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Seminars in Immunopathology

Erschienen in:

01.01.2005 | Original Article

Induction of antigen cross-presentation by Toll-like receptors

verfasst von: Sandip K. Datta, Eyal Raz

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2005

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Abstract

Cross-presentation is the pathway by which exogenous antigens are routed for presentation on MHC class I for activation of CD8⁺ T cells. This pathway is important for the development of CD8⁺ cytotoxic T lymphocyte responses against tumors and infectious pathogens that do not directly infect APC. We review studies showing that certain Toll-like receptors mediate cross-presentation by dendritic cells, initiating cytosolic processing of antigen after inducing dendritic cell maturation. The implications of these studies for understanding CD8⁺ T cell activation and implementing novel vaccine strategies is considered.

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Titel: Induction of antigen cross-presentation by Toll-like receptors
verfasst von: Sandip K. Datta
Eyal Raz
Publikationsdatum: 01.01.2005
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2005
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-004-0174-2

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