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Seminars in Immunopathology

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01.06.2007 | Review

The Th1/Th2 paradigm: still important in pregnancy?

verfasst von: Gérard Chaouat

Erschienen in: Seminars in Immunopathology | Ausgabe 2/2007

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Abstract

The enunciation of the T helper 1/T helper 2 (Th1/Th2) paradigm in pregnancy has represented a major step forward in our understanding of physiological and pathologic materno–foetal relationship. However, recent developments in studies of the implantation process and in the emergence of the uterine vascular bed and its control by natural killer cells and cytokines suggest that one must go beyond this hitherto useful scheme. In this review, we replace the emergence of the paradigm in its historical context and then emphasises what it does explain and what it no longer account for. A final reappraisal of the paradigm is suggested.

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Titel: The Th1/Th2 paradigm: still important in pregnancy?
verfasst von: Gérard Chaouat
Publikationsdatum: 01.06.2007
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 2/2007
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-007-0069-0

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