nach oben

Erschienen in:

01.07.2009 | Original Article

Hemodynamic responses to metaboreflex activation: insights from spinal cord-injured humans

verfasst von: Antonio Crisafulli, Raffaele Milia, Stefano Vitelli, Manuela Caddeo, Filippo Tocco, Franco Melis, Alberto Concu

Erschienen in: European Journal of Applied Physiology | Ausgabe 4/2009

Einloggen, um Zugang zu erhalten

Abstract

This investigation was conducted to study the hemodynamic consequences of spinal cord injury (SCI) during post-exercise muscle metaboreflex activation in SCI subjects. The hemodynamic response to metaboreflex recruitment was assessed in ten SCI patients and nine healthy controls (CTL) by means of impedance cardiography. The main results were (1) the metaboreflex-induced blood pressure rise was blunted in SCI subjects compared with normals, (2) the CTL group achieved the blood pressure response via cardiac output increase, while the SCI subjects could not use this mechanism, (3) the CTL group was able to enhance stroke volume and ventricular filling rate in response to the metaboreflex, whereas the SCI group could not. It was concluded that in healthy individuals, the hemodynamic response to the metaboreflex is an integrated phenomenon that depends mainly on a flow-mediated mechanism, whereas in SCI individuals the reduced venous return impairs this mechanism.

Augustyniak RA, Collins HL, Ansorge EJ, Rossi NF, O’Leary DS (2001) Severe exercise alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol (Heart Circ Physiol) 280:H1645–H1652

Bastos BG, Williamson JW, Harrelson T, Nôbrega ACL (2000) Left ventricular volumes and hemodynamic responses to postexercise ischemia in healthy humans. Med Sci Sports Exerc 32:1114–1118PubMedCrossRef

Belardinelli R, Ciampani N, Costantini C, Blandini A, Purcaro A (1996) Comparison of impedance cardiography with thermodilution and direct Fick methods for non-invasive measurement of stroke volume and cardiac output during incremental exercise in patients with ischemic cardiomyopathy. Am J Cardiol 77:1293–1301PubMedCrossRef

Bernstein DP (1986) A new stroke volume equation for thoracic electrical bioimpedance: theory and rationale. Crit Care Med 14:904–909PubMedCrossRef

Crisafulli A, Melis F, Orrù V, Lener R, Lai C, Concu A (2000) Hemodynamics during a postexertional asystolia in a healthy athlete: a case study. Med Sci Sports Exerc 32:4–9PubMedCrossRef

Crisafulli A, Scott AC, Wensel R, Davos CH, Francis DP, Pagliaro P, Coats AJS, Concu A, Piepoli MF (2003a) Muscle metaboreflex-induced increases in stroke volume. Med Sci Sports Exerc 35:221–228PubMedCrossRef

Crisafulli A, Orrù V, Melis F, Tocco F, Concu A (2003b) Hemodynamics during active and passive recovery from a single bout of supramaximal exercise. Eur J Appl Physiol 89:209–216PubMedCrossRef

Crisafulli A, Carta C, Melis F, Tocco F, Frongia F, Santoboni UM, Pagliaro P, Concu A (2004) Hemodynamic responses following intermittent supramaximal exercise in athletes. Exp Physiol 89:665–674PubMedCrossRef

Crisafulli A, Salis E, Pittau G, Lorrai L, Tocco F, Melis F, Pagliaro P, Concu A (2006) Modulation of cardiac contractility by muscle metaboreflex following efforts of different intensities in humans. Am J Physiol (Heart Circ Physiol) 291:H3035–H3042CrossRef

Crisafulli A, Salis E, Tocco F, Melis F, Milia R, Pittau G, Caria MA, Solinas R, Meloni L, Pagliaro P, Concu A (2007) Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients. Am J Physiol (Heart Circ Physiol) 292:2988–2996CrossRef

Crisafulli A, Milia R, Lobina A, Caddeo M, Tocco F, Concu A, Melis F (2008) Hemodynamic effect of metaboreflex activation in men after running above and below the velocity of the anaerobic threshold. Exp Physiol 93:447–457PubMedCrossRef

Davis GM, Servedio GJ, Glaser RM, Gupta SC, Suryaprasad AG (1990) Cardiovascular responses to arm cranking and FNS-induced leg exercise in paraplegics. J Appl Physiol 69:671–677PubMed

Dela F, Mohr T, Jensen CMR, Haahr HL, Secher NH, Biering-Sørensen F, Kjær M (2003) Cardiovascular control during exercise. Insights from spinal cord-injured humans. Circulation 107:2127–2133PubMedCrossRef

Gledhill N, Cox D, Jamnik R (1994) Endurance athletes’ stroke volume does not plateau: major advantage is diastolic function. Med Sci Sports Exerc 26:1116–1121PubMed

Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR (1986) Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circ Res 58:281–291PubMed

Hopman MTE (1994) Circulatory responses during arm exercise in individuals with paraplegia. Int J Sports Med 15:126–131PubMedCrossRef

Iellamo F, Pizzinelli P, Massaro M, Raimondi G, Peruzzi G, Legramante JM (1999) Muscle metaboreflex contribution to sinus node regulation during static exercise. Circulation 100:27–32PubMed

Jacobs PL, Mahoney ET, Robbins A, Nash M (2002) Hypokinetic circulation in persons with paraplegia. Med Sci Sports Exerc 34:1401–1407PubMedCrossRef

Lewis RP, Rittgers SE, Forester WF, Boudoulas A (1977) A critical review of the systolic time intervals. Circulation 56:146–158PubMed

Lewis SF, Taylor WF, Graham RM, Pettinger WA, Schutte JE, Blomqvist CG (1983) Cardiovascular responses to exercise as functions of absolute and relative work load. J Appl Physiol 54:1314–1323PubMedCrossRef

Moran D, Epstein Y, Keren G, Laor A, Sherez J, Shapiro Y (1995) Calculation of mean arterial pressure during exercise as a function of heart rate. Appl Human Sci 14:293–295PubMed

Nishiyasu T, Nobusuke T, Morimoto K, Nishiyasu M, Yamaguchi Y, Murakami N (1994) Enhancement of parasympathetic cardiac activity during activation of muscle metaboreflex in humans. J Appl Physiol 77:2778–2783PubMed

Notarius CF, Atchinson DA, Floras JS (2001) Impact of heart failure and exercise capacity on sympathetic response to handgrip exercise. Am J Physiol (Heart Circ Physiol) 280:H969–H976

O’Leary DS (2006) Altered reflex cardiovascular control during exercise in heart failure: animal studies. Exp Physiol 91:73–77PubMedCrossRef

O’Leary DS, Augustyniak RA (1998) Muscle metaboreflex increases ventricular performance in conscious dogs. Am J Physiol (Heart Circ Physiol) 275:H220–H224

Piepoli M, Clark AL, Coats AJS (1995) Muscle metaboreceptors in hemodynamic, autonomic, and ventilatory responses to exercise in men. Am J Physiol (Heart Circ Phisiol) 269:H1428–H1436

Ponikowski PP, Chua TP, Francis DP, Capucci A, Coats AJS, Piepoli MF (2001) Muscle ergoreceptor overactivity reflects deterioration in the clinical status and cardiorespiratory reflex control in chronic heart failure. Circulation 104:2324–2330PubMedCrossRef

Rowell LB, O’Leary DS (1990) Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes. J Appl Physiol 69:407–418PubMed

Sala-Mercado JA, Hammond RL, Kim JK, Rossi NF, Stephenson LW, O’Leary DS (2006) Muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol (Heart Circ Physiol) 290:H751–H757CrossRef

Sheriff DD, Augstyniak RA, O’Leary DS (1998) Muscle chemoreflex-induced increases in right atrial pressure. Am J Physiol (Heart Circ Physiol) 275:H767–H775

Shoemaker JK, Mattar L, Kerbeci P, Trotter S, Arbeille P, Hughson RL (2007) WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women. J Appl Physiol 103:228–233PubMedCrossRef

Strange S, Secher NH, Pawelczyk JA, Karpakka J, Christensen NJ, Mitchell JH, Saltin B (1993) Neural control of cardiovascular responses and of ventilation during dynamic exercise in man. J Physiol 470:693–704PubMed

Thomas SHL, Crowther A (1993) Impedance cardiography during exercise in patients with coronary heart disease. Eur Heart J 14:150–159PubMed

Warburton DER, Haykowsky MJF, Quinney HA, Humen DP, Teo KK (1999a) Reliability and validity of measures of Cardiac Output during incremental to maximal aerobic exercise. Part I: conventional techniques. Sports Med 27:23–41PubMedCrossRef

Warburton DER, Haykowsky MJF, Quinney HA, Humen DP, Teo KK (1999b) Reliability and validity of measures of cardiac output during incremental to maximal aerobic exercise. Part II: novel techniques and new advances. Sports Med 27:241–260PubMedCrossRef

Titel: Hemodynamic responses to metaboreflex activation: insights from spinal cord-injured humans
verfasst von: Antonio Crisafulli
Raffaele Milia
Stefano Vitelli
Manuela Caddeo
Filippo Tocco
Franco Melis
Alberto Concu
Publikationsdatum: 01.07.2009
Verlag: Springer-Verlag
Erschienen in: European Journal of Applied Physiology / Ausgabe 4/2009
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-009-1045-2

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Open Access ADHS Leitthema

Die Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung (ADHS) ist eine der häufigsten psychischen Störungen im Kindes- und Jugendalter [ 1 ]. In Deutschland beträgt die Prävalenz einer elternberichteten ADHS-Diagnose bei Kindern und Jugendlichen 4,4 % …

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Open Access Leitthema

Die Begrenzung von Schäden durch Substanzkonsum und andere abhängige Verhaltensweisen von Jugendlichen und jungen Erwachsenen ist ein wichtiges Anliegen der öffentlichen Gesundheit. Der Übergang von der Adoleszenz zum jungen Erwachsenenalter ist …

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Leitthema

In der Öffentlichkeit wird die berufliche Ausbildung oftmals unter ökonomischen Gesichtspunkten diskutiert: Mit den geburtenstarken Jahrgängen gehen erfahrene Fachkräfte in Rente und von nachfolgenden Generationen rücken zu wenige Arbeitskräfte …

Rauschtrinken in der frühen Adoleszenz

COVID-19 Leitthema

Alkohol ist in Deutschland die mit Abstand am häufigsten konsumierte psychoaktive Substanz. Mehr als 2 Drittel aller Erwachsenen im Alter von 18 bis 64 Jahren (70,5 %) hat 2021 in den letzten 30 Tagen Alkohol konsumiert [ 1 ]. Von diesen …

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2009

The endothelial microparticle response to a high fat meal is not attenuated by prior exercise

Aerobic high intensity one and two legs interval cycling in chronic obstructive pulmonary disease: the sum of the parts is greater than the whole

Increased distensibility in dependent veins following prolonged bedrest

Assessment of plantar flexors activation capacity: nerve versus muscle stimulation by single versus double pulse

The effects of sildenafil and acetazolamide on breathing efficiency and ventilatory control during hypoxic exercise

Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Rauschtrinken in der frühen Adoleszenz