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01.07.2015 | Original Article

Corpus callosum thickness on mid-sagittal MRI as a marker of brain volume: a pilot study in children with HIV-related brain disease and controls

verfasst von: Savvas Andronikou, Christelle Ackermann, Barbara Laughton, Mark Cotton, Nicollette Tomazos, Bruce Spottiswoode, Katya Mauff, John M. Pettifor

Erschienen in: Pediatric Radiology | Ausgabe 7/2015

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Abstract

Background

Corpus callosum thickness measurement on mid-sagittal MRI may be a surrogate marker of brain volume. This is important for evaluation of diseases causing brain volume gain or loss, such as HIV-related brain disease and HIV encephalopathy.

Objective

To determine if thickness of the corpus callosum on mid-sagittal MRI is a surrogate marker of brain volume in children with HIV-related brain disease and in controls without HIV.

Materials and methods

A retrospective MRI analysis in children (<5 years old) with HIV-related brain disease and controls used a custom-developed semi-automated tool, which divided the midline corpus callosum and measured its thickness in multiple locations. Brain volume was determined using volumetric analysis. Overall corpus callosum thickness and thickness of segments of the corpus callosum were correlated with overall and segmented (grey and white matter) brain volume.

Results

Forty-four children (33 HIV-infected patients and 11 controls) were included. Significant correlations included overall corpus callosum (mean) and total brain volume (P = 0.05); prefrontal corpus callosum maximum with white matter volume (P = 0.02); premotor corpus callosum mean with total brain volume (P = 0.04) and white matter volume (P = 0.02), premotor corpus callosum maximum with white matter volume (P = 0.02) and sensory corpus callosum mean with total brain volume (P = 0.02).

Conclusion

Corpus callosum thickness correlates with brain volume both in HIV-infected patients and controls.

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Titel: Corpus callosum thickness on mid-sagittal MRI as a marker of brain volume: a pilot study in children with HIV-related brain disease and controls
verfasst von: Savvas Andronikou
Christelle Ackermann
Barbara Laughton
Mark Cotton
Nicollette Tomazos
Bruce Spottiswoode
Katya Mauff
John M. Pettifor
Publikationsdatum: 01.07.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 7/2015
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-014-3255-y

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Corpus callosum thickness on mid-sagittal MRI as a marker of brain volume: a pilot study in children with HIV-related brain disease and controls

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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Abstract

Background

Objective

Materials and methods

Results

Conclusion

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