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24.10.2018 | Original Article

Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes

verfasst von: Emanuela Scarpi, Monia Dall’Agata, Vittorina Zagonel, Teresa Gamucci, Raffaella Bertè, Elisabetta Sansoni, Elena Amaducci, Chiara Maria Broglia, Sara Alquati, Ferdinando Garetto, Stefania Schiavon, Silvia Quadrini, Elena Orlandi, Andrea Casadei Gardini, Silvia Ruscelli, Daris Ferrari, Maria Simona Pino, Roberto Bortolussi, Federica Negri, Silvia Stragliotto, Filomena Narducci, Martina Valgiusti, Alberto Farolfi, Oriana Nanni, Romina Rossi, Marco Maltoni, on behalf of the Early Palliative Care Italian Study Group (EPCISG)

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2019

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Abstract

Purpose

Early palliative care (EPC) has shown a positive impact on quality of life (QoL), quality of care, and healthcare costs. We evaluated such effects in patients with advanced gastric cancer.

Methods

In this prospective, multicenter study, 186 advanced gastric cancer patients were randomized 1:1 to receive standard cancer care (SCC) plus on-demand EPC (standard arm) or SCC plus systematic EPC (interventional arm). Primary outcome was a change in QoL between randomization (T0) and T1 (12 weeks after T0) in the Trial Outcome Index (TOI) scores evaluated through the Functional Assessment of Cancer Therapy-Gastric questionnaire. Secondary outcomes were patient mood, overall survival, and family satisfaction with healthcare and care aggressiveness.

Results

The mean change in TOI scores from T0 to T1 was − 1.30 (standard deviation (SD) 20.01) for standard arm patients and 1.65 (SD 22.38) for the interventional group, with a difference of 2.95 (95% CI − 4.43 to 10.32) (p = 0.430). The change in mean Gastric Cancer Subscale values for the standard arm was 0.91 (SD 14.14) and 3.19 (SD 15.25) for the interventional group, with a difference of 2.29 (95% CI − 2.80 to 7.38) (p = 0.375). Forty-three percent of patients in the standard arm received EPC.

Conclusions

Our results indicated a slight, albeit not significant, benefit from EPC. Findings on EPC studies may be underestimated in the event of suboptimally managed issues: type of intervention, shared decision-making process between oncologists and PC physicians, risk of standard arm contamination, study duration, timeliness of assessment of primary outcomes, timeliness of cohort inception, and recruitment of patients with a significant symptom burden.

Clinical trial registration

ClinicalTrials.gov (NCT01996540).

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Titel: Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes
verfasst von: Emanuela Scarpi
Monia Dall’Agata
Vittorina Zagonel
Teresa Gamucci
Raffaella Bertè
Elisabetta Sansoni
Elena Amaducci
Chiara Maria Broglia
Sara Alquati
Ferdinando Garetto
Stefania Schiavon
Silvia Quadrini
Elena Orlandi
Andrea Casadei Gardini
Silvia Ruscelli
Daris Ferrari
Maria Simona Pino
Roberto Bortolussi
Federica Negri
Silvia Stragliotto
Filomena Narducci
Martina Valgiusti
Alberto Farolfi
Oriana Nanni
Romina Rossi
Marco Maltoni
on behalf of the Early Palliative Care Italian Study Group (EPCISG)
Publikationsdatum: 24.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 7/2019
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4517-2

Springer Medizin

Systematic vs. on-demand early palliative care in gastric cancer patients: a randomized clinical trial assessing patient and healthcare service outcomes