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Erschienen in:

01.12.2011 | Materno-fetal Medicine

Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin

verfasst von: Francesca Riboni, Anna Vitulo, Marinella Dell’avanzo, Mario Plebani, Giuseppe Battagliarin, Delia Paternoster

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2011

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Abstract

Purpose

The aim of this study was to evaluate the efficacy of the phosphorylated insulin-like growth factor-binding protein (phIGFBP-1) and of the fetal fibronectin test (fFN) in predicting pre-term delivery in symptomatic women.

Methods

We included 210 symptomatic women at 24–34 weeks’ gestation, who underwent the phIGFBP-1 and fFN test. We analyzed the prevalence of pre-term delivery in these patients within 7 days upon admission, before the 34th and the 37th weeks’ gestation.

Results

The 3.8% of women delivered within 7 days upon the admission, the 7.6% before 34 weeks and the 16.2% before 37 weeks’ gestation. The phIGFBP-1 and fFN test had a high specificity and a high negative predictive value in predicting pre-term delivery within 7 days, before 34 and before 37 weeks’ gestation. The logistic regression of phIGFBP-1 was statistically significant in predicting pre-term delivery with an odds ratio of 10.08 <34 weeks’ gestation. The multivariate analysis showed that the phIGFBP test had a higher OR <34 weeks’ gestation (p < 0.001) and that the two variables were independent and useful in combination to predict pre-term delivery (<37 weeks’ gestation).

Conclusion

The phIGFBP-1 test may be better that the fFN test in predicting pre-term delivery before 34 weeks’ gestation.

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Titel: Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin
verfasst von: Francesca Riboni
Anna Vitulo
Marinella Dell’avanzo
Mario Plebani
Giuseppe Battagliarin
Delia Paternoster
Publikationsdatum: 01.12.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-011-1839-4

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Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin-like growth factor binding protein-1 and fetal fibronectin