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European Archives of Oto-Rhino-Laryngology

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01.07.2010 | Rhinology

Olfactory and gustatory function in irritable bowel syndrome

verfasst von: Silke Steinbach, Wolfgang Reindl, Claudia Kessel, Roland Ott, Thomas Zahnert, Walter Hundt, Petra Heinrich, Dieter Saur, Wolfgang Huber

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 7/2010

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Abstract

Irritable bowel syndrome (IBS) is the most common, functional disorder diagnosed by gastroenterologists. It is still unclear whether IBS has a central etiology, e.g., hyperreactivity of the brain, or a peripheral etiology, e.g., stimulation of olfactory/gustatory receptors on enterochromaffin cells, followed by serotonin release and changed gut motility. Testing the odor identification (ID), odor discrimination (DIS) and odor threshold (THR) as well as the total taste and the taste qualities “sweet”, “sour”, “salty” and “bitter” should be of help for determining the etiology. To our knowledge, this is the first study investigating the olfactory/gustatory function in IBS patients. The olfactory/gustatory function of 43 patients (32 women, 11 men) suffering from IBS as defined by the ROME III criteria was investigated by means of validated tests (Sniffin’ Sticks and taste strips). Compared to normative data, scores of THR were decreased and scores of ID and DIS were increased in IBS patients. Additionally, when compared to normative data, there was no difference in the taste function of IBS patients. Assuming that THR reflects more the peripheral olfactory function, whereas ID and DIS are influenced by central activity, and that taste did not differ in IBS patients compared to normative data, this supports the idea of a central etiology of IBS.

El-Serag HB (2003) Impact of irritable bowel syndrome: prevalence and effect on health-related quality of life. Rev Gastroenterol Disord 3(Suppl 2):S3–S11PubMed

Wigington WC, Johnson WD, Minocha A (2005) Epidemiology of irritable bowel syndrome among African Americans as compared with whites: a population-based study. Clin Gastroenterol Hepatol 3:647–653CrossRefPubMed

Minocha A, Johnson WD, Abell TL, Wigington WC (2006) Prevalence, sociodemography, and quality of life of older versus younger patients with irritable bowel syndrome: a population-based study. Dig Dis Sci 51:446–453CrossRefPubMed

Drossman DA, Dumitrascu DL (2006) Rome III: new standard for functional gastrointestinal disorders. J Gastrointest Liver Dis 15:237–241

Braun T, Voland P, Kunz L, Prinz C, Gratzl M (2007) Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 132:1890–1901CrossRefPubMed

Kidd M, Modlin IM, Gustafsson BI, Drozdov I, Hauso O, Pfragner R (2008) Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastans, and olfactions. Am J Physiol Gastrointest Liver Physiol 295:G260–G272CrossRefPubMed

Mertz H, Morgan V, Tanner G, Pickens D, Price R, Shyr Y, Kessler R (2000) Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distension. Gastroenterology 118:842–848CrossRefPubMed

Naliboff BD, Derbyshire SW, Munakata J, Berman S, Mandelkern M, Chang L, Mayer EA (2001) Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation. Psychosom Med 63:365–375PubMed

Verne GN, Himes NC, Robinson ME, Gopinath KS, Briggs RW, Crosson B, Price DD (2003) Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome. Pain 103:99–110CrossRefPubMed

10.

Mayer EA, Berman S, Suyenobu B, Labus J, Mandelkern MA, Naliboff BD, Chang L (2005) Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis. Pain 115:398–409CrossRefPubMed

11.

Bernstein CN, Frankenstein UN, Rawsthorne P, Pitz M, Summers R, McIntyre MC (2002) Cortical mapping of visceral pain in patients with GI disorders using functional magnetic resonance imaging. Am J Gastroenterol 97:319–327CrossRefPubMed

12.

Ringel Y, Drossman DA, Turkington TG, Bradshaw B, Hawk TC, Bangdiwala S, Coleman RE, Whitehead WE (2003) Regional brain activation in response to rectal distensions in patients with irritable bowel syndrome and the effect of a history of abuse. Dig Dis Sci 48:1774–1781CrossRefPubMed

13.

Wilder-Smith CH, Schindler D, Lovblad K, Redmond SM, Nirkko A (2004) Brain functional magnetic resonance imaging of rectal pain and activation of endogenous inhibitory mechanisms in irritable bowel syndrome patient subgroups and healthy controls. Gut 53:1595–1601CrossRefPubMed

14.

Andresen V, Bach DR, Poellinger A, Tsrouya C, Stroh A, Foerschler A, Georgiewa P, Zimmer C, Mönnikes H (2005) Brain activation responses to subliminal or supraliminal rectal stimuli and to auditory stimuli in irritable bowel syndrome. Neurogastroenterol Motil 17:827–837CrossRefPubMed

15.

Kwan CL, Diamant NE, Pope G, Mikula K, Mikulis DJ, Davis KD (2005) Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurology 65:1268–1277CrossRefPubMed

16.

Kobal G, Hummel T, Sekinger B, Barz S, Roscher S, Wolf S (1996) “Sniffin sticks”: screening of olfactory performance. Rhinology 34:222–226PubMed

17.

Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) ‘Sniffin’ sticks’: olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39–52CrossRefPubMed

18.

Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243CrossRefPubMed

19.

Mueller C, Kallert S, Renner B, Stiassny K, Temmel AF, Hummel T, Kobal G (2003) Quantitative assessment of gustatory function in a clinical context using impregnated “taste strips”. Rhinology 41:2–6PubMed

20.

Kroenke K, Spitzer RL, Williams JB (2002) The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med 64:258–266PubMed

21.

Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K (2004) Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care 42:1194–1201CrossRefPubMed

22.

Löwe B, Decker O, Müller S, Brähler E, Schellberg D, Herzog W, Herzberg PY (2008) Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Med Care 46:266–274CrossRefPubMed

23.

Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L (1984) Smell identification ability: changes with age. Science 226:1441–1443CrossRefPubMed

24.

Rawson NE (2006) Olfactory loss in aging. Sci Aging Knowl Environ 5:6

25.

Stevens JC, Bartoshuk LM, Cain WS (1984) Chemical senses and aging: taste versus smell. Chem Senses 9:167–179CrossRef

26.

Cowart BJ (1989) Relationships between taste across the adult life span. Ann NY Acad Sci 561:39–55CrossRefPubMed

27.

Stevens JC, Cain WS (1993) Changes in taste and flavour in aging. Crit Rev Food Sci Nutr 33:27–37CrossRefPubMed

28.

Nordin S, Brämerson A, Bringlöv E, Kobal G, Hummel T, Bende M (2007) Substance and tongue-region specific loss in basic taste-quality identification in elderly adults. Eur Arch Otorhinolaryngol 264:285–289CrossRefPubMed

29.

Simchen U, Koebnick C, Hoyer S, Issanchou S, Zunft HJ (2006) Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight. Eur J Clin Nutr 60:698–705CrossRefPubMed

30.

Richardson BE, Vander Woude EA, Sudan R, Thompson JS, Leopold DA (2004) Altered olfactory acuity in the morbidly obese. Obes Surg 14:967–969CrossRefPubMed

31.

Whitehead WE, Palsson O, Jones KR (2002) Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology 122:1140–1156CrossRefPubMed

32.

Porcelli P (2004) Psychological abnormalities in patients with irritable bowel syndrome. Indian J Gastroenterol 23:63–69PubMed

33.

Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114:1764–1769CrossRefPubMed

34.

Pentzek M, Grass-Kapanke B, Ihl R (2007) Odor identification in Alzheimers disease and depression. Aging Clin Exp Res 19:255–258PubMed

35.

Pause BM, Miranda A, Göder R, Aldenhoff JB, Ferstl R (2001) Reduced olfactory performance in patients with major depression. J Psychiatr Res 35:271–277CrossRefPubMed

36.

Pollatos O, Albrecht J, Kopietz R, Linn J, Schoepf V, Kleemann AM, Schreder T, Schandry R, Wiesmann M (2007) Reduced olfactory sensitivity in subjects with depressive symptoms. J Affect Disord 102:101–108CrossRefPubMed

37.

Jones-Gotman M, Zatorre RJ (1988) Olfactory identification deficits in patients with focal cerebral excision. Neuropsychologia 26:387–400CrossRefPubMed

38.

Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL (1999) Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21:325–340CrossRefPubMed

39.

Van Oudenhave L, Coen SJ, Aziz Q (2007) Functional brain imaging of gastrointestinal sensation in health and disease. World J Gastroenterol 13:3438–3445

40.

Blomhoff S, Jacobsen MB, Spetalen S, Dahm A, Malt UF (2000) Perceptual hyperreactivity to auditory stimuli in patients with irritable bowel syndrome. Scand J Gastroenterol 35:583–589CrossRefPubMed

41.

Berman SM, Naliboff BD, Chang L, Fitzgerald L, Antolin T, Camplone A, Mayer EA (2002) Enhanced preattentive central nervous system reactivity in irritable bowel syndrome. Am J Gastroenterol 97:2791–2797CrossRefPubMed

42.

Andresen V, Poellinger A, Tsrouya C, Bach D, Stroh A, Foerschler A, Georgiewa P, Schmidtmann M, van der Voort IR, Kobelt P, Zimmer C, Wiedenmann B, Klapp BF, Monnikes H (2006) Cerebral processing of auditory stimuli in patients with irritable bowel syndrome. World J Gastroenterol 12:1723–1729PubMed

Titel: Olfactory and gustatory function in irritable bowel syndrome
verfasst von: Silke Steinbach
Wolfgang Reindl
Claudia Kessel
Roland Ott
Thomas Zahnert
Walter Hundt
Petra Heinrich
Dieter Saur
Wolfgang Huber
Publikationsdatum: 01.07.2010
Verlag: Springer-Verlag
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 7/2010
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-009-1181-7

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Olfactory and gustatory function in irritable bowel syndrome

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