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Erschienen in:

01.05.2012 | Paediatric Neuroradiology

Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development

verfasst von: Elise Roze, Polly A. Harris, Gareth Ball, Leire Zubiaurre Elorza, Rodrigo M. Braga, Joanna M. Allsop, Nazakat Merchant, Emma Porter, Tomoki Arichi, A. David Edwards, Mary A. Rutherford, Frances M. Cowan, Serena J. Counsell

Erschienen in: Neuroradiology | Ausgabe 5/2012

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Abstract

Introduction

Our aims were to (1) assess the corticospinal tracts (CSTs) in infants with focal injury and healthy term controls using probabilistic tractography and (2) to correlate the conventional magnetic resonance imaging (MRI) and tractography findings in infants with focal injury with their later motor function.

Methods

We studied 20 infants with focal lesions and 23 controls using MRI and diffusion tensor imaging. Tract volume, fractional anisotropy (FA), apparent diffusion coefficient (ADC) values, axial diffusivity and radial diffusivity (RD) of the CSTs were determined. Asymmetry indices (AIs) were calculated by comparing ipsilateral to contralateral CSTs. Motor outcome was assessed using a standardized neurological examination.

Results

Conventional MRI was able to predict normal motor development (n = 9) or hemiplegia (n = 6). In children who developed a mild motor asymmetry (n = 5), conventional MRI predicted a hemiplegia in two and normal motor development in three infants. The AIs for tract volume, FA, ADC and RD showed a significant difference between controls and infants who developed a hemiplegia, and RD also showed a significant difference in AI between controls and infants who developed a mild asymmetry.

Conclusion

Conventional MRI was able to predict subsequent normal motor development or hemiplegia following focal injury in newborn infants. Measures of RD obtained from diffusion tractography may offer additional information for predicting a subsequent asymmetry in motor function.

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Titel: Tractography of the corticospinal tracts in infants with focal perinatal injury: comparison with normal controls and to motor development
verfasst von: Elise Roze
Polly A. Harris
Gareth Ball
Leire Zubiaurre Elorza
Rodrigo M. Braga
Joanna M. Allsop
Nazakat Merchant
Emma Porter
Tomoki Arichi
A. David Edwards
Mary A. Rutherford
Frances M. Cowan
Serena J. Counsell
Publikationsdatum: 01.05.2012
Verlag: Springer-Verlag
Erschienen in: Neuroradiology / Ausgabe 5/2012
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-011-0969-5

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Abstract

Introduction

Methods

Results

Conclusion

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