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01.06.2014

Prognostic Value of Central Venous Oxygen Saturation and Blood Lactate Levels Measured Simultaneously in the Same Patients with Severe Systemic Inflammatory Response Syndrome and Severe Sepsis

verfasst von: Ju-Hee Park, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Young Whan Kim, Sung Koo Han, Chul-Gyu Yoo

Erschienen in: Lung | Ausgabe 3/2014

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Abstract

Background

Blood lactate levels and central venous oxygen saturation (ScvO₂) are known to be useful indicators of global tissue hypoxia. However, it is unclear whether ScvO₂ correlates with lactate levels when measured simultaneously and whether changes in ScvO₂ or lactate levels in serial measurements have prognostic value. We investigated the correlation between ScvO₂ and lactate levels measured simultaneously and their association with clinical outcomes.

Methods

We performed a prospective observational study of patients with severe systemic inflammatory response syndrome (SIRS) and severe sepsis who were admitted to the medical intensive care unit. ScvO₂ and lactate levels were measured simultaneously at the time of study enrollment, every 6 h for 24 h, and then every 24 h until the goal was reached.

Results

Twenty-five patients were enrolled in the study; 13 have died and 12 have survived. There was no correlation between lactate levels and ScvO₂. Neither lactate levels nor ScvO₂ at the time of admission differed between nonsurvivors and survivors. Normalization of lactate levels within 48 h was significantly associated with survival.

Conclusions

In patients with severe SIRS and severe sepsis, simultaneously measured ScvO₂ and lactate levels showed no correlation, and normalization of lactate levels within 48 h was a predictive factor for survival.

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Titel: Prognostic Value of Central Venous Oxygen Saturation and Blood Lactate Levels Measured Simultaneously in the Same Patients with Severe Systemic Inflammatory Response Syndrome and Severe Sepsis
verfasst von: Ju-Hee Park
Jinwoo Lee
Young Sik Park
Chang-Hoon Lee
Sang-Min Lee
Jae-Joon Yim
Young Whan Kim
Sung Koo Han
Chul-Gyu Yoo
Publikationsdatum: 01.06.2014
Verlag: Springer US
Erschienen in: Lung / Ausgabe 3/2014
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI: https://doi.org/10.1007/s00408-014-9564-y

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