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Journal of Cancer Research and Clinical Oncology

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24.10.2016 | Original Article – Clinical Oncology

Left-sided laterality of Merkel cell carcinoma in a German population: more than just sun exposure

verfasst von: T. Gambichler, U. Wieland, S. Silling, M. Dreißigacker, J. Schaller, H.-J. Schulze, F. Oellig, A. Kreuter, M. Stücker, F. G. Bechara, E. Stockfleth, J. C. Becker

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 2/2017

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Abstract

Background

Lateral distribution of cancer has been observed previously. Most evident is this laterality in ultraviolet (UV)-induced skin cancer, based on an unequally distributed UV exposure.

Objectives

The aim of this study was to explore whether patients from Germany also show asymmetrical lateral distribution of Merkel cell carcinoma (MCC).

Methods

In total, 115 patients with MCC were studied for laterality of the primary tumour. Correlation of clinical variables with lateral distribution of MCC was investigated as well.

Results

In 64/115 (55.7%) patients, primary tumours were present on the left side, in 37/115 (32.2%) on the right side, and in 14/115 (12.2%) in the midline (P < 0.0001). Excluding the latter localization occurrence of left-sided MCCs (64 of 101/63.4%) was significantly (P = 0.0072) more often observed (1.73–fold) when compared to right-sided tumours (37 of 101/36.6%). The excess of left-sided tumours was found on the head with a left–right ratio of 1.8, trunk of 8, arm of 1.2, and leg of 1.8. There was no significant association between laterality and gender, age, MCPyV status, and anatomic localization of primary tumours including the occurrence in sun-exposed sites.

Conclusions

Occurrence of left-sided MCCs was significantly more often observed when compared to right-sided tumours. Laterality was not associated with tumour presentation at chronically ultraviolet-exposed sites. Hence, the reason for laterality in MCC remains obscure, but likely goes beyond UV exposure.

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Titel: Left-sided laterality of Merkel cell carcinoma in a German population: more than just sun exposure
verfasst von: T. Gambichler
U. Wieland
S. Silling
M. Dreißigacker
J. Schaller
H.-J. Schulze
F. Oellig
A. Kreuter
M. Stücker
F. G. Bechara
E. Stockfleth
J. C. Becker
Publikationsdatum: 24.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 2/2017
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2293-2

Springer Medizin

Left-sided laterality of Merkel cell carcinoma in a German population: more than just sun exposure