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Archives of Gynecology and Obstetrics

Erschienen in:

01.07.2012 | General Gynecology

Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis

verfasst von: Shoujun Liang, Yin Huang, Yujuan Fan

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2012

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Abstract

Purpose

The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.

Methods

By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.

Result

An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027–1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024–1.375, P = 0.023. Random-effcet model: TT + TC vs. CC: OR 1.203, 95% CI 1.003–1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021–1.382, P = 0.026). No association between VEGF genes −460CT, +405CG, −2578AC, −1154GA polymorphisms and endometriosis was observed.

Conclusion

Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not −460CT, +405CG, −2578AC, −1154GA.

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Titel: Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis
verfasst von: Shoujun Liang
Yin Huang
Yujuan Fan
Publikationsdatum: 01.07.2012
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2012
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-012-2270-1

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