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Seminars in Immunopathology

Erschienen in:

01.01.2005 | Original Paper

Dendritic cell-mediated T cell polarization

verfasst von: Esther C. de Jong, Hermelijn H. Smits, Martien L. Kapsenberg

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2005

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Abstract

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4⁺ T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.

Agata Y, Kawasaki A, Nishimura H, et al (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 8:765

Akiba H, Miyahira Y, Atsuta M, et al (2000) Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. J Exp Med 191:375

Asselin-Paturel C, Boonstra A, Dalod M, et al (2001) Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2:1144

Athie-Morales V, Smits HH, Cantrell DA, et al (2004) Sustained IL-12 signaling is required for Th1 development. J Immunol 172:61

Bach JF (2003) Regulatory T cells under scrutiny. Nat Rev Immunol 3:189

Banchereau J, Briere F, Caux C, et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767

Barbulescu K, Becker C, Schlaak JF, et al (1998) IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4⁺ T lymphocytes. J Immunol 160:3642

Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3:253

Boring L, Gosling J, Chensue SW, et al (1997) Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest 100:2552

10.

Carr JA, Rogerson JA, Mulqueen MJ, et al (1999) The role of endogenous interleukin-12 in resistance to murine cytomegalovirus (MCMV) infection and a novel action for endogenous IL-12 p40. J Interferon Cytokine Res 19:1145

11.

Cavani A, Nasorri F, Prezzi C, et al (2000) Human CD4⁺ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses. J Invest Dermatol 114:295

12.

Cella M, Dohring C, Samaridis J, et al (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med 185:1743

13.

Chang CC, Ciubotariu R, Manavalan JS, et al (2002) Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 3:237

14.

Chapoval AI, Ni J, Lau JS, et al (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2:269

15.

Chen AI, McAdam AJ, Buhlmann JE, et al (1999) Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity 11:689

16.

Chen Q, Ghilardi N, Wang H, et al (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407:916

17.

Chensue SW, Warmington KS, Ruth JH, et al (1996) Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production. J Immunol 157:4602

18.

Colonna M, Nakajima H, Navarro F, et al (1999) A novel family of Ig-like receptors for HLA class I molecules that modulate function of lymphoid and myeloid cells. J Leukoc Biol 66:375

19.

Colonna M, Samaridis J, Cella M, et al (1998) Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol 160:3096

20.

Croft M (2003) Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat Rev Immunol 3:609

21.

Cua DJ, Sherlock J, Chen Y, et al (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744

22.

Daly C, Rollins BJ (2003) Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies. Microcirculation 10:247

23.

De Jong EC, Vieira PL, Kalinski P, et al (1999) Corticosteroids inhibit the production of inflammatory mediators in immature monocyte-derived DC and induce the development of tolerogenic DC3. J Leukoc Biol 66:201

24.

De Jong EC, Vieira PL, Kalinski P, et al (2002) Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J Immunol 168:1704

25.

De Maeyer E, Maeyer-Guignard J (1998) Type I interferons. Int Rev Immunol 17:53

26.

De Waal MR, Haanen J, Spits H, et al (1991) Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 174:915

27.

Devergne O, Hummel M, Koeppen H, et al (1996) A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 70:1143

28.

Diebold SS, Kaisho T, Hemmi H, et al (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529

29.

Dong H, Zhu G, Tamada K, et al (1999) B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 5:1365

30.

Dong H, Zhu G, Tamada K, et al (2004) B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20:327

31.

d’Ostiani CF, Del Sero G, Bacci A, et al (2000) Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J Exp Med 191:1661

32.

Dunne A, Ejdeback M, Ludidi PL, et al (2003) Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem 278:41443

33.

Edwards AD, Manickasingham SP, Sporri R, et al (2002) Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol 169:3652

34.

Fieschi C, Dupuis S, Catherinot E, et al (2003) Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J Exp Med 197:527

35.

Flynn S, Toellner KM, Raykundalia C, et al (1998) CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med 188:297

36.

Freeman GJ, Long AJ, Iwai Y, et al (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192:1027

37.

Fukaura H, Kent SC, Pietrusewicz MJ, et al (1996) Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 98:70

38.

Gately MK, Renzetti LM, Magram J, et al (1998) The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 16:495

39.

Giacomini E, Iona E, Ferroni L, et al (2001) Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response. J Immunol 166:7033

40.

Gonzalo JA, Lloyd CM, Wen D, et al (1998) The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 188:157

41.

Gregori S, Casorati M, Amuchastegui S, et al (2001) Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167:1945

42.

Groux H, O’Garra A, Bigler M, et al (1997) A CD4⁺ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737

43.

Hamano S, Himeno K, Miyazaki Y, et al (2003) WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19:657

44.

Heil F, Hemmi H, Hochrein H, et al (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526

45.

Henri S, Vremec D, Kamath A, et al (2001) The dendritic cell populations of mouse lymph nodes. J Immunol 167:741

46.

Hochrein H, O’Keeffe M, Luft T, et al (2000) Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med 192:823

47.

Hoyne GF, Le R, I, Corsin-Jimenez M, et al (2000) Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int Immunol 12:177

48.

Inobe J, Slavin AJ, Komagata Y, et al (1998) IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol 28:2780

49.

Ishida Y, Agata Y, Shibahara K, et al (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11:3887

50.

Janeway CA Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197

51.

Jankovic D, Kullberg MC, Noben-Trauth N, et al (2000) Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4⁺ lymphocytes with a Th2 cytokine profile. J Immunol 164:3047

52.

Jarrossay D, Napolitani G, Colonna M, et al (2001) Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 31:3388

53.

Jonuleit H, Schmitt E, Schuler G, et al (2000) Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192:1213

54.

Joss A, Akdis M, Faith A, et al (2000) IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway. Eur J Immunol 30:1683

55.

Kadowaki N, Antonenko S, Lau JY, et al (2000) Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med 192:219

56.

Kadowaki N, Ho S, Antonenko S, et al (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194:863

57.

Kaisho T, Akira S (2003) Regulation of dendritic cell function through toll-like receptors. Curr Mol Med 3:759

58.

Kalinski P, Hilkens CM, Wierenga EA, et al (1999) T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 20:561

59.

Kalinski P, Schuitemaker JH, Hilkens CM, et al (1999) Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J Immunol 162:3231

60.

Kalinski P, Smits HH, Schuitemaker JH, et al (2000) IL-4 is a mediator of IL-12p70 induction by human Th2 cells: reversal of polarized Th2 phenotype by dendritic cells. J Immunol 165:1877

61.

Kaplan MH, Sun YL, Hoey T, et al (1996) Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174

62.

Kapsenberg ML (2003) Dendritic-cell control of pathogen-driven T-cell polarization. Nat Rev Immunol 3:984

63.

Karpus WJ, Kennedy KJ, Kunkel SL, et al (1998) Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines. J Exp Med 187:733

64.

Kelleher P, Maroof A, Knight SC (1999) Retrovirally induced switch from production of IL-12 to IL-4 in dendritic cells. Eur J Immunol 29:2309

65.

Khoo UY, Proctor IE, Macpherson AJ (1997) CD4⁺ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J Immunol 158:3626

66.

Kopf M, Ruedl C, Schmitz N, et al (1999) OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL responses after virus infection. Immunity 11:699

67.

Kopp T, Lenz P, Bello-Fernandez C, et al (2003) IL-23 production by cosecretion of endogenous p19 and transgenic p40 in keratin 14/p40 transgenic mice: evidence for enhanced cutaneous immunity. J Immunol 170:5438

68.

Krug A, Towarowski A, Britsch S, et al (2001) Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur J Immunol 31:3026

69.

Latchman Y, Wood CR, Chernova T, et al (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2:261

70.

Lenschow DJ, Walunas TL, and Bluestone JA (1996) CD28/B7 system of T cell costimulation. Annu Rev Immunol 14:233

71.

Levings MK, Bacchetta R, Schulz U, et al (2002) The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 129:263

72.

Levings MK, Sangregorio R, Galbiati F, et al (2001) IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol 166:5530

73.

Lu B, Rutledge BJ, Gu L, et al (1998) Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187:601

74.

Luksch CR, Winqvist O, Ozaki ME, et al (1999) Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc Natl Acad Sci USA 96:3023

75.

MacDonald KP, Munster DJ, Clark GJ, et al (2002) Characterization of human blood dendritic cell subsets. Blood 100:4512

76.

Manavalan JS, Rossi PC, Vlad G, et al (2003) High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl Immunol 11:245

77.

Matsukawa A, Lukacs NW, Standiford TJ, et al (2000) Adenoviral-mediated overexpression of monocyte chemoattractant protein-1 differentially alters the development of Th1 and Th2 type responses in vivo. J Immunol 164:1699

78.

McGuirk P, McCann C, and Mills KH (2002) Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 195:221

79.

McRae BL, Semnani RT, Hayes MP, et al (1998) Type I IFNs inhibit human dendritic cell IL-12 production and Th1 cell development. J Immunol 160:4298

80.

Munder M, Mallo M, Eichmann K, et al (1998) Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J Exp Med 187:2103

81.

Murphy CA, Langrish CL, Chen Y, et al (2003) Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198:1951

82.

Murphy KM, Ouyang W, Farrar JD, et al (2000) Signaling and transcription in T helper development. Annu Rev Immunol 18:451

83.

Nieuwenhuis EE, Neurath MF, Corazza N, et al (2002) Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci USA 99:16951

84.

Nishimura H, Minato N, Nakano T, et al (1998) Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol 10:1563

85.

Nishimura H, Nose M, Hiai H, et al (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11:141

86.

Nishimura H, Okazaki T, Tanaka Y, et al (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319

87.

Ohshima Y, Tanaka Y, Tozawa H, et al (1997) Expression and function of OX40 ligand on human dendritic cells. J Immunol 159:3838

88.

Ohshima Y, Yang LP, Uchiyama T, et al (1998) OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors. Blood 92:3338

89.

Okazaki T, Maeda A, Nishimura H, et al (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci USA 98:13866

90.

Oppmann B, Lesley R, Blom B, et al (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13:715

91.

Oxenius A, Karrer U, Zinkernagel RM, et al (1999) IL-12 is not required for induction of type 1 cytokine responses in viral infections. J Immunol 162:965

92.

Parham C, Chirica M, Timans J, et al (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168:5699

93.

Parnet P, Garka KE, Bonnert TP, et al (1996) IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem 271:3967

94.

Pflanz S, Hibbert L, Mattson J, et al (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 172:2225

95.

Pflanz S, Timans JC, Cheung J, et al (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16:779

96.

Prasad DV, Richards S, Mai XM, et al (2003) B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18:863

97.

Probst HC, Lagnel J, Kollias G, et al (2003) Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8(+) T cell tolerance. Immunity 18:713

98.

Rogers PR, Song J, Gramaglia I, et al (2001) OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15:445

99.

Rogge L, Papi A, Presky DH, et al (1999) Antibodies to the IL-12 receptor beta 2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J Immunol 162:3926

100.

Salomon B, Bluestone JA (1998) LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production. J Immunol 161:5138

101.

Sato K, Yamashita N, Baba M, et al (2003) Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood 101:3581

102.

Sato K, Yamashita N, Yamashita N, et al (2003) Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 18:367

103.

Schijns VE, Haagmans BL, Wierda CM, et al (1998) Mice lacking IL-12 develop polarized Th1 cells during viral infection. J Immunol 160:3958

104.

Schlegel PG, Aharoni R, Smilek DE, et al (1994) Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules. Blood 84:2802

105.

Selenko-Gebauer N, Majdic O, Szekeres A, et al (2003) B7-h1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J Immunol 170:3637

106.

Shin T, Kennedy G, Gorski K, et al (2003) Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4⁺ T cells independent of the PD-1 receptor. J Exp Med 198:31

107.

Sica GL, Choi IH, Zhu G, et al (2003) B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18:849

108.

Smits HH, Jong EC de, Schuitemaker JH, et al (2002) Intercellular adhesion molecule-1/LFA-1 ligation favors human Th1 development. J Immunol 168:1710

109.

Smits HH, Van Beelen AJ, Hessle C, et al (2004) Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 34:1371

110.

Snijders A, Kalinski P, Hilkens CM, et al (1998) High-level IL-12 production by human dendritic cells requires two signals. Int Immunol 10:1593

111.

Steinbrink K, Wolfl M, Jonuleit H, et al (1997) Induction of tolerance by IL-10-treated dendritic cells. J Immunol 159:4772

112.

Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells. Annu Rev Immunol 21:685

113.

Suh WK, Gajewska BU, Okada H, et al (2003) The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol 4:899

114.

Takeda A, Hamano S, Yamanaka A, et al (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 170:4886

115.

Takeda K, Tsutsui H, Yoshimoto T, et al (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8:383

116.

Thierfelder WE, Deursen JM van, Yamamoto K, et al (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171

117.

Tivol EA, Borriello F, Schweitzer AN, et al (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541

118.

Traynor TR, Kuziel WA, Toews GB, et al (2000) CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J Immunol 164:2021

119.

Trinchieri G (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133

120.

Trinchieri G, Pflanz S, Kastelein RA (2003) The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19:641

121.

Tseng SY, Otsuji M, Gorski K, et al (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J Exp Med 193:839

122.

Urban BC, Roberts DJ (2002) Malaria, monocytes, macrophages and myeloid dendritic cells: sticking of infected erythrocytes switches off host cells. Curr Opin Immunol 14:458

123.

Urban BC, Willcox N, Roberts DJ (2001) A role for CD36 in the regulation of dendritic cell function. Proc Natl Acad Sci USA 98:8750

124.

Van der Kleij D, Latz E, Brouwers JF, et al (2002) A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem 277:48122

125.

Vieira PL, Jong EC de, Wierenga EA, et al (2000) Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J Immunol 164:4507

126.

Villarino A, Hibbert L, Lieberman L, et al (2003) The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19:645

127.

Vosters O, Neve J, De Wit D, et al (2003) Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory t cells. Transplantation 75:383

128.

Vremec D, Shortman K (1997) Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J Immunol 159:565

129.

Watanabe N, Gavrieli M, Sedy JR, et al (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 4:670

130.

Waterhouse P, Penninger JM, Timms E, et al (1995) Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985

131.

Yoshida H, Hamano S, Senaldi G, et al (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15:569

132.

Yvon ES, Vigouroux S, Rousseau RF, et al (2003) Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood 102:3815

133.

Zhang GX, Gran B, Yu S, et al (2003) Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 170:2153

134.

Zuany-Amorim C, Sawicka E, Manlius C, et al (2002) Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nat Med 8:625

Titel: Dendritic cell-mediated T cell polarization
verfasst von: Esther C. de Jong
Hermelijn H. Smits
Martien L. Kapsenberg
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2005
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-004-0167-1

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