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Archives of Dermatological Research

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01.04.2008 | Original Paper

By the grace of peeling: the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis

verfasst von: Teruki Dainichi, Setsuko Ueda, Masutaka Furue, Takashi Hashimoto

Erschienen in: Archives of Dermatological Research | Sonderheft 1/2008

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Abstract

Chemical peeling with salicylic acid in polyethylene glycol vehicle (SA-PEG) is a safe and effective method for the rejuvenation of photo-damaged skin. The procedure removes photo-damaged stratum corneum, which consists of immature, fragile cornified envelopes (CEs) and stimulates the reconstruction of the stratum corneum with mature, rigid CEs. In UVB-irradiated hairless mice this procedure, which affects the stratum corneum only, suppresses skin tumor development. In addition, chemical peeling with SA-PAG suppresses p53 expression in mice and normalizes keratinocyte differentiation in both mice and humans. The stratum corneum functions as a barrier against physical and chemical insult and various infectious agents. Here, we hypothesize on a new function of the stratum corneum: a brace function that structurally protects keratinocytes from atypical differentiation or disordered proliferation. Although the precise mechanism remains to be elucidated, there is definite value to be gained from further investigation. This review discusses basic information about chemical peeling with SA-PEG, looks at its action on photo-induced tumor suppression, and proposes a new function for the stratum corneum in keratinocyte proliferation/differentiation.

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Titel: By the grace of peeling: the brace function of the stratum corneum in the protection from photo-induced keratinocyte carcinogenesis
verfasst von: Teruki Dainichi
Setsuko Ueda
Masutaka Furue
Takashi Hashimoto
Publikationsdatum: 01.04.2008
Verlag: Springer-Verlag
Erschienen in: Archives of Dermatological Research / Ausgabe Sonderheft 1/2008
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-007-0802-5

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