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12.10.2017 | Head and Neck

Is impaired cerebral vasoreactivity an early marker of cognitive decline in multiple sclerosis patients?

verfasst von: Aude Metzger, Emmanuelle Le Bars, Jeremy Deverdun, François Molino, Bénédicte Maréchal, Marie-Christine Picot, Xavier Ayrignac, Clarisse Carra, Luc Bauchet, Alexandre Krainik, Pierre Labauge, Nicolas Menjot de Champfleur

Erschienen in: European Radiology | Ausgabe 3/2018

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Abstract

Objective

The link between cerebral vasoreactivity and cognitive status in multiple sclerosis remains unclear. The aim of the present study was to investigate a potential decrease of cerebral vasoreactivity in multiple sclerosis patients and correlate it with cognitive status.

Methods

Thirty-three patients with multiple sclerosis (nine progressive and 24 remitting forms, median age: 39 years, 12 males) and 22 controls underwent MRI with a hypercapnic challenge to assess cerebral vasoreactivity and a neuropsychological assessment. Cerebral vasoreactivity, measured as the cerebral blood flow percent increase normalised by end-tidal carbon dioxide variation, was assessed globally and by regions of interest using the blood oxygen level-dependent technique. Non-parametric statistics tests were used to assess differences between groups, and associations were estimated using linear models.

Results

Cerebral vasoreactivity was lower in patients with cognitive impairment than in cognitively normal patients (p=0.004) and was associated with education level in patients (R² = 0.35; p = 0.047). There was no decrease in cerebral vasoreactivity between patients and controls.

Conclusions

Cognitive impairment in multiple sclerosis may be mediated through decreased cerebral vasoreactivity. Cerebral vasoreactivity could therefore be considered as a marker of cognitive decline in multiple sclerosis.

Key points

• Cerebral vasoreactivity does not differ between multiple sclerosis patients and controls.

• Cerebral vasoreactivity measure is linked to cognitive impairment in multiple sclerosis.

• Cerebral vasoreactivity is linked to level of education in multiple sclerosis.

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Titel: Is impaired cerebral vasoreactivity an early marker of cognitive decline in multiple sclerosis patients?
verfasst von: Aude Metzger
Emmanuelle Le Bars
Jeremy Deverdun
François Molino
Bénédicte Maréchal
Marie-Christine Picot
Xavier Ayrignac
Clarisse Carra
Luc Bauchet
Alexandre Krainik
Pierre Labauge
Nicolas Menjot de Champfleur
Publikationsdatum: 12.10.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5068-5

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Is impaired cerebral vasoreactivity an early marker of cognitive decline in multiple sclerosis patients?