Erschienen in:
01.04.2014 | Correspondence
Supratentorial ependymomas of childhood carry C11orf95–RELA fusions leading to pathological activation of the NF-κB signaling pathway
verfasst von:
Torsten Pietsch, Inken Wohlers, Tobias Goschzik, Verena Dreschmann, Dorota Denkhaus, Evelyn Dörner, Sven Rahmann, Ludger Klein-Hitpass
Erschienen in:
Acta Neuropathologica
|
Ausgabe 4/2014
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Excerpt
Clinical observations and studies on genetic alterations and gene expression indicated that supratentorial ependymomas differ from ependymomas of infratentorial or spinal location [
6,
8]. To further elucidate the pathogenesis of supratentorial ependymomas, we performed paired-end RNA sequencing in 19 tumor samples from 18 patients (for clinical data, see Supplementary Table 1). Mapping of the reads predicted a novel recurrent fusion mRNA between
C11orf95, a gene with unknown function, and
v-rel avian reticuloendotheliosis viral oncogene homolog A (
RELA) encoding the RelA p65 subunit of the central NF-κB complex.
RELA is located approximately 1.9 Mbp telomeric from
C11orf95 on the same chromosomal band 11q13. …