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16.09.2019 | Gynecologic Endocrinology and Reproductive Medicine

Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen–thawed embryo transfer: a 6-year population-based retrospective study

verfasst von: Bin Li, Yiwen Zhou, Zhiguang Yan, Menghui Li, Songguo Xue, Renfei Cai, Yonglun Fu, Qingqing Hong, Hui Long, Mingru Yin, Tong Du, Yun Wang, Yanping Kuang, Zheng Yan, Qifeng Lyu

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 4/2019

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Abstract

Purpose

To evaluate the impact of artificial oocyte activation (AOA) in pregnancy and neonatal outcomes in infertile patients undergoing cryopreserved embryo transfer.

Method

This retrospective study included 5686 patients’ transferred embryos from routine intracytoplasmic sperm injection (ICSI) and 194 patients’ transferred embryos from ICSI combined with AOA (ICSI-AOA) from January 2011 to December 2016. Pregnancy and neonatal outcomes of couples undergoing routine ICSI or ICSI-AOA were analyzed before and after propensity score matching. Artificial oocyte activation was performed with ionomycin.

Results

The pregnancy outcomes showed no significant difference in the rates of biochemical pregnancy, clinical pregnancy, implantation, miscarriage, ectopic pregnancy, multiple pregnancy, and live births between the routine ICSI and ICSI-AOA groups before and after propensity score matching, respectively. The assessment of neonatal outcomes showed no statistically significant differences in the birth defect rate, birth weight, gestational age, preterm birth rate, early-neonatal death rate, and fetal sex ratio between the two groups, and similar results were also observed in the two matched cohorts.

Conclusion

Artificial oocyte activation with ionomycin does not adversely affect pregnancy and neonatal outcomes in patients undergoing frozen–thawed embryo transfer, which is beneficial to clinicians counseling patients on the risks of artificial oocyte activation.

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Titel: Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen–thawed embryo transfer: a 6-year population-based retrospective study
verfasst von: Bin Li
Yiwen Zhou
Zhiguang Yan
Menghui Li
Songguo Xue
Renfei Cai
Yonglun Fu
Qingqing Hong
Hui Long
Mingru Yin
Tong Du
Yun Wang
Yanping Kuang
Zheng Yan
Qifeng Lyu
Publikationsdatum: 16.09.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 4/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05298-3

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Pregnancy and neonatal outcomes of artificial oocyte activation in patients undergoing frozen–thawed embryo transfer: a 6-year population-based retrospective study