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28.01.2016 | Neuro

Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results

verfasst von: Shingo Kakeda, Tetsuya Yoneda, Satoru Ide, Mari Miyata, Tomoyo Hashimoto, Koichiro Futatsuya, Keita Watanabe, Atsushi Ogasawara, Junji Moriya, Toru Sato, Kazumasa Okada, Takenori Uozumi, Hiroaki Adachi, Yukunori Korogi

Erschienen in: European Radiology | Ausgabe 11/2016

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Abstract

Objective

We compared the precentral gyri (PG) on the PADRE of patients with amyotrophic lateral sclerosis (ALS) and healthy subjects (HSs) in order to determine whether it is possible to discriminate between ALS patients and HSs on an individual basis.

Methods

First, two radiologists reviewed the appearance of the normal PG and that of ALS patients on PADRE in a non-blinded manner, and deviations from the appearance of the normal PG were recorded. Next, based on the presence of PG abnormalities on PADRE, we performed an observer performance study using 16 ALS patients and 16 HSs.

Results

The radiologists were able to consensually define the PG as abnormal on PADRE when a low-signal-intensity layer was observed in the gray matter of the PG; a three- or four-layer organization (zebra sign) was characterized by the low-signal-intensity layer. The observer performance study demonstrated that the sensitivity, specificity, and accuracy of PG abnormalities on PADRE for discriminating ALS patients from HSs were 94 %, 94 %, and 94 %, respectively, for reviewers 1 and 2.

Conclusions

It was possible to discriminate between ALS patients and HSs based on the presence of PG abnormalities on PADRE, which may reflect upper motor neuron impairment in ALS.

Key Points

• PADRE reveals low-signal-intensity layer in the PG of ALS

• By PADRE findings on PG, we can discriminate ALS from HSs

• PADRE may be a useful method for detecting UMN impairment in ALS

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Titel: Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results
verfasst von: Shingo Kakeda
Tetsuya Yoneda
Satoru Ide
Mari Miyata
Tomoyo Hashimoto
Koichiro Futatsuya
Keita Watanabe
Atsushi Ogasawara
Junji Moriya
Toru Sato
Kazumasa Okada
Takenori Uozumi
Hiroaki Adachi
Yukunori Korogi
Publikationsdatum: 28.01.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2016
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4219-4

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Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results