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01.02.2014

Cough in Asthma Is due to Eosinophilic Airway Inflammation: A Pro/Con Debate

verfasst von: Akio Niimi, Christopher E. Brightling, Peter V. Dicpinigaitis

Erschienen in: Lung | Ausgabe 1/2014

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Abstract

Multiple prospective studies have demonstrated that asthma is among the most common etiologies of chronic cough, along with upper-airway cough syndrome (formerly known as postnasal drip syndrome) and gastroesophageal reflux disease. More recently, the entity of nonasthmatic eosinophilic bronchitis has been appreciated as a significant cause of chronic cough worldwide. Chronic cough associated with both of these conditions typically responds well to therapy with systemic or inhaled corticosteroids, thus leading to a general assumption that the suppression of eosinophilic airway inflammation explains the improvement in cough. However, some recent studies challenge a causal relationship between eosinophilic airway inflammation and cough in asthmatics. The 4th American Cough Conference, held in New York in June 2013, provided an ideal forum for discussion and debate of this issue between two internationally recognized experts in the field of asthma and chronic cough.

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Dicpinigaitis PV (2006) Chronic cough due to asthma: ACCP evidence-based clinical practice guidelines. Chest 129(1 Suppl):75S–79SCrossRefPubMed

Brightling CE, Ward R, Goh KL et al (1999) Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 160:406–410CrossRefPubMed

Corrao WM, Braman SS, Irwin RS (1979) Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med 300:633–637CrossRefPubMed

Pavord ID, Brightling CE, Woltmann G et al (1999) Non-eosinophilic corticosteroid unresponsive asthma. Lancet 353:2213–2214CrossRefPubMed

McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM et al (2012) Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. A large subgroup of mild-to-moderate asthma is persistently non-eosinophilic. Am J Respir Crit Care Med 185:612–619PubMedCentralCrossRefPubMed

Gibson PG, Dolovich J, Denburg J et al (1989) Chronic cough: eosinophilic bronchitis without asthma. Lancet 1:1346–1348CrossRefPubMed

McGarvey LP, Heaney LG, Lawson JT et al (1998) Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. Thorax 53:738–743PubMedCentralCrossRefPubMed

Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F (1998) Eosinophilic inflammation in cough variant asthma. Eur Respir J 11:1064–1069CrossRefPubMed

Matsumoto H, Niimi A, Takemura M, Ueda T, Yamaguchi M, Matsuoka H et al (2009) Features of cough variant asthma and classic asthma during methacholine-induced bronchoconstriction: a cross-sectional study. Cough 5:3PubMedCentralCrossRefPubMed

10.

Takemura M, Niimi A, Matsumoto H, Ueda T, Yamaguchi M, Matsuoka H et al (2007) Atopic features of cough variant asthma and classic asthma with wheezing. Clin Exp Allergy 37:1833–1839CrossRefPubMed

11.

Otsuka K, Niimi A, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H et al (2011) Plasma substance P levels in patients with persistent cough. Respiration 82:431–438CrossRefPubMed

12.

Brightling CE, Ward R, Wardlaw AJ, Pavord ID (2000) Airway inflammation, airway responsiveness and cough before and after inhaled budesonide in patients with eosinophilic bronchitis. Eur Respir J 15:682–686CrossRefPubMed

13.

Weinstock JV, Blum A, Walder J, Walder R (1988) Eosinophils from granulomas in murine Schistosomiasis mansoni produce substance P. J Immunol 141:961–966PubMed

14.

Lee SY, Kim MK, Shin C, Shim JJ, Kim HK, Kang KH et al (2003) Substance P-immmunoreactive nerves in endobronchial biopsies in cough-variant asthma and classsic asthma. Respiration 70:49–53CrossRefPubMed

15.

Niimi A, Matsumoto H, Minakuchi M, Kitaichi M, Amitani R et al (2000) Airway remodelling in cough-variant asthma. Lancet 356:564–565CrossRefPubMed

16.

Niimi A, Torrego A, Nicholson AG, Cosio BG, Oates TB, Chung KF (2005) Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol 116:565–570CrossRefPubMed

17.

Matsumoto H, Niimi A, Tabuena RP, Takemura M, Ueda T, Yamaguchi M et al (2007) Airway wall thickening in patients with cough variant asthma and nonasthmatic chronic cough. Chest 131:1042–1049CrossRefPubMed

18.

Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE et al (2004) A critical role for eosinophils in allergic airways remodeling. Science 305:1776–1779CrossRefPubMed

19.

Beasley R, Roche WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139:806–817CrossRefPubMed

20.

Niimi A (2011) Structural changes in the airways: cause or effect of chronic cough? Pulm Pharmacol Ther 24:328–333CrossRefPubMed

21.

Matsuoka H, Niimi A, Matsumoto H et al (2010) Inflammatory subtypes in cough variant asthma: association with maintenance doses of inhaled corticosteroids. Chest 138:1418–1425CrossRefPubMed

22.

Simpson JL, Scott R, Boyle MJ, Gibson PG (2006) Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 11:54–61CrossRefPubMed

23.

Page SM, Gleich GJ, Roebuck KA, Thomas LL (1999) Stimulation of neutrophil interleukin-8 production by eosinophil granule major basic protein. Am J Respir Cell Mol Biol 21:230–237CrossRefPubMed

24.

Brightling CE, Bradding P, Symon FA et al (2002) Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med 346:1699–1705CrossRefPubMed

25.

McGarvey LPA, Forsythe P, Heaney LG, MacMahon J, Ennis M (1999) Bronchoalveolar lavage findings in patients with chronic nonproductive cough. Eur Respir J 13:59–65CrossRefPubMed

26.

Birring SS, Parker D, Brightling CE, Bradding P, Wardlaw AJ, Pavord ID (2004) Induced sputum inflammatory mediator concentrations in chronic cough. Am J Respir Crit Care Med 169:15–19CrossRefPubMed

27.

Gibson PG (2004) Cough is an airway itch? Am J Respir Crit Care Med 169:1–2CrossRefPubMed

28.

Skaper SD, Pollock M, Facci L (2001) Mast cells differentially express and release active high molecular weight neurotrophins. Brain Res Mol Brain Res 97:177–185CrossRefPubMed

29.

O’Connell F, Springall DR, Moradoghli-Haftvani A, Krausz T, Price D, Fuller RW et al (1995) Abnormal intraepithelial airway nerves in persistent unexplained cough? Am J Respir Crit Care Med 152:2068–2075CrossRefPubMed

30.

Repke H, Piotrowski W, Bienert M, Foreman JC (1987) Histamine release induced by Arg-Pro-Lys-Pro(CH2)11CH3 from rat peritoneal mast cells. J Pharmacol Exp Ther 243:317–321PubMed

31.

Costello RW, Schofield BH, Kephart GM, Gleich GJ, Jacoby DB, Fryer AD (1997) Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol 273:L93–L103PubMed

32.

Kingham PJ, Costello RW, McLean WG (2003) Eosinophil and airway nerve interactions. Pulm Pharmacol Ther 16:9–13CrossRefPubMed

33.

Lee LY, Gu Q, Gleich GJ (2001) Effects of human eosinophil granule-derived cationic proteins on C-fiber afferents in the rat lung. J Appl Physiol 91:1318–1326PubMed

34.

Garland A, Necheles J, White SR, Neeley SP, Leff AR, Carson SS et al (1997) Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. Am J Physiol 273:L1096–L1102PubMed

35.

Numao T, Agrawal DK (1992) Neuropeptides modulate human eosinophil chemotaxis. J Immunol 149:3309–3315PubMed

36.

Piliponsky AM, Gleich GJ, Nagler A, Bar I, Levi-Schaffer F (2003) Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood 101:1898–1904CrossRefPubMed

37.

Adelroth E, Rosenhall L, Johansson SA, Linden M, Venge P (1990) Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline. Am Rev Respir Dis 142:91–99CrossRefPubMed

38.

Djukanović R, Wilson JW, Britten KM, Wilson SJ, Walls AF, Roche WR et al (1992) Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 145:669–674CrossRefPubMed

39.

Gibson PG, Saltos N, Fakes K (2001) Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial. Am J Respir Crit Care Med 163:32–36CrossRefPubMed

40.

Lemiere C, Efthimiadis A, Hargreave FE (1997) Occupational eosinophilic bronchitis without asthma: an unknown occupational airway disease. J Allergy Clin Immunol 100:852–853CrossRefPubMed

41.

Gibson PG, Hargreave FE, Girgis-Gabardo A et al (1995) Chronic cough with eosinophilic bronchitis: examination for variable airflow obstruction and response to corticosteroid. Clin Exp Allergy 25:127–132CrossRefPubMed

42.

Carney IK, Gibson PG, Murree-Allen K et al (1997) A systematic evaluation of mechanisms in chronic cough. Am J Respir Crit Care Med 156:211–216CrossRefPubMed

43.

Brightling CE, Monteiro W, Ward R et al (2000) Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 356:1480–1485CrossRefPubMed

44.

Pizzichini MM, Pizzichini E, Parameswaran K et al (1999) Nonasthmatic chronic cough: no effect of treatment with an inhaled corticosteroid in patients without sputum eosinophilia. Can Respir J 6:323–330PubMed

45.

Wardlaw AJ (1999) Molecular basis for selective eosinophil trafficking in asthma: a multistep paradigm. J Allergy Clin Immunol 104:917–926CrossRefPubMed

46.

Leckie MJ, ten Brinke A, Khan J, Diamant Z, O’Connor BJ, Walls CM et al (2000) Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356:2144–2148CrossRefPubMed

47.

Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS (2003) Eosinophil’s role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 167:199–204CrossRefPubMed

48.

Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A et al (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360:973–984PubMedCentralCrossRefPubMed

49.

Brightling CE, Symon FA, Birring SS et al (2003) Comparison of the immunopathology of eosinophilic bronchitis and asthma. Thorax 58:528–532PubMedCentralCrossRefPubMed

50.

Brightling CE, Ward R, Woltmann G et al (2000) Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med 162:878–882CrossRefPubMed

51.

Gibson PG, Zlatic K, Scott J et al (1998) Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. J Allergy Clin Immunol 101:320–326CrossRefPubMed

52.

Hermine O, Lortholary O, Leventhal PS, Catteau A, Soppelsa F, Baude C et al (2008) Case-controlled cohort study of patients’ perceptions of disability in mastocytosis. PLoS One 3:e2266PubMedCentralCrossRefPubMed

53.

Djukanović R, Homeyard S, Gratziou C, Madden J, Walls A, Montefort S et al (1997) The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation. Am J Respir Crit Care Med 155:826–832CrossRefPubMed

54.

Chung KF, Hew M, Score J, Jones AV, Reiter A, Cross NC et al (2006) Cough and hypereosinophilia due to FIP1L1-PDGFRA fusion gene with tyrosine kinase activity. Eur Respir J 27:230–232CrossRefPubMed

55.

Barker B, Moudgil H, Slocombe G, Srinivasan K (2010) Persistent cough: an unusual cause. Idiopathic hypereosinophilic syndrome (HES). Thorax 65:1009CrossRefPubMed

Titel: Cough in Asthma Is due to Eosinophilic Airway Inflammation: A Pro/Con Debate
verfasst von: Akio Niimi
Christopher E. Brightling
Peter V. Dicpinigaitis
Publikationsdatum: 01.02.2014
Verlag: Springer US
Erschienen in: Lung / Ausgabe 1/2014
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-013-9543-8

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