Skip to main content
Erschienen in: Archives of Gynecology and Obstetrics 2/2011

01.08.2011 | Materno-Fetal Medicine

Is induced labour in the nullipara associated with more maternal and perinatal morbidity?

verfasst von: Dan Selo-Ojeme, Cathy Rogers, Ashok Mohanty, Naseem Zaidi, Rose Villar, Panicos Shangaris

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 2/2011

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To ascertain any differences in foetomaternal outcomes in induced and spontaneous labour among nulliparous women delivering at term.

Methods

A retrospective matched cohort study consisting of 403 nulliparous women induced at ≥292 days and 806 nulliparous women with spontaneous labour at 285–291 days.

Results

Compared to those in spontaneous labour, women who had induction of labour were three times more likely to have a caesarean delivery (OR 3.1, 95% CI 2.4–4.1; P < 0.001). Women who had induction of labour were 2.2 times more likely to have oxytocin augmentation (OR 2.2, 95% CI 1.7–2.8; P < 0.001), 3.6 times more likely to have epidural anaesthesia (OR 3.6, 95% CI 2.8–4.6; P < 0.001), 1.7 times more likely to have uterine hyperstimulation (OR 1.7, 95% CI 1.1–2.6), 2 times more likely to have a suspicious foetal heart rate trace (OR 2.0, 95% CI 1.5–2.6), 4.1 times more likely to have blood loss over 500 ml (OR 4.1, 95% CI 2.95.5; P < 0.001), and 2.9 times more likely to stay in hospital beyond 5 days (OR 2.9, 95% CI 1.5–5.6; P < 0.001). Babies born to mothers who had induction of labour were significantly more likely to have an Apgar score of <5 at 5 min and an arterial cord pH of <7.0.

Conclusion

Compared to those with spontaneous labour, nulliparous women with induced labours are more likely to have uterine hyperstimulation, caesarean delivery, and babies with low Apgar scores. Nulliparous women should be made aware of this, as well as potential risks of expectant management during counseling.
Literatur
1.
Zurück zum Zitat Government Statistical Service for the Department of Health (2009) NHS maternity statistics, England: 2007–2008 Government Statistical Service for the Department of Health (2009) NHS maternity statistics, England: 2007–2008
2.
Zurück zum Zitat National Institute for Clinical Excellence (2001) Clinical guideline D: induction of labor. National Institute for Clinical Excellence, London National Institute for Clinical Excellence (2001) Clinical guideline D: induction of labor. National Institute for Clinical Excellence, London
3.
Zurück zum Zitat Cammu H, Martens G, Ruyssinck G, Amy JJ (2002) Outcome after elective labor induction in nulliparous women: a matched cohort study. Am J Obstet Gynecol 186(2):240–244PubMedCrossRef Cammu H, Martens G, Ruyssinck G, Amy JJ (2002) Outcome after elective labor induction in nulliparous women: a matched cohort study. Am J Obstet Gynecol 186(2):240–244PubMedCrossRef
4.
Zurück zum Zitat Seyb ST, Berka RJ, Socol ML, Dooley SL (1999) Risk of caesarean delivery with elective induction of labour at term in nulliparous women. Obstet Gynecol 94(4):600–607PubMedCrossRef Seyb ST, Berka RJ, Socol ML, Dooley SL (1999) Risk of caesarean delivery with elective induction of labour at term in nulliparous women. Obstet Gynecol 94(4):600–607PubMedCrossRef
5.
Zurück zum Zitat Luthy DA, Malmgren JA, Zingheim RW (2004) Caesarean delivery after elective induction in nulliparous women: the physician effect. Am J Obstet Gynecol 191(5):1511–1515PubMedCrossRef Luthy DA, Malmgren JA, Zingheim RW (2004) Caesarean delivery after elective induction in nulliparous women: the physician effect. Am J Obstet Gynecol 191(5):1511–1515PubMedCrossRef
6.
Zurück zum Zitat Vrouenraets FP, Roumen FJ, Dehing CJ, van den Akker ES, Aarts MJ, Scheve EJ (2005) Bishop score and risk of caesarean delivery after induction of labour in nulliparous women. Obstet Gynecol 105(4):690–697PubMedCrossRef Vrouenraets FP, Roumen FJ, Dehing CJ, van den Akker ES, Aarts MJ, Scheve EJ (2005) Bishop score and risk of caesarean delivery after induction of labour in nulliparous women. Obstet Gynecol 105(4):690–697PubMedCrossRef
7.
Zurück zum Zitat Vahratian A, Zhang J, Troendle JF, Sciscione AC, Hoffman MK (2005) Labour progression and risk of caesarean delivery in electively induced nulliparas. Obstet Gynecol 105(4):698–704PubMedCrossRef Vahratian A, Zhang J, Troendle JF, Sciscione AC, Hoffman MK (2005) Labour progression and risk of caesarean delivery in electively induced nulliparas. Obstet Gynecol 105(4):698–704PubMedCrossRef
8.
Zurück zum Zitat Yeast JD, Jones A, Poskin M (1999) Induction of labour and the relationship to caesarean delivery: a review of 7001 consecutive inductions. Am J Obstet Gynecol 180(3 Pt 1):628–633PubMedCrossRef Yeast JD, Jones A, Poskin M (1999) Induction of labour and the relationship to caesarean delivery: a review of 7001 consecutive inductions. Am J Obstet Gynecol 180(3 Pt 1):628–633PubMedCrossRef
9.
Zurück zum Zitat Prysak M, Castronova FC (1998) Elective induction versus spontaneous labour: a case control analysis of safety and efficacy. Obstet Gynecol 92(1):47–52PubMedCrossRef Prysak M, Castronova FC (1998) Elective induction versus spontaneous labour: a case control analysis of safety and efficacy. Obstet Gynecol 92(1):47–52PubMedCrossRef
10.
Zurück zum Zitat Gülmezoglu AM (2006) Induction of labour for improving birth outcomes for women at or beyond term. Cochrane Database Syst Rev 18(4):CD004945 Gülmezoglu AM (2006) Induction of labour for improving birth outcomes for women at or beyond term. Cochrane Database Syst Rev 18(4):CD004945
11.
Zurück zum Zitat Caughey AB, Sundaram V, Kaimal AJ, Gienger A, Cheng YW, McDonald KM, Shaffer BL, Owens DK, Bravata DM (2009) Systematic review: elective induction of labor versus expectant management of pregnancy. Ann Intern Med 151(4):252–263 W53–W63 (review)PubMed Caughey AB, Sundaram V, Kaimal AJ, Gienger A, Cheng YW, McDonald KM, Shaffer BL, Owens DK, Bravata DM (2009) Systematic review: elective induction of labor versus expectant management of pregnancy. Ann Intern Med 151(4):252–263 W53–W63 (review)PubMed
12.
Zurück zum Zitat Sanchez-Ramos L, Olivier F, Delke I, Kaunitz AM (2003) Labor induction versus expectant management for postterm pregnancies: a systematic review with meta-analysis. Obstet Gynecol 101(6):1312–1318PubMedCrossRef Sanchez-Ramos L, Olivier F, Delke I, Kaunitz AM (2003) Labor induction versus expectant management for postterm pregnancies: a systematic review with meta-analysis. Obstet Gynecol 101(6):1312–1318PubMedCrossRef
13.
Zurück zum Zitat Hannah ME, Hannah WJ, Hellmann J, Hewson S, Milner R, Willan A (1992) Induction of labor as compared with serial antenatal monitoring in post-term pregnancy. A randomized controlled trial. The Canadian Multicenter Post-term Pregnancy Trial Group. N Engl J Med 326(24):1587–1592 (Erratum in: N Engl J Med 30;327)PubMedCrossRef Hannah ME, Hannah WJ, Hellmann J, Hewson S, Milner R, Willan A (1992) Induction of labor as compared with serial antenatal monitoring in post-term pregnancy. A randomized controlled trial. The Canadian Multicenter Post-term Pregnancy Trial Group. N Engl J Med 326(24):1587–1592 (Erratum in: N Engl J Med 30;327)PubMedCrossRef
14.
Zurück zum Zitat Bodner-Adler B, Bodner K, Pateisky N, Kimberger O, Chalubinski K, Mayerhofer K, Husslein P (2005) Influence of labor induction on obstetric outcomes in patients with prolonged pregnancy: a comparison between elective labor induction and spontaneous onset of labor beyond term. Wien Klin Wochenschr 117(7–8):287–292PubMedCrossRef Bodner-Adler B, Bodner K, Pateisky N, Kimberger O, Chalubinski K, Mayerhofer K, Husslein P (2005) Influence of labor induction on obstetric outcomes in patients with prolonged pregnancy: a comparison between elective labor induction and spontaneous onset of labor beyond term. Wien Klin Wochenschr 117(7–8):287–292PubMedCrossRef
15.
Zurück zum Zitat Glantz JC (2005) Elective induction vs. spontaneous labor associations and outcomes. J Reprod Med 50(4):235–240PubMed Glantz JC (2005) Elective induction vs. spontaneous labor associations and outcomes. J Reprod Med 50(4):235–240PubMed
16.
Zurück zum Zitat Beebe L, Beaty C, Rayburn W (2007) Immediate neonatal outcomes after elective induction of labor. J Reprod Med 52(3):173–175PubMed Beebe L, Beaty C, Rayburn W (2007) Immediate neonatal outcomes after elective induction of labor. J Reprod Med 52(3):173–175PubMed
17.
Zurück zum Zitat Maslow AS, Sweeny AL (2000) Elective induction of labor as a risk factor for cesarean delivery among low-risk women at term. Obstet Gynecol 95(6 Pt 1):917–922PubMedCrossRef Maslow AS, Sweeny AL (2000) Elective induction of labor as a risk factor for cesarean delivery among low-risk women at term. Obstet Gynecol 95(6 Pt 1):917–922PubMedCrossRef
18.
Zurück zum Zitat National Institute for Health and Clinical Excellence (2008) Clinical guideline D: induction of labor. National Institute for Health and Clinical Excellence, London National Institute for Health and Clinical Excellence (2008) Clinical guideline D: induction of labor. National Institute for Health and Clinical Excellence, London
19.
Zurück zum Zitat Lin MG, Rouse DJ (2006) Clinical obstetrics and gynaecology 49(3):585–593 Lin MG, Rouse DJ (2006) Clinical obstetrics and gynaecology 49(3):585–593
20.
Zurück zum Zitat Selo-Ojeme D, Pisal P, Lawal O, Rogers C, Shah A, Sinha S (2009) A randomised controlled trial of amniotomy and immediate oxytocin infusion versus amniotomy and delayed oxytocin infusion for induction of labor at term. Arch Gynaecol Obstet 276(6):813–820CrossRef Selo-Ojeme D, Pisal P, Lawal O, Rogers C, Shah A, Sinha S (2009) A randomised controlled trial of amniotomy and immediate oxytocin infusion versus amniotomy and delayed oxytocin infusion for induction of labor at term. Arch Gynaecol Obstet 276(6):813–820CrossRef
21.
Zurück zum Zitat Egarter CH, Husslein PW, Rayburn WF (1990) Uterine hyperstimulation after low dose prostaglandin E2 therapy: tocolytic treatment in 181 cases. Am J Obstet Gynecol 63(3):794–796 Egarter CH, Husslein PW, Rayburn WF (1990) Uterine hyperstimulation after low dose prostaglandin E2 therapy: tocolytic treatment in 181 cases. Am J Obstet Gynecol 63(3):794–796
22.
Zurück zum Zitat van Gemund N, Hardeman A, Scherjon SA, Kanhai HH (2003) Intervention rates after elective induction of labor compared to labor with a spontaneous onset. A matched cohort study. Gynecol Obstet Invest 56(3):133–138PubMedCrossRef van Gemund N, Hardeman A, Scherjon SA, Kanhai HH (2003) Intervention rates after elective induction of labor compared to labor with a spontaneous onset. A matched cohort study. Gynecol Obstet Invest 56(3):133–138PubMedCrossRef
23.
Zurück zum Zitat Svärdby K, Nordström L, Sellström E (2007) Primiparas with or without oxytocin augmentation: a prospective descriptive study. J Clin Nurs 16(1):179–184PubMedCrossRef Svärdby K, Nordström L, Sellström E (2007) Primiparas with or without oxytocin augmentation: a prospective descriptive study. J Clin Nurs 16(1):179–184PubMedCrossRef
24.
Zurück zum Zitat Macones GA (2009) Elective induction of labour: waking a sleeping dogma? Ann Intern Med 151:281–282PubMed Macones GA (2009) Elective induction of labour: waking a sleeping dogma? Ann Intern Med 151:281–282PubMed
Metadaten
Titel
Is induced labour in the nullipara associated with more maternal and perinatal morbidity?
verfasst von
Dan Selo-Ojeme
Cathy Rogers
Ashok Mohanty
Naseem Zaidi
Rose Villar
Panicos Shangaris
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 2/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-010-1671-2

Weitere Artikel der Ausgabe 2/2011

Archives of Gynecology and Obstetrics 2/2011 Zur Ausgabe

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

15.05.2024 Mammakarzinom Nachrichten

Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Embryotransfer erhöht womöglich Leukämierisiko der Kinder

13.05.2024 Assistierte Reproduktion Nachrichten

Reproduktionsmedizinische Techniken haben theoretisch das Potenzial, den epigenetischen Code zu verändern und somit das Krebsrisiko der Kinder zu erhöhen. Zwischen Embryotransfer und Leukämie scheint sich ein solcher Zusammenhang bestätigt zu haben.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.