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06.11.2020 | Original Article

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

verfasst von: Wanessa Miranda-Silva, Wagner Gomes-Silva, Yehuda Zadik, Noam Yarom, Abdul Rahman Al-Azri, Catherine H. L. Hong, Anura Ariyawardana, Deborah P. Saunders, M. Elvira Correa, Praveen R. Arany, Joanne Bowen, Karis Kin Fong Cheng, Wim J. E. Tissing, Paolo Bossi, Sharon Elad, On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)

Erschienen in: Supportive Care in Cancer | Ausgabe 7/2021

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Abstract

Objective

The aim of this sub-analysis was to highlight the MASCC/ISOO clinical practice guidelines for the management of oral mucositis (OM) in pediatric patients and to present unique considerations in this patient population.

Methods

This sub-analysis of the pediatric patient population is based on the systematic review conducted by the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISSO) published in 2019/2020. Studies were scored and assigned a level of evidence based on previously published criteria. Data regarding adverse effects and compliance was collected from the original publications.

Results

A total of 45 papers were included and assessed in this sub-analysis, including 21 randomized controlled trials (RCTs). Chewing gum was demonstrated to be not effective in preventing OM in pediatric cancer patients in 2 RCTs. The efficacy of all other interventions could not be determined based on the available literature.

Conclusion

There is limited or conflicting evidence about interventions for the management of OM in pediatric cancer patients, except for chewing gum which was ineffective for prevention. Therefore, currently, data from adult studies may need to be extrapolated for the management of pediatric patients. Honey and photobiomodulation therapy in this patient population had encouraging potential. Implementation of a basic oral care protocol is advised amid lack of high level of evidence studies.

Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J, Hayden V, Eilers J, Epstein JB, LeVeque FG, Miller C, Peterson DE, Schubert MM, Spijkervet FKL, Horowitz M (2001) Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol. 19(8):2201–2205PubMed

He M, Zhang B, Shen N, Wu N, Sun J (2018) A systematic review and meta-analysis of the effect of low-level laser therapy (LLLT) on chemotherapy-induced oral mucositis in pediatric and young patients. Eur J Pediatr. 177(1):7–17PubMed

Mazhari F, Shirazi AS, Shabzendehdar M (2019) Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta-analysis. Pediatr Blood Cancer. 66(3):e27403PubMed

Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, Popplewell L, Maghami E (2012) Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin. 62(6):400–422PubMed

Cohen J, Donnelly JP, Worsley AM, Catovsky D, Goldman JM, Galton DA (1983) Septicaemia caused by viridans streptococci in neutropenic patients with leukaemia. Lancet. 2(8365-66):1452–1454PubMed

Elting LS, Bodey GP, Keefe BH (1992) Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors. Clin Infect Dis. 14(6):1201–1207PubMed

Bezinelli LM, de Paula EF, da Graca Lopes RM, Biazevic MG, de Paula EC, Correa L et al (2014) Cost-effectiveness of the introduction of specialized oral care with laser therapy in hematopoietic stem cell transplantation. Hematol Oncol. 32(1):31–39PubMed

Ariyawardana A, Cheng KKF, Kandwal A, Tilly V, Al-Azri AR, Galiti D et al (2019) Systematic review of anti-inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 27(10):3985–3995PubMed

Bowen JM, Gibson RJ, Coller JK, Blijlevens N, Bossi P, Al-Dasooqi N et al (2019) Systematic review of agents for the management of cancer treatment-related gastrointestinal mucositis and clinical practice guidelines. Support Care Cancer. 27(10):4011–4022PubMed

10.

Correa MEP, Cheng KKF, Chiang K, Kandwal A, Loprinzi CL, Mori T, Potting C, Rouleau T, Toro JJ, Ranna V, Vaddi A, Peterson DE, Bossi P, Lalla RV, Elad S (2020) Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 28(5):2449–2456PubMed

11.

Hong CHL, Gueiros LA, Fulton JS, Cheng KKF, Kandwal A, Galiti D et al (2019) Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 27(10):3949–3967PubMed

12.

Logan RM, Al-Azri AR, Bossi P, Stringer AM, Joy JK, Soga Y et al (2020) Systematic review of growth factors and cytokines for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 28(5):2485–2498PubMed

13.

Saunders DP, Rouleau T, Cheng K, Yarom N, Kandwal A, Joy J et al (2020) Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 28(5):2473–2484PubMed

14.

Yarom N, Hovan A, Bossi P, Ariyawardana A, Jensen SB, Gobbo M et al (2020) Systematic review of natural and miscellaneous agents, for the management of oral mucositis in cancer patients and clinical practice guidelines - part 2: honey, herbal compounds, saliva stimulants, probiotics, and miscellaneous agents. Support Care Cancer. 28(5):2457–2472PubMed

15.

Yarom N, Hovan A, Bossi P, Ariyawardana A, Jensen SB, Gobbo M et al (2019) Systematic review of natural and miscellaneous agents for the management of oral mucositis in cancer patients and clinical practice guidelines-part 1: vitamins, minerals, and nutritional supplements. Support Care Cancer. 27(10):3997–4010PubMed

16.

Zadik Y, Arany PR, Fregnani ER, Bossi P, Antunes HS, Bensadoun RJ et al (2019) Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer. 27(10):3969–3983PubMed

17.

Ranna V, Cheng KKF, Castillo DA, Porcello L, Vaddi A, Lalla RV et al (2019) Development of the MASCC/ISOO clinical practice guidelines for mucositis: an overview of the methods. Support Care Cancer. 27(10):3933–3948PubMed

18.

Somerfield MR, McCrae RR (2000) Stress and coping research. Methodological challenges, theoretical advances, and clinical applications. Am Psychol. 55(6):620–625PubMed

19.

Hadorn DC, Baker D, Hodges JS, Hicks N (1996) Rating the quality of evidence for clinical practice guidelines. J Clin Epidemiol. 49(7):749–754PubMed

20.

Rojas de Morales T, Zambrano O, Rivera L, Navas R, Chaparro N, Bernardonni C et al (2001) Oral-disease prevention in children with cancer: testing preventive protocol effectiveness. Med Oral. 6(5):326–334PubMed

21.

Chen CF, Wang RH, Cheng SN, Chang YC (2004) Assessment of chemotherapy-induced oral complications in children with cancer. J Pediatr Oncol Nurs. 21(1):33–39PubMed

22.

Cheng KK, Molassiotis A, Chang AM (2002) An oral care protocol intervention to prevent chemotherapy-induced oral mucositis in paediatric cancer patients: a pilot study. Eur J Oncol Nurs. 6(2):66–73PubMed

23.

Cheng KK, Molassiotis A, Chang AM, Wai WC, Cheung SS (2001) Evaluation of an oral care protocol intervention in the prevention of chemotherapy-induced oral mucositis in paediatric cancer patients. Eur J Cancer. 37(16):2056–2063PubMed

24.

Levy-Polack MP, Sebelli P, Polack NL (1998) Incidence of oral complications and application of a preventive protocol in children with acute leukemia. Spec Care Dentist. 18(5):189–193PubMed

25.

Yavuz B, Bal YH (2015) Investigation of the effects of planned mouth care education on the degree of oral mucositis in pediatric oncology patients. J Pediatr Oncol Nurs. 32(1):47–56PubMed

26.

Cheng KK, Chang AM, Yuen MP (2004) Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care. Eur J Cancer. 40(8):1208–1216PubMed

27.

Costa EM, Fernandes MZ, Quinder LB, de Souza LB, Pinto LP (2003) Evaluation of an oral preventive protocol in children with acute lymphoblastic leukemia. Pesqui Odontol Bras. 17(2):147–150PubMed

28.

Raether D, Walker PO, Bostrum B, Weisdorf D (1989) Effectiveness of oral chlorhexidine for reducing stomatitis in a pediatric bone marrow transplant population. Pediatr Dent. 11(1):37–42PubMed

29.

Cheng KK (2004) Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis. Eur J Oncol Nurs. 8(4):341–349PubMed

30.

Cheng KK, Chang AM (2003) Palliation of oral mucositis symptoms in pediatric patients treated with cancer chemotherapy. Cancer Nurs. 26(6):476–484PubMed

31.

Lever SA, Dupuis LL, Chan HS (1987) Comparative evaluation of benzydamine oral rinse in children with antineoplastic-induced stomatitis. Drug Intell Clin Pharm. 21(4):359–361PubMed

32.

Shenep JL, Kalwinsky DK, Hutson PR, George SL, Dodge RK, Blankenship KR, Thornton D (1988) Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis. J Pediatr. 113(4):758–763PubMed

33.

Bondi E, Baroni C, Prete A, Gatti M, Carrassi A, Lodi G, Porters SR (1997) Local antimicrobial therapy of oral mucositis in paediatric patients undergoing bone marrow transplantation. Oral Oncol. 33(5):322–326PubMed

34.

Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, van de Wetering MD et al (2013) Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer. 21(11):3191–3207PubMed

35.

Collins JJ, Geake J, Grier HE, Houck CS, Thaler HT, Weinstein HJ, Twum-Danso NY, Berde CB (1996) Patient-controlled analgesia for mucositis pain in children: a three-period crossover study comparing morphine and hydromorphone. J Pediatr. 129(5):722–728PubMed

36.

Mackie AM, Coda BC, Hill HF (1991) Adolescents use patient-controlled analgesia effectively for relief from prolonged oropharyngeal mucositis pain. Pain. 46(3):265–269PubMed

37.

James PJ, Howard RF, Williams DG (2010) The addition of ketamine to a morphine nurse- or patient-controlled analgesia infusion (PCA/NCA) increases analgesic efficacy in children with mucositis pain. Paediatr Anaesth. 20(9):805–811PubMed

38.

Lucchese A, Matarese G, Ghislanzoni LH, Gastaldi G, Manuelli M, Gherlone E (2016) Efficacy and effects of palifermin for the treatment of oral mucositis in patients affected by acute lymphoblastic leukemia. Leuk Lymphoma. 57(4):820–827PubMed

39.

Lucchese A, Matarese G, Manuelli M, Ciuffreda C, Bassani L, Isola G, Cordasco G, Gherlone E (2016) Reliability and efficacy of palifermin in prevention and management of oral mucositis in patients with acute lymphoblastic leukemia: a randomized, double-blind controlled clinical trial. Minerva Stomatol. 65(1):43–50PubMed

40.

Morris J, Rudebeck M, Neudorf S, Moore T, Duerst R, Shah AJ, Graham M, Aquino V, Morris C, Olsson B (2016) Safety, pharmacokinetics, and efficacy of palifermin in children and adolescents with acute leukemias undergoing myeloablative therapy and allogeneic hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium trial. Biol Blood Marrow Transplant. 22(7):1247–1256PubMed

41.

Czyzewski K, Debski R, Krenska A, Wysocki M, Styczynski J (2014) Palifermin in children undergoing autologous stem cell transplantation: a matched-pair analysis. Anticancer Res. 34(12):7379–7382PubMed

42.

Lauritano D, Petruzzi M, Di Stasio D, Lucchese A (2014) Clinical effectiveness of palifermin in prevention and treatment of oral mucositis in children with acute lymphoblastic leukaemia: a case-control study. Int J Oral Sci. 6(1):27–30PubMed

43.

Vitale KM, Violago L, Cofnas P, Bishop J, Jin Z, Bhatia M, Kung AL, George D, Garvin J, Satwani P (2014) Impact of palifermin on incidence of oral mucositis and healthcare utilization in children undergoing autologous hematopoietic stem cell transplantation for malignant diseases. Pediatr Transplant. 18(2):211–216PubMed

44.

Patte C, Laplanche A, Bertozzi AI, Baruchel A, Frappaz D, Schmitt C, Mechinaud F, Nelken B, Boutard P, Michon J (2002) Granulocyte colony-stimulating factor in induction treatment of children with non-Hodgkin's lymphoma: a randomized study of the French Society of Pediatric Oncology. J Clin Oncol. 20(2):441–448PubMed

45.

Gordon B, Spadinger A, Hodges E, Ruby E, Stanley R, Coccia P (1994) Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis after hematopoietic stem-cell transplantation. J Clin Oncol. 12(9):1917–1922PubMed

46.

de Koning BA, Philipsen-Geerling B, Hoijer M, Hahlen K, Buller HA, Pieters R (2007) Protection against chemotherapy induced mucositis by TGF-beta(2) in childhood cancer patients: results from a randomized cross-over study. Pediatr Blood Cancer. 48(5):532–539PubMed

47.

Raphael MF, den Boer AM, Kollen WJ, Mekelenkamp H, Abbink FC, Kaspers GJ et al (2014) Caphosol, a therapeutic option in case of cancer therapy-induced oral mucositis in children? : Results from a prospective multicenter double blind randomized controlled trial. Support Care Cancer. 22(1):3–6PubMed

48.

Uderzo C, Rebora P, Marrocco E, Varotto S, Cichello F, Bonetti M, Maximova N, Zanon D, Fagioli F, Nesi F, Masetti R, Rovelli A, Rondelli R, Valsecchi MG, Cesaro S (2011) Glutamine-enriched nutrition does not reduce mucosal morbidity or complications after stem-cell transplantation for childhood malignancies: a prospective randomized study. Transplantation. 91(12):1321–1325PubMed

49.

Kuskonmaz B, Yalcin S, Kucukbayrak O, Cetin N, Cetin M, Tezcan I, Uckan D (2008) The effect of glutamine supplementation on hematopoietic stem cell transplant outcome in children: a case-control study. Pediatr Transplant. 12(1):47–51PubMed

50.

Aquino VM, Harvey AR, Garvin JH, Godder KT, Nieder ML, Adams RH et al (2005) A double-blind randomized placebo-controlled study of oral glutamine in the prevention of mucositis in children undergoing hematopoietic stem cell transplantation: a pediatric blood and marrow transplant consortium study. Bone Marrow Transplant. 36(7):611–616PubMed

51.

Ward E, Smith M, Henderson M, Reid U, Lewis I, Kinsey S, Allgar V, Bowers D, Picton SV (2009) The effect of high-dose enteral glutamine on the incidence and severity of mucositis in paediatric oncology patients. Eur J Clin Nutr. 63(1):134–140PubMed

52.

Yildirim ZK, Bidev D, Buyukavci M (2013) Parenteral glutamine supplementation has no effect on chemotherapy-induced toxicity in children with non-Hodgkin lymphoma. J Pediatr Hematol Oncol. 35(5):371–376PubMed

53.

Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P, Ota S, Feldman BM (2007) Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer. 43(8):1269–1275PubMed

54.

Khurana H, Pandey RK, Saksena AK, Kumar A (2013) An evaluation of vitamin E and pycnogenol in children suffering from oral mucositis during cancer chemotherapy. Oral Dis. 19(5):456–464PubMed

55.

Hamidieh AA, Sherafatmand M, Mansouri A, Hadjibabaie M, Ashouri A, Jahangard-Rafsanjani Z, Gholami K, Javadi MR, Ghavamzadeh A, Radfar M (2016) Calcitriol for oral mucositis prevention in patients with Fanconi anemia undergoing hematopoietic SCT: a double-blind, randomized, placebo-controlled trial. Am J Ther. 23(6):e1700–e17e8PubMed

56.

Abdulrhman M, Elbarbary NS, Ahmed Amin D, Saeid ER (2012) Honey and a mixture of honey, beeswax, and olive oil-propolis extract in treatment of chemotherapy-induced oral mucositis: a randomized controlled pilot study. Pediatr Hematol Oncol. 29(3):285–292PubMed

57.

Tomaževič T, Jazbec J (2013) A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complement Ther Med. 21(4):306–312PubMed

58.

Oberbaum M, Yaniv I, Ben-Gal Y, Stein J, Ben-Zvi N, Freedman LS, Branski D (2001) A randomized, controlled clinical trial of the homeopathic medication TRAUMEEL S in the treatment of chemotherapy-induced stomatitis in children undergoing stem cell transplantation. Cancer. 92(3):684–690PubMed

59.

Sencer SF, Zhou T, Freedman LS, Ives JA, Chen Z, Wall D, Nieder ML, Grupp SA, Yu LC, Sahdev I, Jonas WB, Wallace JD, Oberbaum M (2012) Traumeel S in preventing and treating mucositis in young patients undergoing SCT: a report of the Children's Oncology Group. Bone Marrow Transplant. 47(11):1409–1414PubMedPubMedCentral

60.

Eghbali A, Taherkhanchi B, Bagheri B, Sadeghi SB (2016) Effect of chewing gum on oral mucositis in children undergoing chemotherapy: a randomized controlled study. Iran J Ped Hematol Oncol. 6(1):9–14PubMedPubMedCentral

61.

Gandemer V, Le Deley MC, Dollfus C, Auvrignon A, Bonnaure-Mallet M, Duval M et al (2007) Multicenter randomized trial of chewing gum for preventing oral mucositis in children receiving chemotherapy. J Pediatr Hematol Oncol. 29(2):86–94PubMed

62.

Sato A, Saisho-Hattori T, Koizumi Y, Minegishi M, Iinuma K, Imaizumi M (2006) Prophylaxis of mucosal toxicity by oral propantheline and cryotherapy in children with malignancies undergoing myeloablative chemo-radiotherapy. Tohoku J Exp Med. 210(4):315–320PubMed

63.

Amadori F, Bardellini E, Conti G, Pedrini N, Schumacher RF, Majorana A (2016) Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: a randomized double-blind controlled study. Lasers Med Sci. 31(6):1231–1236PubMed

64.

Chermetz M, Gobbo M, Ronfani L, Ottaviani G, Zanazzo GA, Verzegnassi F, Treister NS, di Lenarda R, Biasotto M, Zacchigna S (2014) Class IV laser therapy as treatment for chemotherapy-induced oral mucositis in onco-haematological paediatric patients: a prospective study. Int J Paediatr Dent. 24(6):441–449PubMed

65.

Whelan HT, Connelly JF, Hodgson BD, Barbeau L, Post AC, Bullard G, Buchmann EV, Kane M, Whelan NT, Warwick A, Margolis D (2002) NASA light-emitting diodes for the prevention of oral mucositis in pediatric bone marrow transplant patients. J Clin Laser Med Surg. 20(6):319–324PubMed

66.

Pytlík R, Benes P, Patorková M, Chocenská E, Gregora E, Procházka B, Kozák T (2002) Standardized parenteral alanyl-glutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant. 30(12):953–961PubMed

67.

Tomlinson D, Gibson F, Treister N, Baggott C, Judd P, Hendershot E, Maloney AM, Doyle J, Feldman B, Kwong K, Sung L (2009) Understandability, content validity, and overall acceptability of the Children's International Mucositis Evaluation Scale (ChIMES): child and parent reporting. J Pediatr Hematol Oncol. 31(6):416–423PubMed

68.

Noirrit-Esclassan E, Valera MC, Vignes E, Munzer C, Bonal S, Daries M, Vaysse F, Puiseux C, Castex MP, Boulanger C, Pasquet M (2019) Photobiomodulation with a combination of two wavelengths in the treatment of oral mucositis in children: The PEDIALASE feasibility study. Arch Pediatr. 26(5):268–274PubMed

69.

Treister NS, London WB, Guo D, Malsch M, Verrill K, Brewer J, Margossian S, Duncan C (2016) A feasibility study evaluating extraoral photobiomodulation therapy for prevention of mucositis in pediatric hematopoietic cell transplantation. Photomed Laser Surg. 34(4):178–184PubMed

70.

Ljungman L, Cernvall M, Ghaderi A, Ljungman G, von Essen L, Ljótsson B (2018) An open trial of individualized face-to-face cognitive behavior therapy for psychological distress in parents of children after end of treatment for childhood cancer including a cognitive behavioral conceptualization. PeerJ. 6:e4570PubMedPubMedCentral

71.

Barros IM, Alcântara TS, Mesquita AR, Santos AC, Paixão FP, Lyra DP Jr (2014) The use of pictograms in the health care: a literature review. Res Social Adm Pharm. 10(5):704–719PubMed

72.

Li WH, Chung JO, Ho EK (2011) The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer. J Clin Nurs. 20(15-16):2135–2143PubMed

73.

Lopes-Junior LC, Silveira DSC, Olson K, Bomfim EO, Veronez LC, Santos JC et al (2019) Clown intervention on psychological stress and fatigue in pediatric patients with cancer undergoing chemotherapy. Cancer Nurs

74.

Silva NB, Osório FL (2018) Impact of an animal-assisted therapy programme on physiological and psychosocial variables of paediatric oncology patients. PLoS One. 13(4):e0194731PubMedPubMedCentral

75.

Lopez-Rodriguez MM, Fernández-Millan A, Ruiz-Fernández MD, Dobarrio-Sanz I, Fernández-Medina IM (2020) New technologies to improve pain, anxiety and depression in children and adolescents with cancer: a systematic review. Int J Environ Res Public Health 17(10)

76.

Konuk Sener D, Aydin M, Cangur S, Guven E (2019) The effect of oral care with Chlorhexidine, vitamin E and honey on mucositis in pediatric intensive care patients: a randomized controlled trial. J Pediatr Nurs. 45:e95–e101PubMed

77.

Alkhouli M, Laflouf M, Alhaddad M (2020) Efficacy of aloe-vera use for prevention of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia: a randomized controlled clinical trial. Compr Child Adolesc Nurs.:1–14

78.

Al Jaouni SK, Al Muhayawi MS, Hussein A, Elfiki I, Al-Raddadi R, Al Muhayawi SM et al (2017) Effects of Honey on oral mucositis among pediatric cancer patients undergoing chemo/radiotherapy treatment at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia. Evid Based Complement Alternat Med 2017:5861024PubMedPubMedCentral

79.

Eslami H, Pouralibaba F, Falsafi P, Bohluli S, Najati B, Negahdari R, Ghanizadeh M (2016) Efficacy of Hypozalix spray and propolis mouthwash for prevention of chemotherapy-induced oral mucositis in leukemic patients: A double-blind randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 10(4):226–233PubMedPubMedCentral

80.

Tavakoli Ardakani M, Ghassemi S, Mehdizadeh M, Mojab F, Salamzadeh J, Ghassemi S, Hajifathali A (2016) Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial. Complement Ther Med. 29:29–34PubMed

81.

Treister N, Nieder M, Baggott C, Olson E, Chen L, Dang H, Krailo M, August A, Sung L (2017) Caphosol for prevention of oral mucositis in pediatric myeloablative haematopoietic cell transplantation. Br J Cancer. 116(1):21–27PubMed

82.

Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F, Majorana A (2016) Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 38(7):559–562PubMed

83.

Gobbo M, Verzegnassi F, Ronfani L, Zanon D, Melchionda F, Bagattoni S, Majorana A, Bardellini E, Mura R, Piras A, Petris MG, Mariuzzi ML, Barone A, Merigo E, Decembrino N, Vitale MC, Berger M, Defabianis P, Biasotto M, Ottaviani G, Zanazzo GA (2018) Multicenter randomized, double-blind controlled trial to evaluate the efficacy of laser therapy for the treatment of severe oral mucositis induced by chemotherapy in children: laMPO RCT. Pediatr Blood Cancer. 65(8):e27098PubMed

84.

Medeiros-Filho JB, Maia Filho EM, Ferreira MC (2017) Laser and photochemotherapy for the treatment of oral mucositis in young patients: Randomized clinical trial. Photodiagnosis Photodyn Ther. 18:39–45PubMed

85.

Ribeiro da Silva VC, da Motta Silveira FM, Barbosa Monteiro MG, da Cruz MMD, Caldas Junior AF, Pina Godoy G. Photodynamic therapy for treatment of oral mucositis: Pilot study with pediatric patients undergoing chemotherapy. Photodiagnosis Photodyn Ther. 2018;21:115-20.

86.

Vitale MC, Modaffari C, Decembrino N, Zhou FX, Zecca M, Defabianis P (2017) Preliminary study in a new protocol for the treatment of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and chemotherapy (CT). Lasers Med Sci. 32(6):1423–1428PubMed

87.

Kamsvåg T, Svanberg A, Legert KG, Arvidson J, von Essen L, Mellgren K et al (2020) Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations-a feasibility study and randomized controlled trial. Support Care Cancer

88.

Tsurusawa M, Watanabe T, Gosho M, Mori T, Mitsui T, Sunami S, Kobayashi R, Fukano R, Tanaka F, Fujita N, Inada H, Sekimizu M, Koh K, Kosaka Y, Komada Y, Saito AM, Nakazawa A, Horibe K, for the lymphoma committee of the Japanese Pediatric Leukemia/lymphoma Study Group (2016) Randomized study of granulocyte colony stimulating factor for childhood B-cell non-Hodgkin lymphoma: a report from the Japanese pediatric leukemia/lymphoma study group B-NHL03 study. Leuk Lymphoma 57(7):1657–1664PubMed

89.

Gholizadeh N, Mehdipoor M, Sajadi H, Moosavi MS (2016) Palifermin and chlorhexidine mouthwashes in prevention of chemotherapy-induced mucositis in children with acute lymphocytic leukemia: a randomized controlled trial. J Dent (Shiraz). 17(4):343–347PubMedCentral

90.

Elad S, Cheng KKF, Lalla RV, Yarom N, Hong C, Logan RM, Bowen J, Gibson R, Saunders DP, Zadik Y, Ariyawardana A, Correa ME, Ranna V, Bossi P; Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) (2020). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. https://doi.org/10.1002/cncr.33100

Titel: MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients
verfasst von: Wanessa Miranda-Silva
Wagner Gomes-Silva
Yehuda Zadik
Noam Yarom
Abdul Rahman Al-Azri
Catherine H. L. Hong
Anura Ariyawardana
Deborah P. Saunders
M. Elvira Correa
Praveen R. Arany
Joanne Bowen
Karis Kin Fong Cheng
Wim J. E. Tissing
Paolo Bossi
Sharon Elad
On behalf of the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO)
Publikationsdatum: 06.11.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 7/2021
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-020-05803-4

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MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients