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Rheumatology International

Erschienen in:

01.09.2009 | Original Paper

Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis

verfasst von: Xinwei Wang, Zhiming Lin, Qiujing Wei, Yingjuan Jiang, Jieruo Gu

Erschienen in: Rheumatology International | Ausgabe 11/2009

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Abstract

The objective of this study was to investigate the expression of IL-23 and IL-17 and the influence of IL-23 on IL-17 production in ankylosing spondylitis (AS) patients. IL-23 and IL-17 levels in the serum and supernatants of cultured peripheral blood mononuclear cells (PBMCs) were determined by ELISA. IL-23p19 mRNA expression in PBMCs were analyzed using RT-PCR. The patients with AS at active stage showed elevated levels of IL-23 and IL-17 in the serum and supernatants of cultured PBMCs. A higher expression of IL-23p19 mRNA in PBMCs of AS patients was also observed. A significantly enhanced production of IL-17 in the supernatants of cultured PBMCs was found in the presence of recombinant IL-23 and this effect was more significant in patients with AS. The results suggest that IL-23 and IL-17 may play critical roles in the pathogenesis of AS and IL-23-stimulated production of IL-17 by PBMCs may be responsible for the development of AS.

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Titel: Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis
verfasst von: Xinwei Wang
Zhiming Lin
Qiujing Wei
Yingjuan Jiang
Jieruo Gu
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 11/2009
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0883-x

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