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01.04.2016 | Neuro

Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia

verfasst von: Atsushi Ogasawara, Shingo Kakeda, Keita Watanabe, Satoru Ide, Issei Ueda, Yu Murakami, Junji Moriya, Koichiro Futatsuya, Toru Sato, Shingo Nakayamada, Kazuyoshi Saito, Yoshiya Tanaka, Tian Liu, Yi Wang, Yukunori Korogi

Erschienen in: European Radiology | Ausgabe 4/2016

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Abstract

Objectives

To evaluate whether quantitative susceptibility mapping (QSM) can be employed to detect abnormalities within normal-appearing basal ganglia on conventional MRI in patients with neuropsychiatric systemic lupus erythematosus (NPSLE).

Methods

For 33 SLE patients (13 NPSLE and 20 non-NPSLE patients) and 23 age/sex-matched controls, two radiologists independently measured the mean QSM and R2* values in various brain structures that appeared to be normal on conventional MR images. These values in each brain structure were compared among the two SLE groups and controls.

Results

Regarding the putamen, the NPSLE patients showed significantly higher QSM values than the non-NPSLE patients and controls (p < 0.05). For the lateral globus pallidus, both SLE groups showed significantly higher QSM values than the controls (p < 0.05). The R2* values were not significantly different between both SLE groups. The NPSLE patients showed a significant correlation between the mean QSM values in putamen and the disease duration (r = 0.63, p < 0.05). For the interobserver agreement, the QSM value was superior to the R2* value (0.690 vs. 0.446, Kendall W value).

Conclusions

QSM can be used to identify increased susceptibility of the basal ganglia appearing to be normal on conventional MR images in NPSLE patients.

Key Points

• QSM values in the putamen are significantly higher in NPSLE than non-NPSLE.

• NPSLE patients show correlation between QSM values in the putamen and disease duration.

• QSM is more sensitive than R2* mapping for detecting subtle changes.

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Titel: Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia
verfasst von: Atsushi Ogasawara
Shingo Kakeda
Keita Watanabe
Satoru Ide
Issei Ueda
Yu Murakami
Junji Moriya
Koichiro Futatsuya
Toru Sato
Shingo Nakayamada
Kazuyoshi Saito
Yoshiya Tanaka
Tian Liu
Yi Wang
Yukunori Korogi
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 4/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-015-3929-3

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Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia