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Erschienen in:
01.02.2016 | Erratum
Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity
Erschienen in: Acta Neuropathologica | Ausgabe 2/2016
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The original version of this article contained errors in the alignment of several entries in Tables 4 and 5. The corrected Tables 4 and 5 are given below. The original article has been updated accordingly.
Table 4
Univariate and multivariate Cox regression analysis regarding overall survival and single genetic factors
|
Median survival in months
|
Risk ratio (lower–upper 95 % CI)
|
p
|
||
|---|---|---|---|---|
|
Condition 1
|
Condition 2
|
Condition 1 vs. condition 2
|
||
|
Univariate analysis
|
||||
|
MGMT promoter status
|
Methylated
|
Unmethylated
|
0.09 (0.02–0.44)
|
0.004
|
|
>37.1
|
8.9
|
|||
|
IDH/CIMP status
|
Mutant/positive
|
Wildtype/negative
|
0.31 (0.08–1.23)
|
0.08
|
|
36.3
|
14.1
|
|||
|
1p/19q status
|
Codeleted
|
Not codeleted
|
||
|
>16.5
|
34.8
|
0.44 (0.05–3.6)
|
0.44
|
|
|
Chromosome 7 gain
|
Yes
|
No
|
6.32 (1.78–22.5)
|
0.004
|
|
8.98
|
>36.3
|
|||
|
EGFR amplification
|
Yes
|
No
|
10.1 (2.0–51.1)
|
0.005
|
|
7.9
|
36.3
|
|||
|
9p21 deletion
|
Yes
|
No
|
1.15 (0.33–4.0)
|
0.82
|
|
37.1
|
34.6
|
|||
|
Chromosome 10 deletion
|
Yes
|
No
|
2.6 (0.77–8.73)
|
0.12
|
|
12.2
|
36.3
|
|||
|
CDK4 amplification
|
Yes
|
No
|
0.52 (0.1–2.6)
|
0.42
|
|
36.2
|
34.6
|
|||
|
MDM2 or MDM4 amplification
|
Yes
|
No
|
1.06 (0.28–4.1)
|
0.93
|
|
14.1
|
34.6
|
|||
|
Multivariate analysis
|
||||
|
MGMT promoter status
|
Methylated
|
Unmethylated
|
0.16 (0.03–0.95)
|
0.04
|
|
IDH/CIMP status
|
Mutant/positive
|
Wildtype/negative
|
1.27 (0.14–11.6)
|
0.83
|
|
Chromosome 7 gain
|
Yes
|
No
|
4.2 (0.49–36.3)
|
0.19
|
|
EGFR amplification
|
Yes
|
No
|
3.0 (0.56–16.3)
|
0.20
|
Table 5
Univariate Cox regression analysis regarding the prognostic value MRI features for overall survival
|
MRI appearance
|
HR
|
95 % CI
|
p
|
|---|---|---|---|
|
Infratentorial involvement, yes vs. no
|
0.4
|
0.05–3.1
|
0.38
|
|
Involvement of 6 or more lobes, yes vs. no
|
1.08
|
0.33–3.5
|
0.9
|
|
Bilateral involvement, yes vs. no
|
0.67
|
0.08–5.4
|
0.71
|
|
Contrast enhancing lesionsa, yes vs. no
|
1.39
|
0.37–5.3
|
0.63
|