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Pediatric Surgery International

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01.08.2010 | Original Article

The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants

verfasst von: Merih Çetinkaya, Hilal Özkan, Nilgün Köksal, Okan Akacı, Taner Özgür

Erschienen in: Pediatric Surgery International | Ausgabe 8/2010

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Abstract

Purpose

The purpose of this study was to evaluate the efficacy of serial serum amyloid A (SAA) measurements in diagnosis and follow-up of necrotizing enterocolitis (NEC) in preterm infants.

Methods

A total of 144 infants were enrolled in this observational study. The infants were classified into three groups: group 1 (infants with NEC and sepsis), group 2 (infants with sepsis), and group 3 (no sepsis and NEC, control group). Data including serial whole blood count (WBC), SAA measurements that were obtained at the initial work-up of NEC and/or sepsis episode (0 day), at 24, 48 h, 7, and 10 day were evaluated. In addition, initial and serial follow-up abdominal radiographies were obtained.

Results

A total of 50 infants were diagnosed NEC. Mean SAA values (43.2 ± 47.5 mg/dl) of infants in group 1 at 0 h were significantly higher than those in group 2 and group 3. The percentage of infants with abnormal SAA levels was significantly higher in group 1 compared with that in group 2 at 24 h. In addition, the percentage of infants with abnormal SAA levels was slightly but not statistically higher in stage 2 and stage 3 NEC group compared with that stage 1 NEC at 0, 24, 48 h. SAA levels started to decline at 48 h of onset through day 10. The cut-off value for SAA for differentiating NEC from sepsis was 23.2 mg/dl.

Conclusion

SAA may be recognized as an accurate laboratory marker in addition to clinical and radiographic findings for NEC diagnosis. It can also be used for determining the severity of NEC and response to therapy in infants with NEC.

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Titel: The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants
verfasst von: Merih Çetinkaya
Hilal Özkan
Nilgün Köksal
Okan Akacı
Taner Özgür
Publikationsdatum: 01.08.2010
Verlag: Springer-Verlag
Erschienen in: Pediatric Surgery International / Ausgabe 8/2010
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-010-2635-0

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The efficacy of serial serum amyloid A measurements for diagnosis and follow-up of necrotizing enterocolitis in premature infants

Abstract

Purpose

Methods

Results

Conclusion

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