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Journal of Cancer Research and Clinical Oncology

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01.04.2016 | Original Article – Clinical Oncology

Which is the most suitable lymph node predictor for overall survival after primary surgery of head and neck cancer: pN, the number or the ratio of positive lymph nodes, or log odds?

verfasst von: Mehmet Metin Yildiz, Iver Petersen, Ekkehard Eigendorff, Peter Schlattmann, Orlando Guntinas-Lichius

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 4/2016

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Abstract

Purpose

To investigate the best lymph node (LN) metastasis predictor for overall survival (OS) in head neck cancer (HNC): pN classification, number of positive lymph nodes (PNOD), lymph node ratio (LNR), or log odds of positive lymph nodes (LODDS).

Methods

In total, 225 surgically treated HNC patients were evaluated for the different LN classifications and OS.

Results

Five-year OS was 71.8 %. Mean number of yielded LN and PNOD was 25.3 ± 16.7 and 2.7 ± 5.9, respectively. 64.8 % had a LNR > 0.10 and 64.4 % a LODDS > 10. In univariable analysis, multimodal therapy (p = 0.039), advanced pT (p < 0.0001), advanced UICC stage (p = 0.029), LNR > 0.10 (p = 0.049), and LODDS > −1.0 (p = 0.021) were associated with lower OS. In multivariable analysis, advanced pT [hazard ratio (HR) 2.194; 95 % confidence interval (CI) 1.294–3.722; p = 0.004] and LODDS > −1.0 (HR 1.634; 95 % CI 1.002–2.665; p = 0.059) remained independent predictors for lower OS.

Conclusions

It seems useful to analyze the prognostic significance of LODDS in other samples of HNC.

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Titel: Which is the most suitable lymph node predictor for overall survival after primary surgery of head and neck cancer: pN, the number or the ratio of positive lymph nodes, or log odds?
verfasst von: Mehmet Metin Yildiz
Iver Petersen
Ekkehard Eigendorff
Peter Schlattmann
Orlando Guntinas-Lichius
Publikationsdatum: 01.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 4/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-015-2104-1

Springer Medizin

Which is the most suitable lymph node predictor for overall survival after primary surgery of head and neck cancer: pN, the number or the ratio of positive lymph nodes, or log odds?