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Rheumatology International

Erschienen in:

13.02.2019 | Review

Role of inflammation in the pathogenesis and treatment of fibromyalgia

verfasst von: Ilke Coskun Benlidayi

Erschienen in: Rheumatology International | Ausgabe 5/2019

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Abstract

Fibromyalgia is a multifaceted disease. The clinical picture of fibromyalgia covers numerous comorbidities. Each comorbidity stands as a distinct condition. However, common pathophysiologic factors are occupied in their background. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been supposed to have role in the pathogenesis of fibromyalgia. The aim of the present article was to review the current literature regarding the potential role of inflammation in the pathogenesis and treatment of fibromyalgia. A literature search was conducted through PubMed/MEDLINE and Web of Science databases using relevant keywords. Recent evidence on this highly studied topic indicates that fibromyalgia has an immunological background. Cytokines/chemokines, lipid mediators, oxidative stress and several plasma-derived factors underlie the inflammatory state in fibromyalgia. There are potential new therapeutic options targeting inflammatory pathways in fibromyalgia patients. In conclusion, there is evidence to support the inflammation-driven pathways in the pathogenesis of fibromyalgia. However, further research is required to fully understand the network of inflammation and its possible role in diagnosis and/or treatment of fibromyalgia.

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Ribeiro VGC, Mendonça VA, Souza ALC, Fonseca SF, Camargos ACR, Lage VKS, Neves CDC, Santos JM, Teixeira LAC, Vieira ELM, Teixeira Junior AL, Mezêncio B, Fernandes JSC, Leite HR, Poortmans JR, Lacerda ACR (2018) Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia. Braz J Med Biol Res 51:e6775. https://doi.org/10.1590/1414-431X20176775 CrossRefPubMedPubMedCentral

Titel: Role of inflammation in the pathogenesis and treatment of fibromyalgia
verfasst von: Ilke Coskun Benlidayi
Publikationsdatum: 13.02.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Rheumatology International / Ausgabe 5/2019
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-019-04251-6

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