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01.04.2012 | Original Article

Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time

verfasst von: Edis Belini Junior, Danilo Grünig Humberto da Silva, Lidiane de Souza Torres, Eduardo Alves de Almeida, Rodolfo Delfini Cancado, Carlos Chiattone, Claudia Regina Bonini-Domingos

Erschienen in: Annals of Hematology | Ausgabe 4/2012

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Abstract

To evaluate, in a longitudinal study, the profile of lipid peroxidation and antioxidant capacity markers in sickle cell anaemia patients receiving different treatments and medication over different time periods. The three groups were: patients undergoing transfusion therapy and receiving iron chelator deferasirox (DFX group, n = 20); patients receiving deferasirox and hydroxyurea (DFX + HU group, n = 10), and patients receiving only folic acid (FA group, n = 15). Thiobarbituric acid-reactive substance (TBARS) assays and trolox-equivalent antioxidant capacity (TEAC) assays were evaluated during two different periods of analysis, T0 and T1 (after ~388 days). Higher FA group TBARS values were observed compared with the DFX + HU group (p = 0.016) at T0; and at T1, higher FA group TBARS values were also observed compared with both the DFX group (p = 0.003) and the DFX + HU group (p = 0.0002). No variation in TEAC values was seen between groups, at either T0 or T1. The mean values of TBARS and TEAC for both the DFX and DFX + HU groups decreased at T1. The antioxidant effects of HU and DFX were observed by through an increase in TEAC levels in DFX and DFX + HU groups when compared with those of normal subjects. Increased TEAC values were not recorded in the FA group, and lipid peroxidation was seen to decrease after DFX and HU use.

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Titel: Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time
verfasst von: Edis Belini Junior
Danilo Grünig Humberto da Silva
Lidiane de Souza Torres
Eduardo Alves de Almeida
Rodolfo Delfini Cancado
Carlos Chiattone
Claudia Regina Bonini-Domingos
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Annals of Hematology / Ausgabe 4/2012
Print ISSN: 0939-5555
Elektronische ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-011-1340-y

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Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time

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