Skip to main content
Erschienen in: Surgical Endoscopy 7/2004

01.07.2004 | Original article

Optimal management of the morbidly obese patient SAGES appropriateness conference statement

verfasst von: D. B. Jones, D. A. Provost, E. J. DeMaria, C. D. Smith, L. Morgenstern, B. Schirmer

Erschienen in: Surgical Endoscopy | Ausgabe 7/2004

Einloggen, um Zugang zu erhalten

Abstract

Background

Obesity is a growing health problem that contributes to numerous life-threatening or disabling disorders, including coronary artery disease, hypertension, type 2 diabetes mellitus, hyperlipidemia, degenerative joint disease, and obstructive sleep apnea. Significant weight reduction in the morbidly obese improves or reverses associated illness and benefits well-being. The purpose of the SAGES Appropriateness Conference was to summarize the state of the art for open and laparoscopic operations for the morbidly obese.

Methods

The English literature comparing bariatric procedures was reviewed and grouped by level of evidence by three surgeons (BS, LV, and CC). From more than 1,500 articles, all conference participants were provided with reprints and table summaries of no less than 50 selected manuscripts. Ten experts were requested to present reviews and make evidence-based arguments for and against the open and laparoscopic approaches in written format. An expert panel of six surgeons, including an ethicist and patient, commented on implications of data presented. The finalized statement was e-mailed to all participants for approval and comment.

Results

Consensus statements were achieved on various aspects of morbid obesity, including indications for surgery, resolution of comorbid illnesses with significant weight loss, and the importance of committed bariatric program. Our panel of experts agreed, in general, to the advantages of laparoscopic approaches compared to open operations in skilled hands.

Conclusions

Laparoscopic Roux-en-Y gastric bypass (RYGB) affords improved short-term recovery compared to open gastric bypass. Laparoscopic adjustable banding can be performed with lower average mortality than either RYGB or any of the malabsorptive operations, and it produces variable degrees of short-term weight loss. Prospective randomized trials are needed to compare gastric bypass, malabsorptive, and restrictive procedures.
Literatur
1.
Zurück zum Zitat Baltasar, A, Bou, R, Bengochea, M, Arlandis, F, Escriva, C, Miro, J, Martinez, R, Perez, N 2001Duodenal switch: an effective therapy for morbid obesity—intermediate resultsObes Surg15458CrossRef Baltasar, A, Bou, R, Bengochea, M, Arlandis, F, Escriva, C, Miro, J, Martinez, R, Perez, N 2001Duodenal switch: an effective therapy for morbid obesity—intermediate resultsObes Surg15458CrossRef
2.
Zurück zum Zitat Benedetti, G, Mingrone, G, Marcoccia, R, Benedetti, M, Giancaterini, A, Greco, AV, Castagneto, M, Gasbarrini, G 2000Body composition and energy expenditure after weight loss following bariatric surgeryJ Am Coll Nutr19270274PubMed Benedetti, G, Mingrone, G, Marcoccia, R, Benedetti, M, Giancaterini, A, Greco, AV, Castagneto, M, Gasbarrini, G 2000Body composition and energy expenditure after weight loss following bariatric surgeryJ Am Coll Nutr19270274PubMed
3.
Zurück zum Zitat Forestieri, P, Luca, M, Formato, A, Loffredo, A, Santoro, M 1999Continuation of papers presented at the third National Symposium on Laparoscopic Surgery for Morbid Obesity, Naples, Italy, March 26, 1998; restrictive versus malabsorptive procedures: criteria for patient selection.Obes Surg194850CrossRef Forestieri, P, Luca, M, Formato, A, Loffredo, A, Santoro, M 1999Continuation of papers presented at the third National Symposium on Laparoscopic Surgery for Morbid Obesity, Naples, Italy, March 26, 1998; restrictive versus malabsorptive procedures: criteria for patient selection.Obes Surg194850CrossRef
4.
Zurück zum Zitat Gentileschi, P, Kini, S, Catarci, M, Gagner, M 2002Evidence-based medicine: open and laparoscopic bariatric surgerySurg Endosc16736744CrossRefPubMed Gentileschi, P, Kini, S, Catarci, M, Gagner, M 2002Evidence-based medicine: open and laparoscopic bariatric surgerySurg Endosc16736744CrossRefPubMed
5.
Zurück zum Zitat Griffin, WO, Young, VL, Stevenson, CC 1977A prospective comparison of gastric and jejunoileal bypass procedures for morbid obesityAnn Surg186500509PubMed Griffin, WO, Young, VL, Stevenson, CC 1977A prospective comparison of gastric and jejunoileal bypass procedures for morbid obesityAnn Surg186500509PubMed
6.
Zurück zum Zitat Hakansson, T, Andersen, B, Christensen, RF, Christensen, S 1985The influence of jejunoileal ratio on plasma electrolytes and liver function in intestinal bypass for morbid obesity.Scand J Gastroenterol20179182PubMed Hakansson, T, Andersen, B, Christensen, RF, Christensen, S 1985The influence of jejunoileal ratio on plasma electrolytes and liver function in intestinal bypass for morbid obesity.Scand J Gastroenterol20179182PubMed
7.
Zurück zum Zitat Hess, DS, Hess, DW 1998Biliopancreatic diversion with a duodenal switchObes Surg8267282CrossRefPubMed Hess, DS, Hess, DW 1998Biliopancreatic diversion with a duodenal switchObes Surg8267282CrossRefPubMed
8.
Zurück zum Zitat Marceau, P, Hould, FS, Lebel, S, Marceau, S, Biron, S 2001Malabsorptive obesity surgerySurg North Am8111131127 Marceau, P, Hould, FS, Lebel, S, Marceau, S, Biron, S 2001Malabsorptive obesity surgerySurg North Am8111131127
9.
Zurück zum Zitat Marceau, P, Hould, FS, Simard, S, Lebel, S, Bourque, RA, Potvin, M, Biron, S 1998Biliopancreatic diversion with duodenal switchWorld J Surg22947954CrossRefPubMed Marceau, P, Hould, FS, Simard, S, Lebel, S, Bourque, RA, Potvin, M, Biron, S 1998Biliopancreatic diversion with duodenal switchWorld J Surg22947954CrossRefPubMed
10.
Zurück zum Zitat Marinari, GM, Camerini, G, Novelli, GB, Papadia, F, Murelli, F, Marini, P, Adami, GF, Scopinaro, N 2001Outcome of biliopancreatic diversion in subjects with Prader–Willi syndromeObes Surg11491495CrossRefPubMed Marinari, GM, Camerini, G, Novelli, GB, Papadia, F, Murelli, F, Marini, P, Adami, GF, Scopinaro, N 2001Outcome of biliopancreatic diversion in subjects with Prader–Willi syndromeObes Surg11491495CrossRefPubMed
11.
Zurück zum Zitat Mun, MM, Balsiger, BM, Kennedy, FP, Mai, JL, San, MG 1999Malabsorptive procedures for severe obesity: comparison of pancreaticobiliary bypass and very long limb Roux-en-Y gastric bypassJ Gastrointest Surg3607612CrossRefPubMed Mun, MM, Balsiger, BM, Kennedy, FP, Mai, JL, San, MG 1999Malabsorptive procedures for severe obesity: comparison of pancreaticobiliary bypass and very long limb Roux-en-Y gastric bypassJ Gastrointest Surg3607612CrossRefPubMed
12.
Zurück zum Zitat Paiva, D, Bernardes, L, Suretti, L 2002Laparoscopic biliopancreatic diversion: technique and initial resultsObes Surg12358361CrossRefPubMed Paiva, D, Bernardes, L, Suretti, L 2002Laparoscopic biliopancreatic diversion: technique and initial resultsObes Surg12358361CrossRefPubMed
13.
Zurück zum Zitat Rabkin, RA 1998Distal gastric bypass/duodenal switch procedure, Roux-en-Y gastric bypass and biliopancreatic diversion in a community practiceObes Surg85359CrossRefPubMed Rabkin, RA 1998Distal gastric bypass/duodenal switch procedure, Roux-en-Y gastric bypass and biliopancreatic diversion in a community practiceObes Surg85359CrossRefPubMed
14.
Zurück zum Zitat Ren, CJ, Patterson, E, Gagner, M 2000Early results of laparoscopic biliopancreatic diversion with duodenal switch: a case series of 40 consecutive patientsObes Surg10514523CrossRefPubMed Ren, CJ, Patterson, E, Gagner, M 2000Early results of laparoscopic biliopancreatic diversion with duodenal switch: a case series of 40 consecutive patientsObes Surg10514523CrossRefPubMed
15.
Zurück zum Zitat Requarth, JA, Burchard, KW, Colacchio, TA, Stukel, TA, Mott, LA, Greenberg, ER, Weismann, RE 1995Long-term morbidity following jejunoileal bypass; the continuing potential need for surgical reversalArch Surg130318325PubMed Requarth, JA, Burchard, KW, Colacchio, TA, Stukel, TA, Mott, LA, Greenberg, ER, Weismann, RE 1995Long-term morbidity following jejunoileal bypass; the continuing potential need for surgical reversalArch Surg130318325PubMed
16.
Zurück zum Zitat Scheuller, M, Weider, D 2001Bariatric surgery for treatment of sleep apnea syndrome in 15 morbidly obese patients: long-term resultsOtolaryngoi Head Neck Surg125299302CrossRef Scheuller, M, Weider, D 2001Bariatric surgery for treatment of sleep apnea syndrome in 15 morbidly obese patients: long-term resultsOtolaryngoi Head Neck Surg125299302CrossRef
17.
Zurück zum Zitat Scopinaro, N, Adami, GF, Marinari, GM, Gianetta, E, Traverso, E, Friedman, D, Camerini, G, Baschieri, G, Simonelli, A 1998Biliopancreatic diversionWorld J Surg22936946CrossRefPubMed Scopinaro, N, Adami, GF, Marinari, GM, Gianetta, E, Traverso, E, Friedman, D, Camerini, G, Baschieri, G, Simonelli, A 1998Biliopancreatic diversionWorld J Surg22936946CrossRefPubMed
18.
Zurück zum Zitat Scopinaro, N, Gianetta, E, Adami, GF, Friedman, D, Traverso, E, Marinari, GM, Cuneo, S, Vitale, B, Ballari, F, Colombini, M, Baschieri, G, Bachi, V 1996Biliopancreatic diversion for obesity at eighteen yearsSurgery119261268PubMed Scopinaro, N, Gianetta, E, Adami, GF, Friedman, D, Traverso, E, Marinari, GM, Cuneo, S, Vitale, B, Ballari, F, Colombini, M, Baschieri, G, Bachi, V 1996Biliopancreatic diversion for obesity at eighteen yearsSurgery119261268PubMed
19.
Zurück zum Zitat Tataranni, PA, Mingrone, G, Raguso, CA, Gaetano, A, Tacchino, RM, Castagneto, M, Greeo, AV 1996Twenty-four-hour energy and nutrient balance in weight stable post obese patients after biliopancreatic diversionNutrition12239244CrossRefPubMed Tataranni, PA, Mingrone, G, Raguso, CA, Gaetano, A, Tacchino, RM, Castagneto, M, Greeo, AV 1996Twenty-four-hour energy and nutrient balance in weight stable post obese patients after biliopancreatic diversionNutrition12239244CrossRefPubMed
20.
Zurück zum Zitat Ashy, AR, Merdad, AA 1998A prospective study comparing vertical banded gastroplasty versus laparoscopic adjustable gastric banding in the treatment of morbid and superobesityInternational Surg83108110 Ashy, AR, Merdad, AA 1998A prospective study comparing vertical banded gastroplasty versus laparoscopic adjustable gastric banding in the treatment of morbid and superobesityInternational Surg83108110
21.
Zurück zum Zitat DeMaria, EJ, Sugerman, HJ, Meador, JG, et al. 2000High failure rate after laparoscopic adjustable silicone gastric banding for treatment of morbid obesityAnn Surg233809818CrossRef DeMaria, EJ, Sugerman, HJ, Meador, JG,  et al. 2000High failure rate after laparoscopic adjustable silicone gastric banding for treatment of morbid obesityAnn Surg233809818CrossRef
22.
Zurück zum Zitat Wit, LT, Mathus-Vliegen, L, Hey, C, et al. 1999Open versus laparoscopic adjustable silicone gastric banding: a prospective randomized trial for treatment of morbid obesityAnn Surg230800805CrossRefPubMed Wit, LT, Mathus-Vliegen, L, Hey, C,  et al. 1999Open versus laparoscopic adjustable silicone gastric banding: a prospective randomized trial for treatment of morbid obesityAnn Surg230800805CrossRefPubMed
23.
Zurück zum Zitat Doherty, C, Maher, JW, Heitshusen, DS 1998Prospective investigation of complications, reoperations, and sustained weight loss with an adjustable gastric banding device for treatment of morbid obesityJ Gastrointest Surg2102108CrossRefPubMed Doherty, C, Maher, JW, Heitshusen, DS 1998Prospective investigation of complications, reoperations, and sustained weight loss with an adjustable gastric banding device for treatment of morbid obesityJ Gastrointest Surg2102108CrossRefPubMed
24.
Zurück zum Zitat Favretti, F, Cadiere, G, Segato, G, et al. 2002Laparoscopic banding: selection and technique in 830 patientsObes Surg12385390CrossRefPubMed Favretti, F, Cadiere, G, Segato, G,  et al. 2002Laparoscopic banding: selection and technique in 830 patientsObes Surg12385390CrossRefPubMed
25.
Zurück zum Zitat Gentileschi, P, Kini, S, Gagner, M 2002Evidence-based medicine: open and laparoscopic bariatric surgery.Surg Endosc16736744CrossRefPubMed Gentileschi, P, Kini, S, Gagner, M 2002Evidence-based medicine: open and laparoscopic bariatric surgery.Surg Endosc16736744CrossRefPubMed
26.
Zurück zum Zitat O’Brien, PE, Brown, WA, Smith, A, et al. 1999Prospective study of a laparoscopically placed adjustable gastric band in the treatment of morbid obesityBr J Surg86113116CrossRefPubMed O’Brien, PE, Brown, WA, Smith, A,  et al. 1999Prospective study of a laparoscopically placed adjustable gastric band in the treatment of morbid obesityBr J Surg86113116CrossRefPubMed
27.
Zurück zum Zitat Sugerman, HJ, Londrey, GL, Kellum, JM, et al. 1989Weight loss with vertical banded gastroplasty and Roux-y gastric bypass for morbid obesity with selective versus random assignmentAm J Surg15793102CrossRefPubMed Sugerman, HJ, Londrey, GL, Kellum, JM,  et al. 1989Weight loss with vertical banded gastroplasty and Roux-y gastric bypass for morbid obesity with selective versus random assignmentAm J Surg15793102CrossRefPubMed
28.
Zurück zum Zitat Sugerman, HJ, Starkey, IV, Birkenhauer, R 1987A randomized prospective trial of gastric bypass versus vertical banded gastroplasty for morbid obesity and their effects on sweets versus non-sweets eatersAnn Surg205613624PubMed Sugerman, HJ, Starkey, IV, Birkenhauer, R 1987A randomized prospective trial of gastric bypass versus vertical banded gastroplasty for morbid obesity and their effects on sweets versus non-sweets eatersAnn Surg205613624PubMed
29.
Zurück zum Zitat Brolin, RE, et al. 1992Long-limb gastric bypass in the superobese. A prospective randomized studyAnn Surg215387395PubMed Brolin, RE,  et al. 1992Long-limb gastric bypass in the superobese. A prospective randomized studyAnn Surg215387395PubMed
30.
Zurück zum Zitat Choban, PS, Flancbaum, L 2002The effect of roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective randomized clincial trialObes Surg12540545CrossRefPubMed Choban, PS, Flancbaum, L 2002The effect of roux limb lengths on outcome after Roux-en-Y gastric bypass: a prospective randomized clincial trialObes Surg12540545CrossRefPubMed
31.
Zurück zum Zitat Demaria, EJ, et al. 2002Results of 281 consecutive total laparoscopic Roux-en-Y gastric bypasses to treat morbid obesityAnn Surg235640647CrossRefPubMed Demaria, EJ,  et al. 2002Results of 281 consecutive total laparoscopic Roux-en-Y gastric bypasses to treat morbid obesityAnn Surg235640647CrossRefPubMed
32.
Zurück zum Zitat Griffen, WO,Jr, Young, L, Stevenson, CC 1977A prospective comparison of gastric and jejunoileal bypass procedures for morbid obesityAnn Surg186500509PubMed Griffen, WO,Jr, Young, L, Stevenson, CC 1977A prospective comparison of gastric and jejunoileal bypass procedures for morbid obesityAnn Surg186500509PubMed
33.
Zurück zum Zitat Hall, JC, et al. 1990Gastric surgery for morbid obesity. The Adelaide studyAnn Surg211419427PubMed Hall, JC,  et al. 1990Gastric surgery for morbid obesity. The Adelaide studyAnn Surg211419427PubMed
34.
Zurück zum Zitat Higa, KD, et al. 2000Laparoscopic Roux-en-Y gastric bypass for morbid obesity. Technique and preliminary results of our first 400 patientsArch Surg13510291033CrossRefPubMed Higa, KD,  et al. 2000Laparoscopic Roux-en-Y gastric bypass for morbid obesity. Technique and preliminary results of our first 400 patientsArch Surg13510291033CrossRefPubMed
35.
Zurück zum Zitat Laws, HL, Piantadosi, S 1981Superior gastric reduction procedure for morbid obesity. A prospective, randomized trialAnn Surg193334340PubMed Laws, HL, Piantadosi, S 1981Superior gastric reduction procedure for morbid obesity. A prospective, randomized trialAnn Surg193334340PubMed
36.
Zurück zum Zitat Mclean, LD, et al. 1995Surgery for obesity—an update of a randomized trialObes Surg5145150CrossRefPubMed Mclean, LD,  et al. 1995Surgery for obesity—an update of a randomized trialObes Surg5145150CrossRefPubMed
37.
Zurück zum Zitat National Institutes of Health1992Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference statementAm J Surg55615S619S National Institutes of Health1992Gastrointestinal surgery for severe obesity: National Institutes of Health Consensus Development Conference statementAm J Surg55615S619S
38.
Zurück zum Zitat Nguyen, NT, et al. 2001Laparoscopic versus open gastric bypass: a randomized study of outcomes, quality of life, and costsAnn Surg234279289CrossRefPubMed Nguyen, NT,  et al. 2001Laparoscopic versus open gastric bypass: a randomized study of outcomes, quality of life, and costsAnn Surg234279289CrossRefPubMed
39.
Zurück zum Zitat Pories, WJ, et al. 1982The effectiveness of gastric bypass over gastric partion in morbid obesity. Consequence of distal gastric and duodenal exclusionAnn Surg194389399 Pories, WJ,  et al. 1982The effectiveness of gastric bypass over gastric partion in morbid obesity. Consequence of distal gastric and duodenal exclusionAnn Surg194389399
40.
Zurück zum Zitat Schauer, PR, et al. 2000Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesityAnn Surg232515529CrossRefPubMed Schauer, PR,  et al. 2000Outcomes after laparoscopic Roux-en-Y gastric bypass for morbid obesityAnn Surg232515529CrossRefPubMed
41.
Zurück zum Zitat Sugarman, HJ, et al. 1989Weight loss with vertical banded gastroplasty and Roux-Y bypass for morbid obesity with selective versus random assignmentAm J Surg15793102CrossRefPubMed Sugarman, HJ,  et al. 1989Weight loss with vertical banded gastroplasty and Roux-Y bypass for morbid obesity with selective versus random assignmentAm J Surg15793102CrossRefPubMed
42.
Zurück zum Zitat Westling, A, Gustavsson, S 2001Laparoscopic vs open Roux-en-Y gastric bypass: a prospective, randomized trialObes Surg11284292CrossRefPubMed Westling, A, Gustavsson, S 2001Laparoscopic vs open Roux-en-Y gastric bypass: a prospective, randomized trialObes Surg11284292CrossRefPubMed
43.
Zurück zum Zitat Wittgrove, AC, Clark, W 2000Laparoscopic gastric bypass, Roux-en-Y—500 patients: technique and results, with 3–60 month follow-upObes Surg10233239CrossRefPubMed Wittgrove, AC, Clark, W 2000Laparoscopic gastric bypass, Roux-en-Y—500 patients: technique and results, with 3–60 month follow-upObes Surg10233239CrossRefPubMed
Metadaten
Titel
Optimal management of the morbidly obese patient SAGES appropriateness conference statement
verfasst von
D. B. Jones
D. A. Provost
E. J. DeMaria
C. D. Smith
L. Morgenstern
B. Schirmer
Publikationsdatum
01.07.2004
Erschienen in
Surgical Endoscopy / Ausgabe 7/2004
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-004-8132-6

Weitere Artikel der Ausgabe 7/2004

Surgical Endoscopy 7/2004 Zur Ausgabe

Letter to the editor

The authors reply

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 Ablationstherapie Nachrichten

Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Ureterstriktur: Innovative OP-Technik bewährt sich

19.04.2024 EAU 2024 Kongressbericht

Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.