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Seminars in Immunopathology

Erschienen in:

01.09.2007 | Review

The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation

verfasst von: Ivan Tattoli, Leonardo H. Travassos, Leticia A. Carneiro, Joao G. Magalhaes, Stephen E. Girardin

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2007

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Abstract

Toll-like receptors (TLRs) and the nucleotide-binding domain, leucine rich repeat containing family (or Nod-like receptors, NLRs) are two important families of microbial sensors that are membrane-associated and cytosolic molecules, respectively. The Nod proteins Nod1 and Nod2 are two NLR family members that trigger immune defense in response to bacterial peptidoglycan. Nod proteins fight off bacterial infections by stimulating proinflammatory signaling and cytokine networks and by inducing antimicrobial effectors, such as nitric oxide and antimicrobial peptides. Nod1 is also critically implicated in shaping adaptive immune responses towards bacterial-derived constituents. In addition, recent evidence has demonstrated that mutations in Nod1 and Nod2 are associated with a number of human inflammatory disorders, including Crohn’s disease, Blau syndrome, early-onset sarcoidosis, and atopic diseases. Together, Nod1 and Nod2 represent central players in the control of immune responses to bacterial infections and inflammation.

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Titel: The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation
verfasst von: Ivan Tattoli
Leonardo H. Travassos
Leticia A. Carneiro
Joao G. Magalhaes
Stephen E. Girardin
Publikationsdatum: 01.09.2007
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2007
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-007-0083-2

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