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01.08.2010 | Original Article

Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma

verfasst von: Zorica Cvetković, Vesna Vučić, Bora Cvetković, Milan Petrović, Danijela Ristić-Medić, Jasna Tepšić, Maria Glibetić

Erschienen in: Annals of Hematology | Ausgabe 8/2010

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Abstract

The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p < 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p < 0.01). The level of oleic acid in patients with indolent NHL was significantly lower (p < 0.05) than in more aggressive types of disease. Contents of palmitoleic acid, docosatetraenoic (22:4 n-6), and PUFA was lower in very aggressive NHL. According to clinical stage (CS), patients with CS I had significantly higher SFA and lower n-6 FA than other three groups, and group with CS IV showed significantly decreased DHA and n-3 PUFA. Our results showed an abnormal FA profile in serum phospholipids in NHL patients.

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Titel: Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma
verfasst von: Zorica Cvetković
Vesna Vučić
Bora Cvetković
Milan Petrović
Danijela Ristić-Medić
Jasna Tepšić
Maria Glibetić
Publikationsdatum: 01.08.2010
Verlag: Springer-Verlag
Erschienen in: Annals of Hematology / Ausgabe 8/2010
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-010-0904-6

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Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma

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