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Archives of Gynecology and Obstetrics

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01.11.2007 | Review Article

Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review

verfasst von: Deepti Cheema, Arri Coomarasamy, Tarek El-Toukhy

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 5/2007

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Abstract

Background

Interest in non-hormonal therapies for the treatment of menopausal symptoms has increased since the publication of adverse effects of estrogen replacement therapy.

Objective

To provide information on the efficacy of non-hormonal therapies for menopausal vasomotor symptoms based on evidence from published randomised controlled studies.

Methods

The Cochrane Database of Systematic Reviews (CDSR), MEDLINE, Alternative Therapies in Health and Medicine database (ATHMD) and Allied and Complementary Medicine database (AMED) were searched for randomised controlled trials in the English language reporting data on treatment of menopausal vasomotor symptoms. Trials including cancer breast patients were included.

Results

Our search identified 58 randomised controlled trials of which 11 involved the use of clonidine, six for SSRIs, four for gabapentin, seven for black cohosh, seven for red clover, 18 for phytoestrogens, two for ginseng, one for evening primrose, one for dong quai and one for vitamin E. Most trials had methodological deficiencies.

Conclusion

There is evidence that clonidine, paroxetine, venlafaxine, gabapentin and black cohosh may be beneficial in the treatment of menopausal vasomotor symptoms in some women. Current evidence does not support the use of fluoxetine, red clover, phytoestrogens, Ginseng, evening primrose, dong quai and vitamin E. The side effects profile of these therapies should be considered.

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Titel: Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review
verfasst von: Deepti Cheema
Arri Coomarasamy
Tarek El-Toukhy
Publikationsdatum: 01.11.2007
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 5/2007
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-007-0390-9

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Springer Medizin

Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review

Abstract

Background

Objective

Methods

Results

Conclusion

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Springer Medizin

Abstract

Background

Objective

Methods

Results

Conclusion

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