CrossRef
22.
Zurück zum Zitat Wikholm G, Lundquist C, Svendsen P (2001) The Goteborg cohort of embolized cerebral arteriovenous malformations: a 6-year follow-up. Neurosurgery 49:799–805PubMedCrossRef Wikholm G, Lundquist C, Svendsen P (2001) The Goteborg cohort of embolized cerebral arteriovenous malformations: a 6-year follow-up. Neurosurgery 49:799–805PubMedCrossRef
23.
Zurück zum Zitat Cronquist M, Wirestam R, Ramgren B et al. (2006) Endovascular treatment of intracerebral arteriovenous malformations: procedural safety, complications and results evaluated by MR imaging, including diffusion and perfusion imaging. AJNR Am J Neuroradiol 27:162–176 Cronquist M, Wirestam R, Ramgren B et al. (2006) Endovascular treatment of intracerebral arteriovenous malformations: procedural safety, complications and results evaluated by MR imaging, including diffusion and perfusion imaging. AJNR Am J Neuroradiol 27:162–176
24.
Zurück zum Zitat Haw CS, terBrugge K, Wllinsky R, Tomlinson G (2006) Complications of embolization of arteriovenous malformations of the brain. J Neurosurg 104:226–232PubMedCrossRef Haw CS, terBrugge K, Wllinsky R, Tomlinson G (2006) Complications of embolization of arteriovenous malformations of the brain. J Neurosurg 104:226–232PubMedCrossRef
25.
Zurück zum Zitat DeMeritt JS, Pile-Spellman J, Mast H (1995) Outcome analysis of preoperative embolization with n-butyl cyanoacrylate in cerebral arteriovenous malformations. AJNR Am J Neuroradiol 16:1801–1807PubMed DeMeritt JS, Pile-Spellman J, Mast H (1995) Outcome analysis of preoperative embolization with n-butyl cyanoacrylate in cerebral arteriovenous malformations. AJNR Am J Neuroradiol 16:1801–1807PubMed
26.
Zurück zum Zitat Frizzel RT, Fisher WS 3rd (1995) Cure, morbidity and mortality associated with embolization of brain arteriovenous malformations: a review of 1246 patients in 32 series over a 35-year period. Neurosurgery 37:1039–1040CrossRef Frizzel RT, Fisher WS 3rd (1995) Cure, morbidity and mortality associated with embolization of brain arteriovenous malformations: a review of 1246 patients in 32 series over a 35-year period. Neurosurgery 37:1039–1040CrossRef
27.
Zurück zum Zitat Valavanis A, Yasargil MG (1998) The endovascular treatment of brain arteriovenous malformations. Adv Tech Stand Neurosurg 24:131–140PubMed Valavanis A, Yasargil MG (1998) The endovascular treatment of brain arteriovenous malformations. Adv Tech Stand Neurosurg 24:131–140PubMed
Metadaten
Titel
Curative embolization of cerebral arteriovenous malformations (AVMs) with Onyx in 101 patients
verfasst von
Vasilios Katsaridis
Chrysanthi Papagiannaki
Enrico Aimar
Publikationsdatum
01.07.2008
Verlag
Springer-Verlag
Erschienen in
Neuroradiology / Ausgabe 7/2008
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-008-0382-x

Weitere Artikel der Ausgabe 7/2008

Neuroradiology 7/2008 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.