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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 12/2004

01.12.2004 | Review

Catheter-related infections in children treated with hemodialysis

verfasst von: Fabio Paglialonga, Susanna Esposito, Alberto Edefonti, Nicola Principi

Erschienen in: Pediatric Nephrology | Ausgabe 12/2004

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Abstract

Infectious complications of the central venous catheter (CVC) are a major source of morbidity among children treated with hemodialysis (HD), with catheter-related bloodstream infections (CRBSI) being the most important clinical manifestations. As only a few studies of children on HD have been published, the management of CVC-related infections in this population is mainly based on data derived from adults or occasionally from children not affected by end-stage renal disease (ESRD). The aim of this review is to discuss current knowledge concerning the epidemiology, prevention, and treatment of catheter-related infections in children on HD. Catheters impregnated with antibiotics/antiseptics, lock antibiotic prophylaxis, nasal mupirocin, and the application of ointments at the exit-site have all been proposed as means of reducing the risk of CVC infections, but their real efficacy in the pediatric population has not yet been demonstrated. Furthermore, it is not clear how long antibiotic therapy should be continued, and there is still debate as to whether the catheter has to be removed. We propose some practical guidelines for the management of CRBSI in children with percutaneously inserted and surgically implanted HD catheters, but a number of unresolved clinical issues still remain, which will require prospective clinical trials specifically performed in pediatric patients with ESRD.
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Metadaten
Titel
Catheter-related infections in children treated with hemodialysis
verfasst von
Fabio Paglialonga
Susanna Esposito
Alberto Edefonti
Nicola Principi
Publikationsdatum
01.12.2004
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 12/2004
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-004-1596-8

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