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Cancer Immunology, Immunotherapy

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01.09.2008 | Review

Toll-like receptors expressed in tumor cells: targets for therapy

verfasst von: Li Yu, Shangwu Chen

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 9/2008

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Abstract

Toll-like receptors (TLRs), mainly expressing in human immune related cells and epithelial cells, play an essential role in the host defense against microbes by recognizing conserved bacterial molecules. Recently, the expression or up-regulation of TLRs has been detected in many tumor cell lines or tumors, especially epithelial derived cancers. Although the TLR profile varies on different tumor cells, the current evidences indicate that the expression of TLRs is functionally associated with tumor progression. TLR expression may promote malignant transformation of epithelial cells. Engagement of TLRs increases tumor growth and tumor immune escape, and induces apoptosis resistance and chemoresistance in some tumor cells. These findings demonstrate that TLR is a promising target for the development of anticancer drugs and make TLR agonists or antagonists the potential agents for tumor therapy.

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Titel: Toll-like receptors expressed in tumor cells: targets for therapy
verfasst von: Li Yu
Shangwu Chen
Publikationsdatum: 01.09.2008
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 9/2008
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-008-0459-8

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Toll-like receptors expressed in tumor cells: targets for therapy

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