Skip to main content
Erschienen in: Aesthetic Plastic Surgery 5/2013

01.10.2013 | Review

Understanding the Functional Anatomy of the Frontalis and Glabellar Complex for Optimal Aesthetic Botulinum Toxin Type A Therapy

verfasst von: Z. Paul Lorenc, Stacy Smith, Mark Nestor, Diane Nelson, Amir Moradi

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 5/2013

Einloggen, um Zugang zu erhalten

Abstract

Background

Botulinum neurotoxin type A (BoNTA) is approved for the treatment of glabellar lines and also is commonly injected in an off-label fashion in the frontalis (i.e., frontalis epicranius) muscle to improve the appearance of horizontal forehead lines. This study aimed to review and discuss both the anatomy and physiology of the frontalis muscle and its relationship with antagonist muscles in the upper face and to provide a guide for the use of BoNTA to treat forehead rhytides while minimizing the occurrence of complications such as brow ptosis.

Methods

A PubMed search was conducted to identify practitioner opinion and clinical publications on the efficacy and safety of BoNTA for aesthetic treatment of the upper face.

Results

The use of BoNTA produces durable improvement in the appearance of moderate to severe horizontal forehead lines. Dose and injection technique must be adjusted and individualized based on the variable anatomy and function/mass of muscles in the forehead and upper face as well as on patient goals. Optimal aesthetic outcomes can be achieved by skillfully balancing the opposing effects of the frontalis muscle and its intricate interactions with the procerus, corrugator supercilii, depressor supercilii, and orbicularis oculi muscles.

Conclusions

The use of BoNTA to improve the aesthetic appearance of horizontal forehead lines is optimized when clinicians take into account variations in frontalis muscle function and position, anatomy of the brow, and proper injection technique when they devise individualized treatment regimens.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literatur
1.
Zurück zum Zitat Botox Cosmetic (2010) (onabotulinumtoxinA): full prescribing information. Allergan Inc., Irvine Botox Cosmetic (2010) (onabotulinumtoxinA): full prescribing information. Allergan Inc., Irvine
2.
Zurück zum Zitat Dysport (2010) (abobotulinumtoxinA): full prescribing information. Medicis Aesthetics Inc., Scottsdale Dysport (2010) (abobotulinumtoxinA): full prescribing information. Medicis Aesthetics Inc., Scottsdale
3.
Zurück zum Zitat Xeomin (2011) (incobotulinumtoxinA): full prescribing information. Merz Pharmaceuticals, LLC, Greensboro Xeomin (2011) (incobotulinumtoxinA): full prescribing information. Merz Pharmaceuticals, LLC, Greensboro
4.
Zurück zum Zitat Ascher B, Talarico S, Cassuto D, Escobar S, Hexsel D, Jaen P, Monheit GD, Rzany B, Viel M (2010) International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit): Part I. Upper facial wrinkles. J Eur Acad Dermatol Venereol 24:1278–1284PubMedCrossRef Ascher B, Talarico S, Cassuto D, Escobar S, Hexsel D, Jaen P, Monheit GD, Rzany B, Viel M (2010) International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit): Part I. Upper facial wrinkles. J Eur Acad Dermatol Venereol 24:1278–1284PubMedCrossRef
5.
Zurück zum Zitat Carruthers JD, Glogau RG, Blitzer A (2008) Advances in facial rejuvenation: Botulinum toxin type A, hyaluronic acid dermal fillers, and combination therapies: consensus recommendations. Plast Reconstr Surg 121(5):5S–30S quiz 31S–36SPubMed Carruthers JD, Glogau RG, Blitzer A (2008) Advances in facial rejuvenation: Botulinum toxin type A, hyaluronic acid dermal fillers, and combination therapies: consensus recommendations. Plast Reconstr Surg 121(5):5S–30S quiz 31S–36SPubMed
6.
Zurück zum Zitat Kane M, Donofrio L, Ascher B, Hexsel D, Monheit G, Rzany B, Weiss R (2010) Expanding the use of neurotoxins in facial aesthetics: a consensus panel’s assessment and recommendations. J Drugs Dermatol 9(1):s7–s22 quiz s23–s25PubMed Kane M, Donofrio L, Ascher B, Hexsel D, Monheit G, Rzany B, Weiss R (2010) Expanding the use of neurotoxins in facial aesthetics: a consensus panel’s assessment and recommendations. J Drugs Dermatol 9(1):s7–s22 quiz s23–s25PubMed
7.
Zurück zum Zitat Carruthers A, Carruthers J, Cohen J (2003) A prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in female subjects with horizontal forehead rhytides. Dermatol Surg 29:461–467PubMedCrossRef Carruthers A, Carruthers J, Cohen J (2003) A prospective, double-blind, randomized, parallel-group, dose-ranging study of botulinum toxin type A in female subjects with horizontal forehead rhytides. Dermatol Surg 29:461–467PubMedCrossRef
8.
Zurück zum Zitat Carruthers J, Fagien S, Matarasso SL (2004) Consensus recommendations on the use of botulinum toxin type A in facial aesthetics. Plast Reconstr Surg 114(6):1S–22SPubMed Carruthers J, Fagien S, Matarasso SL (2004) Consensus recommendations on the use of botulinum toxin type A in facial aesthetics. Plast Reconstr Surg 114(6):1S–22SPubMed
9.
Zurück zum Zitat Nestor MS, Ablon GR (2011) Duration of action of abobotulinumtoxinA and onabotulinumtoxinA: a randomized, double-blind study using a contralateral frontalis model. J Clin Aesthet Dermatol 4:43–49PubMed Nestor MS, Ablon GR (2011) Duration of action of abobotulinumtoxinA and onabotulinumtoxinA: a randomized, double-blind study using a contralateral frontalis model. J Clin Aesthet Dermatol 4:43–49PubMed
10.
Zurück zum Zitat Benedetto AV (ed) (2006) Botulinum toxin in clinical dermatology. Taylor and Francis, Milton Park Benedetto AV (ed) (2006) Botulinum toxin in clinical dermatology. Taylor and Francis, Milton Park
11.
Zurück zum Zitat Macdonald MR, Spiegel JH, Raven RB, Kabaker SS, Maas CS (1998) An anatomical approach to glabellar rhytids. Arch Otolaryngol Head Neck Surg 124:1315–1320PubMedCrossRef Macdonald MR, Spiegel JH, Raven RB, Kabaker SS, Maas CS (1998) An anatomical approach to glabellar rhytids. Arch Otolaryngol Head Neck Surg 124:1315–1320PubMedCrossRef
12.
Zurück zum Zitat Benedetto AV, Lahti JG (2005) Measurement of the anatomic position of the corrugator supercilii. Dermatol Surg 31(8 Pt 1):923–927PubMed Benedetto AV, Lahti JG (2005) Measurement of the anatomic position of the corrugator supercilii. Dermatol Surg 31(8 Pt 1):923–927PubMed
13.
Zurück zum Zitat Cook BE Jr, Lucarelli MJ, Lemke BN (2001) Depressor supercilii muscle: anatomy, histology, and cosmetic implications. Ophthal Plast Reconstr Surg 17:404–411PubMedCrossRef Cook BE Jr, Lucarelli MJ, Lemke BN (2001) Depressor supercilii muscle: anatomy, histology, and cosmetic implications. Ophthal Plast Reconstr Surg 17:404–411PubMedCrossRef
14.
Zurück zum Zitat Clauser L, Tieghi R, Galie M (2006) Palpebral ptosis: clinical classification, differential diagnosis, and surgical guidelines: an overview. J Craniofac Surg 17:246–254PubMedCrossRef Clauser L, Tieghi R, Galie M (2006) Palpebral ptosis: clinical classification, differential diagnosis, and surgical guidelines: an overview. J Craniofac Surg 17:246–254PubMedCrossRef
15.
Zurück zum Zitat Troilius C (2004) Subperiosteal brow lifts without fixation. Plast Reconstr Surg 114:1595–1603 discussion 1604–1605PubMed Troilius C (2004) Subperiosteal brow lifts without fixation. Plast Reconstr Surg 114:1595–1603 discussion 1604–1605PubMed
16.
Zurück zum Zitat Ezure T, Amano S (2010) The severity of wrinkling at the forehead is related to the degree of ptosis of the upper eyelid. Skin Res Technol 16:202–209PubMedCrossRef Ezure T, Amano S (2010) The severity of wrinkling at the forehead is related to the degree of ptosis of the upper eyelid. Skin Res Technol 16:202–209PubMedCrossRef
17.
Zurück zum Zitat Finsterer J (2003) Ptosis: causes, presentation, and management. Aesthetic Plast Surg 27:193–204PubMedCrossRef Finsterer J (2003) Ptosis: causes, presentation, and management. Aesthetic Plast Surg 27:193–204PubMedCrossRef
19.
Zurück zum Zitat Bartley GB, Lowry JC, Hodge DO (1996) Results of levator-advancement blepharoptosis repair using a standard protocol: effect of epinephrine-induced eyelid position change. Trans Am Ophthalmol Soc 94:165–173 discussion 174–177PubMed Bartley GB, Lowry JC, Hodge DO (1996) Results of levator-advancement blepharoptosis repair using a standard protocol: effect of epinephrine-induced eyelid position change. Trans Am Ophthalmol Soc 94:165–173 discussion 174–177PubMed
20.
Zurück zum Zitat Lowe NJ, Shah A, Lowe PL, Patnaik R (2010) Dosing, efficacy, and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines. J Cosmet Laser Ther 12:106–111PubMedCrossRef Lowe NJ, Shah A, Lowe PL, Patnaik R (2010) Dosing, efficacy, and safety plus the use of computerized photography for botulinum toxins type A for upper facial lines. J Cosmet Laser Ther 12:106–111PubMedCrossRef
21.
Zurück zum Zitat Hexsel D, Spencer JM, Woolery-Lloyd H, Gilbert E (2010) Practical applications of a new botulinum toxin. J Drugs Dermatol 9(3):s31–s37PubMed Hexsel D, Spencer JM, Woolery-Lloyd H, Gilbert E (2010) Practical applications of a new botulinum toxin. J Drugs Dermatol 9(3):s31–s37PubMed
22.
Zurück zum Zitat Carruthers A, Carruthers J (2009) A single-center dose-comparison study of botulinum neurotoxin type A in females with upper facial rhytids: assessing patients’ perception of treatment outcomes. J Drugs Dermatol 8:924–929PubMed Carruthers A, Carruthers J (2009) A single-center dose-comparison study of botulinum neurotoxin type A in females with upper facial rhytids: assessing patients’ perception of treatment outcomes. J Drugs Dermatol 8:924–929PubMed
23.
Zurück zum Zitat Carruthers A, Carruthers J (2009) A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: safety and efficacy. J Am Acad Dermatol 60:972–979PubMedCrossRef Carruthers A, Carruthers J (2009) A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: safety and efficacy. J Am Acad Dermatol 60:972–979PubMedCrossRef
24.
Zurück zum Zitat Karsai S, Adrian R, Hammes S, Thimm J, Raulin C (2007) A randomized double-blind study of the effect of Botox and Dysport/Reloxin on forehead wrinkles and electromyographic activity. Arch Dermatol 143:1447–1449PubMedCrossRef Karsai S, Adrian R, Hammes S, Thimm J, Raulin C (2007) A randomized double-blind study of the effect of Botox and Dysport/Reloxin on forehead wrinkles and electromyographic activity. Arch Dermatol 143:1447–1449PubMedCrossRef
25.
Zurück zum Zitat Nestor MS, Ablon GR (2011) Comparing the clinical attributes of abobotulinumtoxinA and onabotulinumtoxinA utilizing a novel contralateral frontalis model and the Frontalis Activity Measurement Standard. J Drugs Dermatol 10:1148–1157PubMed Nestor MS, Ablon GR (2011) Comparing the clinical attributes of abobotulinumtoxinA and onabotulinumtoxinA utilizing a novel contralateral frontalis model and the Frontalis Activity Measurement Standard. J Drugs Dermatol 10:1148–1157PubMed
26.
Zurück zum Zitat Nestor MS, Ablon GR (2011) The Frontalis Activity Measurement Standard: a novel contralateral method for assessing botulinum neurotoxin type-A activity. J Drugs Dermatol 10:968–972PubMed Nestor MS, Ablon GR (2011) The Frontalis Activity Measurement Standard: a novel contralateral method for assessing botulinum neurotoxin type-A activity. J Drugs Dermatol 10:968–972PubMed
27.
Zurück zum Zitat Binder WJ (2006) Long-term effects of botulinum toxin type A (Botox) on facial lines: a comparison in identical twins. Arch Facial Plast Surg 8:426–431PubMedCrossRef Binder WJ (2006) Long-term effects of botulinum toxin type A (Botox) on facial lines: a comparison in identical twins. Arch Facial Plast Surg 8:426–431PubMedCrossRef
28.
Zurück zum Zitat de Boulle K (2008) Patient satisfaction with different botulinum toxin type A formulations in the treatment of moderate to severe upper facial rhytids. J Cosmet Laser Ther 10:87–92PubMedCrossRef de Boulle K (2008) Patient satisfaction with different botulinum toxin type A formulations in the treatment of moderate to severe upper facial rhytids. J Cosmet Laser Ther 10:87–92PubMedCrossRef
29.
Zurück zum Zitat Ghalamkarpour F, Robati RM, Aryanejad F, Toossi P (2010) Supraciliary wrinkles and botulinum toxin A. Clin Exp Dermatol 35:388–391PubMedCrossRef Ghalamkarpour F, Robati RM, Aryanejad F, Toossi P (2010) Supraciliary wrinkles and botulinum toxin A. Clin Exp Dermatol 35:388–391PubMedCrossRef
30.
Zurück zum Zitat Hevia O (2010) Retrospective review of 500 patients treated with abobotulinumtoxinA. J Drugs Dermatol 9:1081–1084PubMed Hevia O (2010) Retrospective review of 500 patients treated with abobotulinumtoxinA. J Drugs Dermatol 9:1081–1084PubMed
31.
Zurück zum Zitat Hsu TS, Dover JS, Arndt KA (2004) Effect of volume and concentration on the diffusion of botulinum exotoxin A. Arch Dermatol 140:1351–1354PubMedCrossRef Hsu TS, Dover JS, Arndt KA (2004) Effect of volume and concentration on the diffusion of botulinum exotoxin A. Arch Dermatol 140:1351–1354PubMedCrossRef
32.
Zurück zum Zitat Levy JL, Pons F, Jouve E (2006) Management of the ageing eyebrow and forehead: an objective dose-response study with botulinum toxin. J Eur Acad Dermatol Venereol 20:711–716PubMedCrossRef Levy JL, Pons F, Jouve E (2006) Management of the ageing eyebrow and forehead: an objective dose-response study with botulinum toxin. J Eur Acad Dermatol Venereol 20:711–716PubMedCrossRef
33.
Zurück zum Zitat Manstein CH, Beidas OE (2011) Comparing clinical efficacy of Botox and Dysport in a small group of patients. Plast Reconstr Surg 128:26e–27ePubMedCrossRef Manstein CH, Beidas OE (2011) Comparing clinical efficacy of Botox and Dysport in a small group of patients. Plast Reconstr Surg 128:26e–27ePubMedCrossRef
34.
Zurück zum Zitat Cliff SH, Judodihardjo H, Eltringham E (2008) Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study. J Cosmet Dermatol 7:50–54PubMedCrossRef Cliff SH, Judodihardjo H, Eltringham E (2008) Different formulations of botulinum toxin type A have different migration characteristics: a double-blind, randomized study. J Cosmet Dermatol 7:50–54PubMedCrossRef
36.
Zurück zum Zitat Michaels BM, Csank GA, Ryb GE, Eko FN, Rubin A (2012) Prospective randomized comparison of onabotulinumtoxinA (Botox) and abobotulinumtoxinA (Dysport) in the treatment of forehead, glabellar, and periorbital wrinkles. Aesthet Surg J 32:96–102PubMedCrossRef Michaels BM, Csank GA, Ryb GE, Eko FN, Rubin A (2012) Prospective randomized comparison of onabotulinumtoxinA (Botox) and abobotulinumtoxinA (Dysport) in the treatment of forehead, glabellar, and periorbital wrinkles. Aesthet Surg J 32:96–102PubMedCrossRef
37.
Zurück zum Zitat Oliveira de Morais O, Matos Reis-Filho E, Vilela Pereira L, Martins Gomes C, Alves G (2012) Comparison of four botulinum neurotoxin type A preparations in the treatment of hyperdynamic forehead lines in men: a pilot study. J Drugs Dermatol 11:216–219 Oliveira de Morais O, Matos Reis-Filho E, Vilela Pereira L, Martins Gomes C, Alves G (2012) Comparison of four botulinum neurotoxin type A preparations in the treatment of hyperdynamic forehead lines in men: a pilot study. J Drugs Dermatol 11:216–219
38.
Zurück zum Zitat Grimes PE, Shabazz D (2009) A four-month randomized, double-blind evaluation of the efficacy of botulinum toxin type A for the treatment of glabellar lines in women with skin types V and VI. Dermatol Surg 35:429–435 discussion 435–436CrossRef Grimes PE, Shabazz D (2009) A four-month randomized, double-blind evaluation of the efficacy of botulinum toxin type A for the treatment of glabellar lines in women with skin types V and VI. Dermatol Surg 35:429–435 discussion 435–436CrossRef
39.
Zurück zum Zitat Taylor SC, Callender VD, Albright CD, Coleman J, Axford-Gatley RA, Lin X (2012) AbobotulinumtoxinA for reduction of glabellar lines in patients with skin of color: post hoc analysis of pooled clinical trial data. Dermatol Surg 38:1804–1811PubMedCrossRef Taylor SC, Callender VD, Albright CD, Coleman J, Axford-Gatley RA, Lin X (2012) AbobotulinumtoxinA for reduction of glabellar lines in patients with skin of color: post hoc analysis of pooled clinical trial data. Dermatol Surg 38:1804–1811PubMedCrossRef
40.
Zurück zum Zitat Levy LL, Emer JJ (2012) Complications of minimally invasive cosmetic procedures: prevention and management. J Cutan Aesthetic Surg 5:121–132CrossRef Levy LL, Emer JJ (2012) Complications of minimally invasive cosmetic procedures: prevention and management. J Cutan Aesthetic Surg 5:121–132CrossRef
41.
Zurück zum Zitat Maas C, Kane MA, Bucay VW, Allen S, Applebaum DJ, Baumann L, Cox SE, Few JW, Joseph JH, Lorenc ZP, Moradi A, Nestor MS, Schlessinger J, Wortzman M, Lawrence I, Lin X, Nelson D (2012) Current aesthetic use of abobotulinumtoxinA in clinical practice: an evidence-based consensus review. Aesthet Surg J 32(1):8S–29SPubMed Maas C, Kane MA, Bucay VW, Allen S, Applebaum DJ, Baumann L, Cox SE, Few JW, Joseph JH, Lorenc ZP, Moradi A, Nestor MS, Schlessinger J, Wortzman M, Lawrence I, Lin X, Nelson D (2012) Current aesthetic use of abobotulinumtoxinA in clinical practice: an evidence-based consensus review. Aesthet Surg J 32(1):8S–29SPubMed
42.
Zurück zum Zitat Monheit GD, Lin X, Nelson D, Kane MA (2012) Consideration of muscle mass in glabellar line treatment with botulinum toxin type A. J Drugs Dermatol 11:1041–1045PubMed Monheit GD, Lin X, Nelson D, Kane MA (2012) Consideration of muscle mass in glabellar line treatment with botulinum toxin type A. J Drugs Dermatol 11:1041–1045PubMed
Metadaten
Titel
Understanding the Functional Anatomy of the Frontalis and Glabellar Complex for Optimal Aesthetic Botulinum Toxin Type A Therapy
verfasst von
Z. Paul Lorenc
Stacy Smith
Mark Nestor
Diane Nelson
Amir Moradi
Publikationsdatum
01.10.2013
Verlag
Springer US
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 5/2013
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-013-0178-1

Weitere Artikel der Ausgabe 5/2013

Aesthetic Plastic Surgery 5/2013 Zur Ausgabe

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 Ablationstherapie Nachrichten

Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Ureterstriktur: Innovative OP-Technik bewährt sich

19.04.2024 EAU 2024 Kongressbericht

Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.