Skip to main content
Erschienen in: World Journal of Urology 4/2021

19.06.2020 | Original Article

Robotic-assisted kidney transplantation in obese recipients compared to non-obese recipients: the European experience

verfasst von: Thomas Prudhomme, Jean Baptiste Beauval, Marine Lesourd, Mathieu Roumiguié, Karel Decaestecker, Graziano Vignolini, Riccardo Campi, Sergio Serni, Angelo Territo, Luis Gausa, Volkan Tugcu, Selcuk Sahin, Antonio Alcaraz, Mireia Musquera, Michael Stockle, Martin Janssen, Paolo Fornara, Nasreldin Mohammed, Arnaud Del Bello, Nassim Kamar, Federico Sallusto, Alberto Breda, Nicolas Doumerc

Erschienen in: World Journal of Urology | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The main objective was to compare minor (Clavien I–II) and major (Clavien ≥ III) intra- and postoperative complications of living donor robotic assisted kidney transplantation (RAKT) in obese (≥ 30 kg/m2 BMI), overweight (< 30/ ≥ 25 kg/m2 BMI) and non-overweight recipients (< 25 kg/m2 BMI).

Methods

For the present retrospective study, we reviewed the multi-institutional ERUS-RAKT database to select consecutive living donor RAKT recipients. Functional outcomes, intra- and postoperative complications were compared between obese, overweight and non-overweight recipients.

Results

169 living donor RAKTs were performed, by 10 surgeons, from July 2015 to September 2018 in the 8 European centers. 32 (18.9%) recipients were obese, 66 (39.1%) were overweight and 71 (42.0%) were non-overweight. Mean follow-up was 1.2 years. There were no major intra-operative complications in either study group. Conversion to open surgery occurred in 1 obese recipient, in 2 overweight recipients and no conversion occurred in non-overweight recipients (p = 0.3). Minor and major postoperative complications rates were similar in the 3 groups. At one-year of follow-up, median eGFR was similar in all groups [54 (45–60) versus 57 (46–70) versus 63 (49–78) ml/min/1.73 m2 in obese, overweight and non-overweight recipient groups, respectively, p = 0.5]. Delayed graft function rate was similar in the 3 groups. Only the number of arteries was an independent predictive factor of suboptimal renal function at post-operative day 30 in the multivariate analysis.

Conclusion

RAKT in obese recipients is safe, compared to non-overweight recipients and yields very good function, when it performed at high-volume referral centers by highly trained transplant teams.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Jensen MD, Ryan DH, Apovian CM et al (2014) American College of Cardiology/American Heart Association Task Force on Practice Guidelines; Obesity Society. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol 63(25 Pt B):2985–3023. https://doi.org/10.1016/j.jacc.2013.11.004 Jensen MD, Ryan DH, Apovian CM et al (2014) American College of Cardiology/American Heart Association Task Force on Practice Guidelines; Obesity Society. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol 63(25 Pt B):2985–3023. https://​doi.​org/​10.​1016/​j.​jacc.​2013.​11.​004
2.
Zurück zum Zitat Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, Johansen K, Kasiske B, Kutner N, Liu J, St Peter W, Guo H, Gustafson S, Heubner B, Lamb K, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Thompson B, Wang C, Weinhandl E, Zaun D, Arko C, Chen SC, Daniels F, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L (2012) United States Renal Data System 2011 annual data report: atlas of chronic kidney disease & end-stage renal disease in the United States. Am J Kidney Dis 59(1 Suppl 1):A7, e1-420. https://doi.org/10.1053/j.ajkd.2011.11.015CrossRefPubMed Collins AJ, Foley RN, Chavers B, Gilbertson D, Herzog C, Johansen K, Kasiske B, Kutner N, Liu J, St Peter W, Guo H, Gustafson S, Heubner B, Lamb K, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Thompson B, Wang C, Weinhandl E, Zaun D, Arko C, Chen SC, Daniels F, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L (2012) United States Renal Data System 2011 annual data report: atlas of chronic kidney disease & end-stage renal disease in the United States. Am J Kidney Dis 59(1 Suppl 1):A7, e1-420. https://​doi.​org/​10.​1053/​j.​ajkd.​2011.​11.​015CrossRefPubMed
8.
Zurück zum Zitat Meier-Kriesche HU, Arndorfer JA, Kaplan B (2002) The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death. Transplantation 73(1):70–74CrossRef Meier-Kriesche HU, Arndorfer JA, Kaplan B (2002) The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient death. Transplantation 73(1):70–74CrossRef
13.
Zurück zum Zitat Territo A, Gausa L, Alcaraz A, Musquera M, Doumerc N, Decaestecker K, Desender L, Stockle M, Janssen M, Fornara P, Mohammed N, Siena G, Serni S, Sahin S, Tugcu V, Basile G, Breda A (2018) European experience of robot-assisted kidney transplantation: minimum of 1-year follow-up. BJU Int 122(2):255–262. https://doi.org/10.1111/bju.14247CrossRefPubMed Territo A, Gausa L, Alcaraz A, Musquera M, Doumerc N, Decaestecker K, Desender L, Stockle M, Janssen M, Fornara P, Mohammed N, Siena G, Serni S, Sahin S, Tugcu V, Basile G, Breda A (2018) European experience of robot-assisted kidney transplantation: minimum of 1-year follow-up. BJU Int 122(2):255–262. https://​doi.​org/​10.​1111/​bju.​14247CrossRefPubMed
14.
Zurück zum Zitat Oberholzer J, Giulianotti P, Danielson KK, Spaggiari M, Bejarano-Pineda L, Bianco F, Tzvetanov I, Ayloo S, Jeon H, Garcia-Roca R, Thielke J, Tang I, Akkina S, Becker B, Kinzer K, Patel A, Benedetti E (2013) Minimally invasive robotic kidney transplantation for obese patients previously denied access to transplantation. Am J Transplant 13(3):721–728. https://doi.org/10.1111/ajt.12078CrossRefPubMedPubMedCentral Oberholzer J, Giulianotti P, Danielson KK, Spaggiari M, Bejarano-Pineda L, Bianco F, Tzvetanov I, Ayloo S, Jeon H, Garcia-Roca R, Thielke J, Tang I, Akkina S, Becker B, Kinzer K, Patel A, Benedetti E (2013) Minimally invasive robotic kidney transplantation for obese patients previously denied access to transplantation. Am J Transplant 13(3):721–728. https://​doi.​org/​10.​1111/​ajt.​12078CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Spaggiari M, Lendacki FR, Di Bella C, Giulianotti PC, Benedetti E, Oberholzer J, Tzvetanov I (2018) Minimally invasive, robot-assisted procedure for kidney transplantation among morbidly obese: Positive outcomes at 5 years post-transplant. Clin Transplant 32(11):e13404. https://doi.org/10.1111/ctr.13404CrossRefPubMed Spaggiari M, Lendacki FR, Di Bella C, Giulianotti PC, Benedetti E, Oberholzer J, Tzvetanov I (2018) Minimally invasive, robot-assisted procedure for kidney transplantation among morbidly obese: Positive outcomes at 5 years post-transplant. Clin Transplant 32(11):e13404. https://​doi.​org/​10.​1111/​ctr.​13404CrossRefPubMed
18.
Zurück zum Zitat Siena G, Campi R, Decaestecker K, Tugcu V, Sahin S, Alcaraz A, Musquera M, Territo A, Gausa L, Randon C, Stockle M, Janssen M, Fornara P, Mohammed N, Guirado L, Facundo C, Doumerc N, Vignolini G, Breda A, Serni S (2018) Robot-assisted kidney transplantation with regional hypothermia using grafts with multiple vessels after extracorporeal vascular reconstruction: results from the European Association of Urology Robotic Urology Section Working Group. Eur Urol Focus 4(2):175–184. https://doi.org/10.1016/j.euf.2018.07.022CrossRefPubMed Siena G, Campi R, Decaestecker K, Tugcu V, Sahin S, Alcaraz A, Musquera M, Territo A, Gausa L, Randon C, Stockle M, Janssen M, Fornara P, Mohammed N, Guirado L, Facundo C, Doumerc N, Vignolini G, Breda A, Serni S (2018) Robot-assisted kidney transplantation with regional hypothermia using grafts with multiple vessels after extracorporeal vascular reconstruction: results from the European Association of Urology Robotic Urology Section Working Group. Eur Urol Focus 4(2):175–184. https://​doi.​org/​10.​1016/​j.​euf.​2018.​07.​022CrossRefPubMed
22.
Zurück zum Zitat Sood A, Hakim DN, Hakim NS (2016) Consequences of recipient obesity on postoperative outcomes in a renal transplant: a systematic review and meta-analysis. Exp Clin Transplant 14(2):121–128PubMed Sood A, Hakim DN, Hakim NS (2016) Consequences of recipient obesity on postoperative outcomes in a renal transplant: a systematic review and meta-analysis. Exp Clin Transplant 14(2):121–128PubMed
25.
Zurück zum Zitat Freeman CM, Woodle ES, Shi J, Alexander JW, Leggett PL, Shah SA, Paterno F, Cuffy MC, Govil A, Mogilishetty G, Alloway RR, Hanseman D, Cardi M, Diwan TS (2015) Addressing morbid obesity as a barrier to renal transplantation with laparoscopic sleeve gastrectomy. Am J Transplant 15(5):1360–1368. https://doi.org/10.1111/ajt.13116CrossRefPubMed Freeman CM, Woodle ES, Shi J, Alexander JW, Leggett PL, Shah SA, Paterno F, Cuffy MC, Govil A, Mogilishetty G, Alloway RR, Hanseman D, Cardi M, Diwan TS (2015) Addressing morbid obesity as a barrier to renal transplantation with laparoscopic sleeve gastrectomy. Am J Transplant 15(5):1360–1368. https://​doi.​org/​10.​1111/​ajt.​13116CrossRefPubMed
30.
Zurück zum Zitat Zorgdrager M, Krikke C, Hofker SH, Leuvenink HG, Pol RA (2016) Multiple renal arteries in kidney transplantation: a systematic review and meta-analysis. Ann Transplant 21:469–478CrossRef Zorgdrager M, Krikke C, Hofker SH, Leuvenink HG, Pol RA (2016) Multiple renal arteries in kidney transplantation: a systematic review and meta-analysis. Ann Transplant 21:469–478CrossRef
Metadaten
Titel
Robotic-assisted kidney transplantation in obese recipients compared to non-obese recipients: the European experience
verfasst von
Thomas Prudhomme
Jean Baptiste Beauval
Marine Lesourd
Mathieu Roumiguié
Karel Decaestecker
Graziano Vignolini
Riccardo Campi
Sergio Serni
Angelo Territo
Luis Gausa
Volkan Tugcu
Selcuk Sahin
Antonio Alcaraz
Mireia Musquera
Michael Stockle
Martin Janssen
Paolo Fornara
Nasreldin Mohammed
Arnaud Del Bello
Nassim Kamar
Federico Sallusto
Alberto Breda
Nicolas Doumerc
Publikationsdatum
19.06.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
World Journal of Urology / Ausgabe 4/2021
Print ISSN: 0724-4983
Elektronische ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-020-03309-6

Weitere Artikel der Ausgabe 4/2021

World Journal of Urology 4/2021 Zur Ausgabe

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

16.05.2024 alpha-1-Rezeptorantagonisten Nachrichten

Nach einer Prostatabiopsie treten häufig Probleme beim Wasserlassen auf. Ob sich das durch den periinterventionellen Einsatz von Alphablockern verhindern lässt, haben australische Mediziner im Zuge einer Metaanalyse untersucht.

S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Viel pflanzliche Nahrung, seltener Prostata-Ca.-Progression

12.05.2024 Prostatakarzinom Nachrichten

Ein hoher Anteil pflanzlicher Nahrung trägt möglicherweise dazu bei, das Progressionsrisiko von Männern mit Prostatakarzinomen zu senken. In einer US-Studie war das Risiko bei ausgeprägter pflanzlicher Ernährung in etwa halbiert.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.