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01.07.2014 | Original Article

Impacts of age on coronary atherosclerosis and vascular response to statin therapy

verfasst von: Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Tsutomu Hirano, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

Erschienen in: Heart and Vessels | Ausgabe 4/2014

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Abstract

Age is a well-established risk factor for cardiovascular disease. Recent trials using intravascular ultrasound (IVUS) have shown that lipid-lowering therapy with statins halts the progression or induces the regression of coronary artery plaques. However, impacts of age on coronary atherosclerosis and vascular response to statin therapy have not been fully evaluated. The effects of 8-month statin therapy on coronary atherosclerosis were evaluated using virtual histology-IVUS. IVUS data were analyzed from 119 patients who were divided into two groups according to age: elderly patients (≥65 years, n = 72) and non-elderly patients (<65 years, n = 47). No patients were taking statins or other lipid-lowering therapies at baseline. At baseline, external elastic membrane (EEM) volume (17.27 vs. 14.95 mm³/mm, p = 0.02) and plaque volume (9.49 vs. 8.11 mm³/mm, p = 0.03) in the elderly patients were significantly greater than in the non-elderly patients. The EEM volume (−2.4 %, p = 0.007) and plaque volume (−3.1 %, p = 0.007) after 8-month of statin therapy had significantly decreased in the non-elderly patients but not in the elderly patients. A significant positive correlation was observed between age and percentage change in plaque volume (r = 0.265, p = 0.004). A multivariate regression analysis showed that age was a significant predictor of the percentage change in plaque volume during statin therapy (β = 0.223, p = 0.02). Coronary atherosclerosis was more advanced and vascular responses to statin therapy were attenuated in the elderly patients compared to the non-elderly patients.

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Titel: Impacts of age on coronary atherosclerosis and vascular response to statin therapy
verfasst von: Tsuyoshi Nozue
Shingo Yamamoto
Shinichi Tohyama
Kazuki Fukui
Shigeo Umezawa
Yuko Onishi
Tomoyuki Kunishima
Akira Sato
Toshihiro Nozato
Shogo Miyake
Youichi Takeyama
Yoshihiro Morino
Takao Yamauchi
Toshiya Muramatsu
Tsutomu Hirano
Kiyoshi Hibi
Mitsuyasu Terashima
Ichiro Michishita
Publikationsdatum: 01.07.2014
Verlag: Springer Japan
Erschienen in: Heart and Vessels / Ausgabe 4/2014
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-013-0387-1

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