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Erschienen in:

01.03.2021 | COVID-19 | Schwerpunkt: COVID-19 Zur Zeit gratis

COVID-19 effects on the kidney

verfasst von: Prof. Dr. K. Amann, P. Boor, T. Wiech, J. Singh, E. Vonbrunn, A. Knöll, M. Hermann, M. Büttner-Herold, C. Daniel, A. Hartmann

Erschienen in: Die Pathologie | Sonderheft 1/2021

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Abstract

Apart from pulmonary disease, acute kidney injury (AKI) is one of the most frequent and most severe organ complications in severe coronavirus disease 2019 (COVID-19). The SARS-CoV‑2 virus has been detected in renal tissue. Patients with chronic kidney disease (CKD) before and on dialysis and specifically renal transplant patients represent a particularly vulnerable population. The increasing number of COVID-19 infected patients with renal involvement led to an evolving interest in the analysis of its pathophysiology, morphology and modes of virus detection in the kidney. Meanwhile, there are ample data from several autopsy and kidney biopsy studies that differ in the quantity of cases as well as in their quality. While the detection of SARS-CoV‑2 RNA in the kidney leads to reproducible results, the use of electron microscopy for visualisation of the virus is difficult and currently critically discussed due to various artefacts. The exact contribution of indirect or direct effects on the kidney in COVID-19 are not yet known and are currently the focus of intensive research.

Zhou P et al (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798):270–273CrossRef

Gheblawi M et al (2020) Angiotensin-converting enzyme 2: SARS-coV‑2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2. Circ Res 126(10):1456–1474CrossRef

Gupta A et al (2020) Extrapulmonary manifestations of COVID-19. Nat Med 26(7):1017–1032CrossRef

Cordon-Cardo C et al (2020) COVID-19: staging of a new disease. Cancer Cell 38(5):594–597CrossRef

Wichmann D et al (2020) Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 173(4):268–277CrossRef

Zou L et al (2020) SARS-CoV‑2 viral load in upper respiratory specimens of infected patients. N Engl J Med 382(12):1177–1179CrossRef

Puelles VG et al (2020) Multiorgan and renal tropism of SARS-coV‑2. N Engl J Med 383(6):590–592. https://doi.org/10.1056/NEJMc201140CrossRefPubMed

Gavriatopoulou M et al (2020) Organ-specific manifestations of COVID-19 infection. Clin Exp Med. https://doi.org/10.1007/s10238-020-00648-xCrossRefPubMedPubMedCentral

Allison SJ (2020) SARS-CoV‑2 infection of kidney organoids prevented with soluble human ACE2. Nat Rev Nephrol 16(6):316. https://doi.org/10.1038/s41581-020-0291-8CrossRefPubMed

10.

Rubin S et al (2020) Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. Clin Kidney J 13(3):354–361PubMedPubMedCentral

11.

Richardson S et al (2020) Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 323(20):2052–2059CrossRef

12.

Zhou F et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395(10229):1054–1062CrossRef

13.

Cheng Y et al (2020) Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney Int 97(5):829–838CrossRef

14.

Jager KJ et al (2020) Results from the ERA-EDTA registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across europe. Kidney Int 98(6):1540–1548. https://doi.org/10.1016/j.kint.2020.09.006CrossRefPubMedPubMedCentral

15.

Westhoff TH et al (2020) Allograft infiltration and meningoencephalitis by SARS-CoV‑2 in a pancreas-kidney transplant recipient. Am J Transplant 20(11):3216–3220CrossRef

16.

Doevelaar AAN et al (2020) Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV‑2. J Nephrol 33(6):1369–1372CrossRef

17.

Remmelink M et al (2020) Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients. Crit Care 24(1):495CrossRef

18.

Su H et al (2020) Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int 98(1):219–227. https://doi.org/10.1016/j.kint.2020.04.003CrossRefPubMedPubMedCentral

19.

Menter T et al (2020) Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology 77(2):198–209. https://doi.org/10.1111/his.14134CrossRefPubMedPubMedCentral

20.

Santoriello D et al (2020) Postmortem kidney pathology findings in patients with COVID-19. J Am Soc Nephrol 31(9):2158–2167CrossRef

21.

Golmai P et al (2020) Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19. J Am Soc Nephrol 31(9):1944–1947CrossRef

22.

Sharma P et al (2020) COVID-19-associated kidney injury: a case series of kidney biopsy findings. J Am Soc Nephrol 31(9):1948–1958CrossRef

23.

Werion A et al (2020) SARS-coV‑2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int 98(5):1296–1307CrossRef

24.

Ronco C, Reis T (2020) Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol 16(6):308–310. https://doi.org/10.1038/s41581-020-0284-7CrossRefPubMed

25.

Risitano AM et al (2020) Complement as a target in COVID-19? Nat Rev Immunol 20(6):343–344CrossRef

26.

Leppkes M et al (2020) Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine 58:102925CrossRef

27.

Schulte-Schrepping J et al (2020) Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell 182(6):1419–1440.e23CrossRef

28.

Shetty AA et al (2020) COVID-19-associated glomerular disease. J Am Soc Nephrol 32(1):33–40. https://doi.org/10.1681/ASN.2020060804CrossRefPubMed

29.

Nadim MK et al (2020) COVID-19-associated acute kidney injury: consensus report of the 25th acute disease quality initiative (ADQI) workgroup. Nat Rev Nephrol 16(12):747–764CrossRef

30.

Nadim MK et al (2020) Publisher correction: COVID-19-associated acute kidney injury: consensus report of the 25(th) acute disease quality initiative (ADQI) workgroup. Nat Rev Nephrol 16(12):765CrossRef

31.

Best Rocha A et al (2020) Detection of SARS-CoV‑2 in formalin-fixed paraffin-embedded tissue sections using commercially available reagents. Lab Invest 100:1485–1489CrossRef

32.

Braun F et al (2020) SARS-CoV‑2 renal tropism associates with acute kidney injury. Lancet 396(10251):597–598CrossRef

33.

Farkash EA, Wilson AM, Jentzen JM (2020) Ultrastructural evidence for direct renal infection with SARS-coV‑2. J Am Soc Nephrol 31(8):1683–1687CrossRef

34.

Roufosse C et al (2020) Electron microscopic investigations in COVID-19: not all crowns are coronas. Kidney Int 98(2):505–506. https://doi.org/10.1016/j.kint.2020.05.012CrossRefPubMedPubMedCentral

35.

Hopfer H et al (2020) Hunting coronavirus by transmission electron microscopy - a guide to SARS-CoV-2-associated ultrastructural pathology in COVID-19 tissues. Histopathology. https://doi.org/10.1111/his.14264CrossRefPubMedPubMedCentral

36.

Amann K, Boor P, Wiech T (2020) COVID-19 und Nierenbefall. Nephrologe. https://doi.org/10.1007/s11560-020-00469-9CrossRefPubMedPubMedCentral

Titel: COVID-19 effects on the kidney
verfasst von: Prof. Dr. K. Amann
P. Boor
T. Wiech
J. Singh
E. Vonbrunn
A. Knöll
M. Hermann
M. Büttner-Herold
C. Daniel
A. Hartmann
Publikationsdatum: 01.03.2021
Verlag: Springer Medizin
Schlagwort: COVID-19
Erschienen in: Die Pathologie / Ausgabe Sonderheft 1/2021
Print ISSN: 2731-7188
Elektronische ISSN: 2731-7196
DOI: https://doi.org/10.1007/s00292-020-00900-x

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