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01.04.2014 | Original Contribution

Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study

verfasst von: Tilman Kühn, Rudolf Kaaks, Birgit Teucher, Frank Hirche, Jutta Dierkes, Cornelia Weikert, Verena Katzke, Heiner Boeing, Gabriele I. Stangl, Brian Buijsse

Erschienen in: European Journal of Nutrition | Ausgabe 3/2014

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Abstract

Purpose

Considerable variation in 25-hydroxyvitamin D (25(OH)D) in populations worldwide that seems to be independent of latitude has been reported. Therefore, we aimed to assess vitamin D status of a mid-aged German general population and to identify its dietary, lifestyle, anthropometric, and genetic determinants.

Methods

25(OH)D concentrations were measured by LC–MS/MS in plasma samples of a random subcohort of the German arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) comprising 2,100 subjects aged 35–65 years. Associations between potential predictors and 25(OH)D were assessed by linear regression models.

Results

32.8 % of the variance in 25(OH)D was explained by a multivariable regression model, with season being the by far strongest predictor (semi-partial R ²: 14.6 %). Sex, waist circumference, leisure time physical activity, smoking, polymorphisms in the GC, CYP2R1, and DHCR7 genes, supplement use, exogenous hormone use, alcohol consumption, egg consumption, and fish consumption were significantly associated with 25(OH)D concentrations as well. However, none of these factors explained >2.3 % of the variance in 25(OH)D.

Conclusion

Even with a comprehensive set of genetic, anthropometric, dietary, and lifestyle correlates, not more than 32.8 % of the variation in 25(OH)D could be explained in the EPIC-Germany study, implying that vitamin D prediction scores may not provide an appropriate proxy for measured 25(OH)D. Food intake was only a weak predictor of 25(OH)D concentrations, while a strong seasonal fluctuation in 25(OH)D was shown.

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Titel: Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study
verfasst von: Tilman Kühn
Rudolf Kaaks
Birgit Teucher
Frank Hirche
Jutta Dierkes
Cornelia Weikert
Verena Katzke
Heiner Boeing
Gabriele I. Stangl
Brian Buijsse
Publikationsdatum: 01.04.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 3/2014
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-013-0577-8

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Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study

Abstract

Purpose

Methods

Results

Conclusion

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