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Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 5/2015

01.05.2015 | Retinal Disorders

Long-term effectiveness of vitrectomy in diabetic cystoid macular edema

verfasst von: Javier Navarrete-Sanchis, Julian Zarco-Bosquets, Juan Miguel Tomas-Torrent, Teresa Diago, Leticia Ortega-Evangelio

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 5/2015

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Abstract

Background

The aim of this study is to assess whether the outcome of pars plana vitrectomy for the treatment of cystoid non-tractional diabetic macular edema is stable and durable.

Methods

A prospective longitudinal analysis of central macular thickness and visual acuity was performed, using repeated-measures ANOVA, in 22 subjects with cystoid diabetic macular edema.

Results

Of the patients, 45.5 % met the criteria for surgical success at 6 months (achieving a reduction of central macular thickness of over 20 %, without associated loss of vision and central macular thickness less than 300 μm), of which 70 % remained stable at 1 year. A significant outcome of the intervention was found on central macular thickness (p < 0.01), but not on visual acuity (p = 0.159). This change occurred in the immediate postoperative period to remain stable thereafter.

Conclusions

Vitreoretinal surgery can be an alternative treatment option in cases that do not respond to other types of treatment provided. Its expected benefit is observed in most cases in the immediate postoperative period, and is usually stable and sustained over 1-year follow-up.
Literatur
1.
Zurück zum Zitat Klein R, Klein BE, Moss SE, Davis MD, DeMets DL (1984) The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema. Ophthalmology 91(12):1464–1474CrossRefPubMed Klein R, Klein BE, Moss SE, Davis MD, DeMets DL (1984) The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema. Ophthalmology 91(12):1464–1474CrossRefPubMed
2.
Zurück zum Zitat Sander B, Larsen M, Moldow B, Lund-Andersen H (2001) Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci 42(2):433–438PubMed Sander B, Larsen M, Moldow B, Lund-Andersen H (2001) Diabetic macular edema: passive and active transport of fluorescein through the blood-retina barrier. Invest Ophthalmol Vis Sci 42(2):433–438PubMed
3.
Zurück zum Zitat Caldwell RB, Slapnick SM, McLaughlin BJ (1985) Lanthanum and freeze-fracture studies of retinal pigment epithelial cell junctions in the streptozotocin diabetic rat. Curr Eye Res 4(3):215–227CrossRefPubMed Caldwell RB, Slapnick SM, McLaughlin BJ (1985) Lanthanum and freeze-fracture studies of retinal pigment epithelial cell junctions in the streptozotocin diabetic rat. Curr Eye Res 4(3):215–227CrossRefPubMed
4.
Zurück zum Zitat Tso MO, Cunha-Vaz JG, Shih CY, Jones CW (1980) Clinicopathologic study of blood-retinal barrier in experimental diabetes mellitus. Arch Ophthalmol 98(11):2032–2040CrossRefPubMed Tso MO, Cunha-Vaz JG, Shih CY, Jones CW (1980) Clinicopathologic study of blood-retinal barrier in experimental diabetes mellitus. Arch Ophthalmol 98(11):2032–2040CrossRefPubMed
5.
Zurück zum Zitat Early Treatment Diabetic Retinopathy Study research group (1985) Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 103(12):1796–1806CrossRef Early Treatment Diabetic Retinopathy Study research group (1985) Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 103(12):1796–1806CrossRef
6.
Zurück zum Zitat Haller JA, Qin H, Apte RS, Beck RR, Bressler NM, Browning DJ, Danis RP, Glassman AR, Googe JM, Kollman C, Lauer AK, Peters MA, Stockman ME (2010) Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology 117(6):1087–1093 e1083CrossRefPubMed Haller JA, Qin H, Apte RS, Beck RR, Bressler NM, Browning DJ, Danis RP, Glassman AR, Googe JM, Kollman C, Lauer AK, Peters MA, Stockman ME (2010) Vitrectomy outcomes in eyes with diabetic macular edema and vitreomacular traction. Ophthalmology 117(6):1087–1093 e1083CrossRefPubMed
7.
Zurück zum Zitat Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY (1993) The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol 111(6):831–836CrossRefPubMed Chylack LT Jr, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, Friend J, McCarthy D, Wu SY (1993) The Lens Opacities Classification System III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol 111(6):831–836CrossRefPubMed
8.
Zurück zum Zitat Ferris FL 3rd, Miller KM, Glassman AR, Beck RW (2010) A proposed method of logarithmic transformation of optical coherence tomography data for use in clinical research. Ophthalmology 117(8):1512–1516CrossRefPubMedCentralPubMed Ferris FL 3rd, Miller KM, Glassman AR, Beck RW (2010) A proposed method of logarithmic transformation of optical coherence tomography data for use in clinical research. Ophthalmology 117(8):1512–1516CrossRefPubMedCentralPubMed
9.
Zurück zum Zitat Raman R, Rani PK, Kulothungan V, Rachepalle SR, Kumaramanickavel G, Sharma T (2010) Influence of serum lipids on clinically significant versus nonclinically significant macular edema: SN-DREAMS Report number 13. Ophthalmology 117(4):766–772CrossRefPubMed Raman R, Rani PK, Kulothungan V, Rachepalle SR, Kumaramanickavel G, Sharma T (2010) Influence of serum lipids on clinically significant versus nonclinically significant macular edema: SN-DREAMS Report number 13. Ophthalmology 117(4):766–772CrossRefPubMed
10.
Zurück zum Zitat Flaxel CJ, Edwards AR, Aiello LP, Arrigg PG, Beck RW, Bressler NM, Bressler SB, Ferris FL 3rd, Gupta SK, Haller JA, Lazarus HS, Qin H (2010) Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema: diabetic retinopathy clinical research network. Retina 30(9):1488–1495CrossRefPubMed Flaxel CJ, Edwards AR, Aiello LP, Arrigg PG, Beck RW, Bressler NM, Bressler SB, Ferris FL 3rd, Gupta SK, Haller JA, Lazarus HS, Qin H (2010) Factors associated with visual acuity outcomes after vitrectomy for diabetic macular edema: diabetic retinopathy clinical research network. Retina 30(9):1488–1495CrossRefPubMed
11.
Zurück zum Zitat Lewis H, Abrams GW, Blumenkranz MS, Campo RV (1992) Vitrectomy for diabetic macular traction and edema associated with posterior hyaloidal traction. Ophthalmology 99(5):753–759CrossRefPubMed Lewis H, Abrams GW, Blumenkranz MS, Campo RV (1992) Vitrectomy for diabetic macular traction and edema associated with posterior hyaloidal traction. Ophthalmology 99(5):753–759CrossRefPubMed
12.
Zurück zum Zitat Harbour JW, Smiddy WE, Flynn HW Jr, Rubsamen PE (1996) Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane. Am J Ophthalmol 121(4):405–413CrossRefPubMed Harbour JW, Smiddy WE, Flynn HW Jr, Rubsamen PE (1996) Vitrectomy for diabetic macular edema associated with a thickened and taut posterior hyaloid membrane. Am J Ophthalmol 121(4):405–413CrossRefPubMed
13.
Zurück zum Zitat Pendergast SD, Hassan TS, Williams GA, Cox MS, Margherio RR, Ferrone PJ, Garretson BR, Trese MT (2000) Vitrectomy for diffuse diabetic macular edema associated with a taut premacular posterior hyaloid. Am J Ophthalmol 130(2):178–186CrossRefPubMed Pendergast SD, Hassan TS, Williams GA, Cox MS, Margherio RR, Ferrone PJ, Garretson BR, Trese MT (2000) Vitrectomy for diffuse diabetic macular edema associated with a taut premacular posterior hyaloid. Am J Ophthalmol 130(2):178–186CrossRefPubMed
14.
Zurück zum Zitat Stolba U, Binder S, Gruber D, Krebs I, Aggermann T, Neumaier B (2005) Vitrectomy for persistent diffuse diabetic macular edema. Am J Ophthalmol 140(2):295–301PubMed Stolba U, Binder S, Gruber D, Krebs I, Aggermann T, Neumaier B (2005) Vitrectomy for persistent diffuse diabetic macular edema. Am J Ophthalmol 140(2):295–301PubMed
15.
Zurück zum Zitat Yanyali A, Nohutcu AF, Horozoglu F, Celik E (2005) Modified grid laser photocoagulation versus pars plana vitrectomy with internal limiting membrane removal in diabetic macular edema. Am J Ophthalmol 139(5):795–801CrossRefPubMed Yanyali A, Nohutcu AF, Horozoglu F, Celik E (2005) Modified grid laser photocoagulation versus pars plana vitrectomy with internal limiting membrane removal in diabetic macular edema. Am J Ophthalmol 139(5):795–801CrossRefPubMed
16.
Zurück zum Zitat Yanyali A, Horozoglu F, Celik E, Nohutcu AF (2007) Long-term outcomes of pars plana vitrectomy with internal limiting membrane removal in diabetic macular edema. Retina 27(5):557–566CrossRefPubMed Yanyali A, Horozoglu F, Celik E, Nohutcu AF (2007) Long-term outcomes of pars plana vitrectomy with internal limiting membrane removal in diabetic macular edema. Retina 27(5):557–566CrossRefPubMed
17.
Zurück zum Zitat Stefansson E, Landers MB 3rd (2006) How does vitrectomy affect diabetic macular edema? Am J Ophthalmol 141(5):984, author reply 984-985CrossRefPubMed Stefansson E, Landers MB 3rd (2006) How does vitrectomy affect diabetic macular edema? Am J Ophthalmol 141(5):984, author reply 984-985CrossRefPubMed
18.
Zurück zum Zitat Nguyen QD, Shah SM, Van Anden E, Sung JU, Vitale S, Campochiaro PA (2004) Supplemental oxygen improves diabetic macular edema: a pilot study. Invest Ophthalmol Vis Sci 45(2):617–624CrossRefPubMed Nguyen QD, Shah SM, Van Anden E, Sung JU, Vitale S, Campochiaro PA (2004) Supplemental oxygen improves diabetic macular edema: a pilot study. Invest Ophthalmol Vis Sci 45(2):617–624CrossRefPubMed
19.
Zurück zum Zitat Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, Ferris FL, 3rd, Friedman SM, Glassman AR, Miller KM, Scott IU, Stockdale CR, Sun JK Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 117 (6):1064-1077 e1035 Elman MJ, Aiello LP, Beck RW, Bressler NM, Bressler SB, Edwards AR, Ferris FL, 3rd, Friedman SM, Glassman AR, Miller KM, Scott IU, Stockdale CR, Sun JK Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology 117 (6):1064-1077 e1035
20.
Zurück zum Zitat Krzystolik MG, Strauber SF, Aiello LP, Beck RW, Berger BB, Bressler NM, Browning DJ, Chambers RB, Danis RP, Davis MD, Glassman AR, Gonzalez VH, Greenberg PB, Gross JG, Kim JE, Kollman C (2007) Reproducibility of macular thickness and volume using Zeiss optical coherence tomography in patients with diabetic macular edema. Ophthalmology 114(8):1520–1525CrossRefPubMed Krzystolik MG, Strauber SF, Aiello LP, Beck RW, Berger BB, Bressler NM, Browning DJ, Chambers RB, Danis RP, Davis MD, Glassman AR, Gonzalez VH, Greenberg PB, Gross JG, Kim JE, Kollman C (2007) Reproducibility of macular thickness and volume using Zeiss optical coherence tomography in patients with diabetic macular edema. Ophthalmology 114(8):1520–1525CrossRefPubMed
21.
Zurück zum Zitat Kimura T, Kiryu J, Nishiwaki H, Oh H, Suzuma K, Watanabe D, Kurimoto M, Takagi H (2005) Efficacy of surgical removal of the internal limiting membrane in diabetic cystoid macular edema. Retina 25(4):454–461CrossRefPubMed Kimura T, Kiryu J, Nishiwaki H, Oh H, Suzuma K, Watanabe D, Kurimoto M, Takagi H (2005) Efficacy of surgical removal of the internal limiting membrane in diabetic cystoid macular edema. Retina 25(4):454–461CrossRefPubMed
22.
Zurück zum Zitat Recchia FM, Ruby AJ, Carvalho Recchia CA (2005) Pars plana vitrectomy with removal of the internal limiting membrane in the treatment of persistent diabetic macular edema. Am J Ophthalmol 139(3):447–454CrossRefPubMed Recchia FM, Ruby AJ, Carvalho Recchia CA (2005) Pars plana vitrectomy with removal of the internal limiting membrane in the treatment of persistent diabetic macular edema. Am J Ophthalmol 139(3):447–454CrossRefPubMed
23.
Zurück zum Zitat Browning DJ, Glassman AR, Aiello LP, Beck RW, Brown DM, Fong DS, Bressler NM, Danis RP, Kinyoun JL, Nguyen QD, Bhavsar AR, Gottlieb J, Pieramici DJ, Rauser ME, Apte RS, Lim JI, Miskala PH (2007) Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology 114(3):525–536CrossRefPubMed Browning DJ, Glassman AR, Aiello LP, Beck RW, Brown DM, Fong DS, Bressler NM, Danis RP, Kinyoun JL, Nguyen QD, Bhavsar AR, Gottlieb J, Pieramici DJ, Rauser ME, Apte RS, Lim JI, Miskala PH (2007) Relationship between optical coherence tomography-measured central retinal thickness and visual acuity in diabetic macular edema. Ophthalmology 114(3):525–536CrossRefPubMed
Metadaten
Titel
Long-term effectiveness of vitrectomy in diabetic cystoid macular edema
verfasst von
Javier Navarrete-Sanchis
Julian Zarco-Bosquets
Juan Miguel Tomas-Torrent
Teresa Diago
Leticia Ortega-Evangelio
Publikationsdatum
01.05.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 5/2015
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-014-2745-9

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