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Erschienen in: Supportive Care in Cancer 1/2010

01.03.2010 | Meeting Highlights

Chemotherapy-induced nausea and vomiting: contemporary approaches to optimal management

Proceedings from a symposium at the 2008 Multinational Association of Supportive Care in Cancer (MASCC) Annual Meeting

verfasst von: Steven Grunberg, Rebecca A. Clark-Snow, Jim Koeller

Erschienen in: Supportive Care in Cancer | Sonderheft 1/2010

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Abstract

Introduction

Chemotherapy-induced nausea and vomiting remains a significant problem for cancer patients.

Discussion

Patient factors such as polypharmacy, medication costs, mucositis, and depression may hinder good antiemetic control, while high workloads, poor communication, and underestimation of the problem on the part of healthcare professionals also play a role. Improving outcomes requires accurate assessment of risk factors, use of guidelines, and better adherence to antiemetic regimens.

Conclusion

Extended-release formulations and new delivery systems such as transdermal patches, nasal sprays, and pumps provide a new strategy that may improve patient outcomes.
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Literatur
1.
Zurück zum Zitat Aapro MS, Molassiotis A, Olver I (2005) Anticipatory nausea and vomiting. Support Care Cancer 13:117–121CrossRefPubMed Aapro MS, Molassiotis A, Olver I (2005) Anticipatory nausea and vomiting. Support Care Cancer 13:117–121CrossRefPubMed
2.
Zurück zum Zitat Basch E, Iasonos A, Barz A, Culkin A, Kris MG, Artz D, Fearn P, Speakman J, Farquhar R, Scher HI, McCabe M, Schraq D (2007) Long-term toxicity monitoring via electronic patient-reported outcomes in patients receiving chemotherapy. J Clin Oncol 25:5374–5380CrossRefPubMed Basch E, Iasonos A, Barz A, Culkin A, Kris MG, Artz D, Fearn P, Speakman J, Farquhar R, Scher HI, McCabe M, Schraq D (2007) Long-term toxicity monitoring via electronic patient-reported outcomes in patients receiving chemotherapy. J Clin Oncol 25:5374–5380CrossRefPubMed
3.
Zurück zum Zitat Briesacher BA, Gurwitz JH, Soumerai SB (2007) Patients at-risk for cost-related medication nonadherence: a review of the literature. Gen Intern Med 22:864–871CrossRef Briesacher BA, Gurwitz JH, Soumerai SB (2007) Patients at-risk for cost-related medication nonadherence: a review of the literature. Gen Intern Med 22:864–871CrossRef
4.
Zurück zum Zitat Butow PN, Dunn SM, Tattersall MH, Jones QJ (1995) Computer-based interaction analysis of the cancer consultation. Br J Cancer 71:1115–1121PubMed Butow PN, Dunn SM, Tattersall MH, Jones QJ (1995) Computer-based interaction analysis of the cancer consultation. Br J Cancer 71:1115–1121PubMed
5.
Zurück zum Zitat Cervený P, Bortlik M, Kubena A, Vicek J, Lakatos PL, Lukás M (2007) Nonadherence in inflammatory bowel disease: results of factor analysis. Inflamm Bowel Dis 13:1244–1249CrossRefPubMed Cervený P, Bortlik M, Kubena A, Vicek J, Lakatos PL, Lukás M (2007) Nonadherence in inflammatory bowel disease: results of factor analysis. Inflamm Bowel Dis 13:1244–1249CrossRefPubMed
6.
Zurück zum Zitat Coates A, Abraham S, Kaye SB, Sowerbutts T, Frewin C, Fox RM, Tattersall MH (1983) On the receiving end—patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19:203–208CrossRefPubMed Coates A, Abraham S, Kaye SB, Sowerbutts T, Frewin C, Fox RM, Tattersall MH (1983) On the receiving end—patient perception of the side-effects of cancer chemotherapy. Eur J Cancer Clin Oncol 19:203–208CrossRefPubMed
7.
Zurück zum Zitat de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, van Beurden V, Stoter G, Verweij J (1997) Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer 76:1055–1061PubMed de Boer-Dennert M, de Wit R, Schmitz PI, Djontono J, van Beurden V, Stoter G, Verweij J (1997) Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer 76:1055–1061PubMed
8.
Zurück zum Zitat DiMatteo MR, Lepper HS, Croghan TW (2000) Depression is a risk factor for noncompliance with medical treatment. Arch Intern Med 160:2101–2107CrossRefPubMed DiMatteo MR, Lepper HS, Croghan TW (2000) Depression is a risk factor for noncompliance with medical treatment. Arch Intern Med 160:2101–2107CrossRefPubMed
9.
Zurück zum Zitat Dix SP, Cord MK, Howard SJ, Coon JL, Belt RJ, Geller RB (1999) Safety and efficacy of a continuous infusion, patient controlled antiemetic pump to facilitate outpatient administration of high-dose chemotherapy. Bone Marrow Transplant 24:561–566CrossRefPubMed Dix SP, Cord MK, Howard SJ, Coon JL, Belt RJ, Geller RB (1999) Safety and efficacy of a continuous infusion, patient controlled antiemetic pump to facilitate outpatient administration of high-dose chemotherapy. Bone Marrow Transplant 24:561–566CrossRefPubMed
10.
Zurück zum Zitat Einhorn LH, Rapoport B, Koeller J, Grunberg SM, Feyer P, Rittenberg C, Aapro M (2005) Antiemetic therapy for multiple-day chemotherapy and high-dose chemotherapy with stem cell transplant: review and consensus statement. Support Care Cancer 13:112–116CrossRefPubMed Einhorn LH, Rapoport B, Koeller J, Grunberg SM, Feyer P, Rittenberg C, Aapro M (2005) Antiemetic therapy for multiple-day chemotherapy and high-dose chemotherapy with stem cell transplant: review and consensus statement. Support Care Cancer 13:112–116CrossRefPubMed
11.
Zurück zum Zitat Einhorn LH, Brames MJ, Dreicer R, Nichols CR, Cullen MT Jr, Bubalo J (2007) Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy for germ cell cancer. Support Care Cancer 15:1293–1300CrossRefPubMed Einhorn LH, Brames MJ, Dreicer R, Nichols CR, Cullen MT Jr, Bubalo J (2007) Palonosetron plus dexamethasone for prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple-day cisplatin chemotherapy for germ cell cancer. Support Care Cancer 15:1293–1300CrossRefPubMed
12.
Zurück zum Zitat Eisenberg P, Figueroa-Vadillo J, Zamora R, Charu V, Hajdenberg J, Cartmell A, Macciocchi A, Grunberg S, 99-04 Palonosetron Study Group (2003) Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist. Cancer 98:2473–2482CrossRefPubMed Eisenberg P, Figueroa-Vadillo J, Zamora R, Charu V, Hajdenberg J, Cartmell A, Macciocchi A, Grunberg S, 99-04 Palonosetron Study Group (2003) Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist. Cancer 98:2473–2482CrossRefPubMed
13.
Zurück zum Zitat Gavini E, Hegge AB, Rassu G, Sanna V, Testa C, Pirisino G, Karlsen J, Giunchedi P (2006) Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies. Int J Pharm 307:9–15CrossRefPubMed Gavini E, Hegge AB, Rassu G, Sanna V, Testa C, Pirisino G, Karlsen J, Giunchedi P (2006) Nasal administration of carbamazepine using chitosan microspheres: in vitro/in vivo studies. Int J Pharm 307:9–15CrossRefPubMed
14.
Zurück zum Zitat Gill D, Howell J (2008) Pharmacokinetics and bioavailability of transdermal granisetron after a 6-day application of three patch sizes, compared to 2 mg once-daily oral dose of granisetron for 5 days. Abstracts of the 2008 International MASCC/ISOO Symposium held in Houston, Texas, June 26-28, 2008. Abstract 01-006 Gill D, Howell J (2008) Pharmacokinetics and bioavailability of transdermal granisetron after a 6-day application of three patch sizes, compared to 2 mg once-daily oral dose of granisetron for 5 days. Abstracts of the 2008 International MASCC/ISOO Symposium held in Houston, Texas, June 26-28, 2008. Abstract 01-006
15.
Zurück zum Zitat Gorard DA (2006) Escalating polypharmacy. Q J Med 99:797–800 Gorard DA (2006) Escalating polypharmacy. Q J Med 99:797–800
16.
Zurück zum Zitat Gralla RJ, Itri L, Pisko SE, Squillante AE, Kelsen DP, Braun DW Jr, Bordin LA, Braun TJ, Young CW (1981) Antiemetic efficacy of high-dose metrocloramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced vomiting. N Engl J Med 305:905–909PubMedCrossRef Gralla RJ, Itri L, Pisko SE, Squillante AE, Kelsen DP, Braun DW Jr, Bordin LA, Braun TJ, Young CW (1981) Antiemetic efficacy of high-dose metrocloramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced vomiting. N Engl J Med 305:905–909PubMedCrossRef
17.
Zurück zum Zitat Gralla RJ, Osoba D, Kris MG, Kirkbride P, Hesketh PJ, Chinnery LW et al (1999) Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. J Clin Oncol 12:2971–2994 Gralla RJ, Osoba D, Kris MG, Kirkbride P, Hesketh PJ, Chinnery LW et al (1999) Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. J Clin Oncol 12:2971–2994
18.
Zurück zum Zitat Grunberg SM, Deuson RR, Mavros P, Geling O, Hansen M, Cruciani G et al (2004) Incidence of chemotherapy-induced nausea and emesis after modern antiemetics. Cancer 100:2261–2268CrossRefPubMed Grunberg SM, Deuson RR, Mavros P, Geling O, Hansen M, Cruciani G et al (2004) Incidence of chemotherapy-induced nausea and emesis after modern antiemetics. Cancer 100:2261–2268CrossRefPubMed
19.
Zurück zum Zitat Grunberg SM, Gabrial N, Clark G (2007) Phase III trial of transdermal granisetron patch (Sancuso) compared to oral granisetron (OG) for chemotherapy-induced nausea and vomiting (CINV) after multi-day moderately emetogenic (MEC) or highly emetogenic (HEC) chemotherapy. Abstracts of the 2007 International MASCC/ISOO Symposium held in St. Gallen, Switzerland, June 27–30, 2007. Abstract P-18. Grunberg SM, Gabrial N, Clark G (2007) Phase III trial of transdermal granisetron patch (Sancuso) compared to oral granisetron (OG) for chemotherapy-induced nausea and vomiting (CINV) after multi-day moderately emetogenic (MEC) or highly emetogenic (HEC) chemotherapy. Abstracts of the 2007 International MASCC/ISOO Symposium held in St. Gallen, Switzerland, June 27–30, 2007. Abstract P-18.
20.
Zurück zum Zitat Herrstedt J (2004) Risk-benefit of antiemetics in prevention and treatment of chemotherapy-induced nausea and vomiting. Expert Opin Drug Saf 3:231–248CrossRefPubMed Herrstedt J (2004) Risk-benefit of antiemetics in prevention and treatment of chemotherapy-induced nausea and vomiting. Expert Opin Drug Saf 3:231–248CrossRefPubMed
21.
Zurück zum Zitat Herrstedt J, Aapro MS, Smuth JF, Del Favero A (1998) Corticosteroids, dopamine antagonists and other drugs. Support Care Cancer 6:204–214CrossRefPubMed Herrstedt J, Aapro MS, Smuth JF, Del Favero A (1998) Corticosteroids, dopamine antagonists and other drugs. Support Care Cancer 6:204–214CrossRefPubMed
22.
Zurück zum Zitat Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, Chawla SP, Carides AD, Ianus J, Elmer ME, Evans JK, Beck K, Reines S, Horgan KJ, Aprepitant Protocol 052 Study Group (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin—the Aprepitant Protocol 052 Study. J Clin Oncol 21:4112–4119CrossRefPubMed Hesketh PJ, Grunberg SM, Gralla RJ, Warr DG, Roila F, de Wit R, Chawla SP, Carides AD, Ianus J, Elmer ME, Evans JK, Beck K, Reines S, Horgan KJ, Aprepitant Protocol 052 Study Group (2003) The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin—the Aprepitant Protocol 052 Study. J Clin Oncol 21:4112–4119CrossRefPubMed
23.
Zurück zum Zitat Horne R, Graupner L, Frost S, Weinman J, Wright SM, Hankins M (2004) Medicine in a multi-cultural society: the effect of cultural background on beliefs about medications. Soc Sci Med 59:1307–1313CrossRefPubMed Horne R, Graupner L, Frost S, Weinman J, Wright SM, Hankins M (2004) Medicine in a multi-cultural society: the effect of cultural background on beliefs about medications. Soc Sci Med 59:1307–1313CrossRefPubMed
24.
Zurück zum Zitat Ihbe-Heffinger A, Ehlken B, Bernard R, Berger K, Peschel C, Eichler HG, Deuson R, Thödtmann J, Lordick F (2004) The impact of delayed chemotherapy-induced nausea and vomiting on patients, health resource utilization and costs in German cancer centers. Ann Oncol 15:526–536CrossRefPubMed Ihbe-Heffinger A, Ehlken B, Bernard R, Berger K, Peschel C, Eichler HG, Deuson R, Thödtmann J, Lordick F (2004) The impact of delayed chemotherapy-induced nausea and vomiting on patients, health resource utilization and costs in German cancer centers. Ann Oncol 15:526–536CrossRefPubMed
25.
Zurück zum Zitat Jones E, Koyama T, Ho RH, Kuttesch J, Shankar S, Whitlock JA, Cartwright J, Frangoul H (2007) Safety and efficacy of a continuous infusion, patient-controlled antiemetic pump for children receiving emetogenic chemotherapy. Pediatr Blood Cancer 48:330–332CrossRefPubMed Jones E, Koyama T, Ho RH, Kuttesch J, Shankar S, Whitlock JA, Cartwright J, Frangoul H (2007) Safety and efficacy of a continuous infusion, patient-controlled antiemetic pump for children receiving emetogenic chemotherapy. Pediatr Blood Cancer 48:330–332CrossRefPubMed
26.
Zurück zum Zitat Jordan K, Sippel C, Schmoll H-J (2007) Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations. Oncologist 12:1143–1150CrossRefPubMed Jordan K, Sippel C, Schmoll H-J (2007) Guidelines for antiemetic treatment of chemotherapy-induced nausea and vomiting: past, present, and future recommendations. Oncologist 12:1143–1150CrossRefPubMed
27.
Zurück zum Zitat Kaufman DW, Kelly P, Rosenberg L, Anderson TE, Mitchell AA (2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 287:337–344CrossRefPubMed Kaufman DW, Kelly P, Rosenberg L, Anderson TE, Mitchell AA (2002) Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA 287:337–344CrossRefPubMed
28.
Zurück zum Zitat Kimbell JS, Segal RA, Asgharian B, Wong BA, Schroeter JD, Southall JP, Dickens CJ, Brace G, Miller FJ (2007) Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages. J Aerosol Med 20:59–74CrossRefPubMed Kimbell JS, Segal RA, Asgharian B, Wong BA, Schroeter JD, Southall JP, Dickens CJ, Brace G, Miller FJ (2007) Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages. J Aerosol Med 20:59–74CrossRefPubMed
29.
Zurück zum Zitat Klocker N, Hanschke W, Toussaint S, Verse T (2001) Scopolamine nasal spray in motion sickness: a randomized, controlled, and crossover study for the comparison of two scopolamine nasal sprays with oral dimenhydrinate and placebo. Eur J Pharm Sci 13:227–232CrossRefPubMed Klocker N, Hanschke W, Toussaint S, Verse T (2001) Scopolamine nasal spray in motion sickness: a randomized, controlled, and crossover study for the comparison of two scopolamine nasal sprays with oral dimenhydrinate and placebo. Eur J Pharm Sci 13:227–232CrossRefPubMed
30.
Zurück zum Zitat Liau CT, Chu N-M, Liu H-E, Dueson R, Lien J, Chen J-S (2005) Incidence of chemotherapy-induced nausea and vomiting in Taiwan: physicians’ and nurses’ estimation vs. patients’ reported outcomes. Support Care Cancer 13:277–286CrossRefPubMed Liau CT, Chu N-M, Liu H-E, Dueson R, Lien J, Chen J-S (2005) Incidence of chemotherapy-induced nausea and vomiting in Taiwan: physicians’ and nurses’ estimation vs. patients’ reported outcomes. Support Care Cancer 13:277–286CrossRefPubMed
31.
Zurück zum Zitat Mardby A-C, Akerlind I, Jorgensen T (2007) Beliefs about medicines and self-reported adherence among pharmacy clients. Patient Educ Couns 69:158–164PubMed Mardby A-C, Akerlind I, Jorgensen T (2007) Beliefs about medicines and self-reported adherence among pharmacy clients. Patient Educ Couns 69:158–164PubMed
32.
Zurück zum Zitat Martin M, Diaz-Rubio E, Sanchez A, Almenarez J, Lopez-Vega M (1990) The natural course of emesis after carboplatin treatment. Acta Oncol 29:593–595CrossRefPubMed Martin M, Diaz-Rubio E, Sanchez A, Almenarez J, Lopez-Vega M (1990) The natural course of emesis after carboplatin treatment. Acta Oncol 29:593–595CrossRefPubMed
33.
Zurück zum Zitat McInnes FJ, O’Mahony B, Lindsay B, Band J, Wilson CG, Hodges LA, Stevens HN (2007) Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scinitigraphy. Eur J Pharm Sci 31:25–31CrossRefPubMed McInnes FJ, O’Mahony B, Lindsay B, Band J, Wilson CG, Hodges LA, Stevens HN (2007) Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scinitigraphy. Eur J Pharm Sci 31:25–31CrossRefPubMed
34.
Zurück zum Zitat Morrow DG, Weiner M, Steinley D, Young J, Murray MD (2007) Patients’ health literacy and experience with instructions influence preferences for heart failure medication instructions. J Aging Health 19:575–593CrossRefPubMed Morrow DG, Weiner M, Steinley D, Young J, Murray MD (2007) Patients’ health literacy and experience with instructions influence preferences for heart failure medication instructions. J Aging Health 19:575–593CrossRefPubMed
35.
Zurück zum Zitat Murphy BA (2007) Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy. J Support Oncol 5:13–21PubMed Murphy BA (2007) Clinical and economic consequences of mucositis induced by chemotherapy and/or radiation therapy. J Support Oncol 5:13–21PubMed
36.
Zurück zum Zitat Newman SP, Steed KP, Hardy JG, Wilding IR, Hooper G, Sparrow RA (1994) The distribution of an intranasal insulin formulation in healthy volunteers: effect of different administration techniques. J Pharm Pharmacol 46:657–660PubMed Newman SP, Steed KP, Hardy JG, Wilding IR, Hooper G, Sparrow RA (1994) The distribution of an intranasal insulin formulation in healthy volunteers: effect of different administration techniques. J Pharm Pharmacol 46:657–660PubMed
37.
Zurück zum Zitat Nolte MJ, Berkery R, Pizzo B, Baltzer L, Grossano D, Lucarelli CD, Kris MG (1998) Assuring the optimal use of serotonin antagonist antiemetics: the process for development and implementation of institutional antiemetic guidelines at Memorial Sloan–Kettering Cancer Center. J Clin Oncol 16:771–778PubMed Nolte MJ, Berkery R, Pizzo B, Baltzer L, Grossano D, Lucarelli CD, Kris MG (1998) Assuring the optimal use of serotonin antagonist antiemetics: the process for development and implementation of institutional antiemetic guidelines at Memorial Sloan–Kettering Cancer Center. J Clin Oncol 16:771–778PubMed
38.
Zurück zum Zitat Anonymous (2007) Oral mucosistis due to cancer treatments. La Revue Prescrire 27:286-288 Anonymous (2007) Oral mucosistis due to cancer treatments. La Revue Prescrire 27:286-288
39.
Zurück zum Zitat Osoba D, Zee B, Warr D, Latreille J, Kaizer L, Pater J (1997) Effect of postchemotherapy nausea and vomiting on health-related quality of life. Support Care Cancer 5:307–313CrossRefPubMed Osoba D, Zee B, Warr D, Latreille J, Kaizer L, Pater J (1997) Effect of postchemotherapy nausea and vomiting on health-related quality of life. Support Care Cancer 5:307–313CrossRefPubMed
40.
Zurück zum Zitat Pagano IS, Gotay CG (2005) Ethnic differential item functioning in the assessment of quality of life in cancer patients. Health Qual Life Outcomes 3:60CrossRefPubMed Pagano IS, Gotay CG (2005) Ethnic differential item functioning in the assessment of quality of life in cancer patients. Health Qual Life Outcomes 3:60CrossRefPubMed
41.
Zurück zum Zitat Penn RD, Kroin JS (1987) Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 66:181–185CrossRefPubMed Penn RD, Kroin JS (1987) Long-term intrathecal baclofen infusion for treatment of spasticity. J Neurosurg 66:181–185CrossRefPubMed
42.
Zurück zum Zitat Pirl WF (2004) Evidence report on the occurrence, assessment, and treatment of depression in cancer patients. J Natl Cancer Inst Monographs 32:32–39CrossRefPubMed Pirl WF (2004) Evidence report on the occurrence, assessment, and treatment of depression in cancer patients. J Natl Cancer Inst Monographs 32:32–39CrossRefPubMed
43.
Zurück zum Zitat Pirl WF, Temel JS, Billings A, Dahlin C, Jackson V, Prigerson HG, Greer J, Lynch TJ (2008) Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot study. Psychosomatics 49:218–224CrossRefPubMed Pirl WF, Temel JS, Billings A, Dahlin C, Jackson V, Prigerson HG, Greer J, Lynch TJ (2008) Depression after diagnosis of advanced non-small cell lung cancer and survival: a pilot study. Psychosomatics 49:218–224CrossRefPubMed
44.
Zurück zum Zitat Pollak KI, Arnold RM, Jeffreys AS, Alexander SC, Olsen MK, Abernethy AP, Sugg Skinner C, Rodriguez KL, Tulsky JA (2007) Oncologist communication about emotion during visits with patients with advanced cancer. J Clin Oncol 25:5748–5752CrossRefPubMed Pollak KI, Arnold RM, Jeffreys AS, Alexander SC, Olsen MK, Abernethy AP, Sugg Skinner C, Rodriguez KL, Tulsky JA (2007) Oncologist communication about emotion during visits with patients with advanced cancer. J Clin Oncol 25:5748–5752CrossRefPubMed
45.
Zurück zum Zitat Repetto L (2003) Greater risks of chemotherapy toxicity in elderly patients with cancer. J Support Oncol 1(suppl 2):18–24PubMed Repetto L (2003) Greater risks of chemotherapy toxicity in elderly patients with cancer. J Support Oncol 1(suppl 2):18–24PubMed
46.
Zurück zum Zitat Schwartzberg LS (2007) Chemotherapy-induced nausea and vomiting: which antiemetic for which therapy? Oncology 21:946–953PubMed Schwartzberg LS (2007) Chemotherapy-induced nausea and vomiting: which antiemetic for which therapy? Oncology 21:946–953PubMed
47.
Zurück zum Zitat Shih Y-CT XuY, Elting LS (2007) Costs of uncontrolled chemotherapy-induced nausea and vomiting among working-age cancer patients receiving highly or moderately emetogenic chemotherapy. Cancer 110:678–685CrossRef Shih Y-CT XuY, Elting LS (2007) Costs of uncontrolled chemotherapy-induced nausea and vomiting among working-age cancer patients receiving highly or moderately emetogenic chemotherapy. Cancer 110:678–685CrossRef
48.
Zurück zum Zitat Taylor JA, Winter L, Geyer LJ, Hawkins DS (2006) Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia. Cancer 107:1400–1406CrossRefPubMed Taylor JA, Winter L, Geyer LJ, Hawkins DS (2006) Oral outpatient chemotherapy medication errors in children with acute lymphoblastic leukemia. Cancer 107:1400–1406CrossRefPubMed
49.
Zurück zum Zitat Valle AE, Wisniewski T, Isabel J, Vadillo F, Burke TA, Martinez Corona M (2006) Incidence of chemotherapy-induced nausea and vomiting in Mexico: healthcare provider predictions versus observed. Curr Med Res Opin 22:2403–2410CrossRef Valle AE, Wisniewski T, Isabel J, Vadillo F, Burke TA, Martinez Corona M (2006) Incidence of chemotherapy-induced nausea and vomiting in Mexico: healthcare provider predictions versus observed. Curr Med Res Opin 22:2403–2410CrossRef
50.
Zurück zum Zitat Wengstrom Y, Haggmark C (1998) Assessing nursing problems of importance for the development of nursing care in a radiation therapy department. Cancer Nurs 21:50–56CrossRefPubMed Wengstrom Y, Haggmark C (1998) Assessing nursing problems of importance for the development of nursing care in a radiation therapy department. Cancer Nurs 21:50–56CrossRefPubMed
51.
Zurück zum Zitat White PF, Tang J, Song D, Coleman JE, Wender RH, Oqunnaiike B, Sloninsky A, Kapu R, Shah M, Webb T (2007) Transdermal scopolamine: an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms. Anesth Analg 104:92–96CrossRefPubMed White PF, Tang J, Song D, Coleman JE, Wender RH, Oqunnaiike B, Sloninsky A, Kapu R, Shah M, Webb T (2007) Transdermal scopolamine: an alternative to ondansetron and droperidol for the prevention of postoperative and postdischarge emetic symptoms. Anesth Analg 104:92–96CrossRefPubMed
53.
Zurück zum Zitat Winkeljohn DL (2007) Oral chemotherapy medications: the need for a nurse’s touch. Clin J Oncol Nurs 11:793–796CrossRefPubMed Winkeljohn DL (2007) Oral chemotherapy medications: the need for a nurse’s touch. Clin J Oncol Nurs 11:793–796CrossRefPubMed
54.
Zurück zum Zitat Woo JS (2006) Nasal absorption studies of granisetron in rats using a validated high-performance liquid chromatographic method with mass spectrometric detection. Arch Pharm Res 30:778–784CrossRef Woo JS (2006) Nasal absorption studies of granisetron in rats using a validated high-performance liquid chromatographic method with mass spectrometric detection. Arch Pharm Res 30:778–784CrossRef
55.
Zurück zum Zitat Zaki NM, Mortada ND, Awad GAS, Abd ElHady SS (2006) Rapid-onset intranasal delivery of metoclopramide hydrochloride part II: safety of various absorption enhancers and pharmacokinetic evaluation. Int J Pharm 327:97–103CrossRefPubMed Zaki NM, Mortada ND, Awad GAS, Abd ElHady SS (2006) Rapid-onset intranasal delivery of metoclopramide hydrochloride part II: safety of various absorption enhancers and pharmacokinetic evaluation. Int J Pharm 327:97–103CrossRefPubMed
56.
Zurück zum Zitat Zarowitz BJ (2007) Fixed-dose combinations for improving medication adherence in assisted living environments. Geriatr Nurs 28:341–345CrossRefPubMed Zarowitz BJ (2007) Fixed-dose combinations for improving medication adherence in assisted living environments. Geriatr Nurs 28:341–345CrossRefPubMed
Metadaten
Titel
Chemotherapy-induced nausea and vomiting: contemporary approaches to optimal management
Proceedings from a symposium at the 2008 Multinational Association of Supportive Care in Cancer (MASCC) Annual Meeting
verfasst von
Steven Grunberg
Rebecca A. Clark-Snow
Jim Koeller
Publikationsdatum
01.03.2010
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe Sonderheft 1/2010
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-009-0807-z

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