Skip to main content
Erschienen in: Journal of Neurology 11/2009

01.11.2009 | Letter to the editors

Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes

verfasst von: Sarah H. Ying, Bennett A. Landman, Shwetadwip Chowdhury, Alexander H. Sinofsky, Anna Gambini, Susumu Mori, David S. Zee, Jerry L. Prince

Erschienen in: Journal of Neurology | Ausgabe 11/2009

Einloggen, um Zugang zu erhalten

Abstract

The cerebellar peduncles are excellent candidates for composite indicators of regional degeneration in posterior fossa structures, as the peduncles show histopathological changes in degenerative ataxia. We postulate that magnetic resonance imaging will reveal evidence of disease specific peduncle degeneration through macrostructural (cross-sectional area) and microstructural (fractional anisotropy, mean diffusivity) measures. This study presents a “proof of principle” using orthogonal diffusion tensor imaging cross-sections of the cerebellar peduncles to distinguish categories of cerebellar disease.
Literatur
1.
Zurück zum Zitat Berciano J, Boesch S, Perez-Ramos JM, Wenning GK (2006) Olivopontocerebellar atrophy: toward a better nosological definition. Mov Disord 21:1607–1613CrossRefPubMed Berciano J, Boesch S, Perez-Ramos JM, Wenning GK (2006) Olivopontocerebellar atrophy: toward a better nosological definition. Mov Disord 21:1607–1613CrossRefPubMed
2.
Zurück zum Zitat Landman BA, Chowdhury S, Sinofsky AH, Liu ASK, Mori S, Zee DS, Prince JL, Ying SH (2006) Delineation of cerebellar fiber tracts on anatomically aligned planes with ViPAR, a novel MRI visualization and manipulation tool. Organization for Human Brain Mapping, Florence Landman BA, Chowdhury S, Sinofsky AH, Liu ASK, Mori S, Zee DS, Prince JL, Ying SH (2006) Delineation of cerebellar fiber tracts on anatomically aligned planes with ViPAR, a novel MRI visualization and manipulation tool. Organization for Human Brain Mapping, Florence
3.
Zurück zum Zitat McAuliffe MJ, Lalonde F, McGarry DP, Gandler W, Csaky K, Trus BL (2001). Medical image processing, analysis and visualization in clinical research. In: Proceedings of the 14th IEEE symposium on computer-based medical systems (CBMS 2001) McAuliffe MJ, Lalonde F, McGarry DP, Gandler W, Csaky K, Trus BL (2001). Medical image processing, analysis and visualization in clinical research. In: Proceedings of the 14th IEEE symposium on computer-based medical systems (CBMS 2001)
4.
Zurück zum Zitat Mandelli ML, De ST, Minati L, Bruzzone MG, Mariotti C, Fancellu R, Savoiardo M, Grisoli M (2007) Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2. Am J Neuroradiol 28:1996–2000CrossRefPubMed Mandelli ML, De ST, Minati L, Bruzzone MG, Mariotti C, Fancellu R, Savoiardo M, Grisoli M (2007) Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2. Am J Neuroradiol 28:1996–2000CrossRefPubMed
5.
Zurück zum Zitat Shiga K, Yamada K, Yoshikawa K, Mizuno T, Nishimura T, Nakagawa M (2005) Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy. J Neurol 252:589–596CrossRefPubMed Shiga K, Yamada K, Yoshikawa K, Mizuno T, Nishimura T, Nakagawa M (2005) Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy. J Neurol 252:589–596CrossRefPubMed
6.
Zurück zum Zitat Murata Y, Kawakami H, Yamaguchi S, Nishimura M, Kohriyama T, Ishizaki F, Matsuyama Z, Mimori Y, Nakamura S (1998) Characteristic magnetic resonance imaging findings in spinocerebellar ataxia 6. Arch Neurol 55:1348–1352CrossRefPubMed Murata Y, Kawakami H, Yamaguchi S, Nishimura M, Kohriyama T, Ishizaki F, Matsuyama Z, Mimori Y, Nakamura S (1998) Characteristic magnetic resonance imaging findings in spinocerebellar ataxia 6. Arch Neurol 55:1348–1352CrossRefPubMed
Metadaten
Titel
Orthogonal diffusion-weighted MRI measures distinguish region-specific degeneration in cerebellar ataxia subtypes
verfasst von
Sarah H. Ying
Bennett A. Landman
Shwetadwip Chowdhury
Alexander H. Sinofsky
Anna Gambini
Susumu Mori
David S. Zee
Jerry L. Prince
Publikationsdatum
01.11.2009
Verlag
Springer-Verlag
Erschienen in
Journal of Neurology / Ausgabe 11/2009
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-009-5269-1

Weitere Artikel der Ausgabe 11/2009

Journal of Neurology 11/2009 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.