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Graefe's Archive for Clinical and Experimental Ophthalmology

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12.10.2021 | COVID-19 | Retinal Disorders Zur Zeit gratis

Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study

verfasst von: Mojtaba Abrishami, Kiana Hassanpour, SeyedehMaryam Hosseini, Zahra Emamverdian, Mohammad-Reza Ansari-Astaneh, Ghodsieh Zamani, Bahareh Gharib, Majid Abrishami

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 3/2022

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Abstract

Background/aims

To quantify the longitudinal changes of the macular microvasculature and the foveal avascular zone (FAZ) parameters in patients recovered from coronavirus disease-2019 (COVID-19) using optical coherence tomography angiography (OCTA) analysis.

Methods

This observational, longitudinal study was performed on patients recovered from COVID-19. The OCTA images were recorded at baseline and after 1 and 3 months at the follow-up examination. Vessel density (VD) of the retinal superficial (SCP) and deep capillary plexus (DCP), as well as the area of the FAZ of patients who had recovered from COVID-19, were measured.

Results

In total, 36 eyes of 18 patients (62.2% female) with a mean age of 34.5 ± 7.5 years old were included. Regarding SCP, while the VDs of the whole image, fovea, and parafovea were comparable at different time points, the mean VDs in inferior hemifield, as well as superior and inferior regions of perifovea, underwent significant reductions at month 3, compared to the baseline. In DCP, the mean of VD in the whole image was 54.3 ± 2.7 at the first visit which significantly decreased to 52.1 ± 3.8(P = 0.003) and 51.4 ± 2.7(P = 0.001) after 1 and 3 months, respectively. The VDs in all regions of parafovea and perifovea revealed a significant reduction after 1 and 3 months, compared to the first visit. The mean FAZ area was 0.27 ± 0.08 mm², 0.26 ± 0.08 mm², and 0.27 ± 0.08 mm² at the baseline, month 1, and month 3, respectively (P > 0.05).

Conclusion

Based on the results, the patients who had recovered from COVID-19 had a progressive decrease of VD at the follow-up visit 3 months after COVID-19 infection.

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Titel: Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study
verfasst von: Mojtaba Abrishami
Kiana Hassanpour
SeyedehMaryam Hosseini
Zahra Emamverdian
Mohammad-Reza Ansari-Astaneh
Ghodsieh Zamani
Bahareh Gharib
Majid Abrishami
Publikationsdatum: 12.10.2021
Verlag: Springer Berlin Heidelberg
Schlagwort: COVID-19
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 3/2022
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-021-05429-0

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Macular vessel density reduction in patients recovered from COVID-19: a longitudinal optical coherence tomography angiography study

Abstract

Background/aims

Methods

Results

Conclusion

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Background/aims

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