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01.04.2013 | Original Article

Limaprost alfadex and nonsteroidal anti-inflammatory drugs for sciatica due to lumbar spinal stenosis

verfasst von: Akira Onda, Shin-ichi Kikuchi, Shoji Yabuki, Koji Otani, Takuya Nikaido, Kazuyuki Watanabe, Shin-ichi Konno

Erschienen in: European Spine Journal | Ausgabe 4/2013

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Abstract

Purpose

Limaprost, a prostaglandin E₁ analog, has vasodilatory properties and increases blood flow of the nerve root. However, it has not been clarified whether limaprost affects pain sensation associated with radiculopathy due to lumbar spinal stenosis (LSS). The aim of this study was to compare the efficacy of oral limaprost with nonsteroidal anti-inflammatory drugs (NSAIDs) for radiculopathy.

Methods

We performed a multicenter prospective randomized trial. Patients with LSS who had radicular-type neurologic intermittent claudication assessed based on a self-reported diagnostic support tool were randomized into three treatment groups. Limaprost, NSAIDs, or limaprost plus NSAIDs were administered orally for 6 weeks. Leg pain, low back pain (LBP) and the associated symptoms were assessed by a numerical rating scale (NRS) both at rest and on movement as well as the Roland–Morris Disability Questionnaire (RDQ) and Short Form (SF)-36.

Results

Sixty-one patients were enrolled in the study. Each treatment finally reduced radicular pain, and the improvement was prominent in a combination treatment. There were no significant differences in radicular pain among three groups at final follow-up. LBP was not influenced by limaprost, and a significant reduction of LBP and RDQ was confirmed in a combination treatment compared with limaprost. Physical function of the SF-36 subscales after a combination treatment showed a marked alleviation compared with NSAIDs.

Conclusions

These obtained findings suggest that the effects of limaprost seem to be limited to radicular pain, not for LBP. Overall, a combination treatment might be more effective in the management of radiculopathy induced by LSS than monotherapy with either agent.

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Titel: Limaprost alfadex and nonsteroidal anti-inflammatory drugs for sciatica due to lumbar spinal stenosis
verfasst von: Akira Onda
Shin-ichi Kikuchi
Shoji Yabuki
Koji Otani
Takuya Nikaido
Kazuyuki Watanabe
Shin-ichi Konno
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: European Spine Journal / Ausgabe 4/2013
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-012-2551-1

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Limaprost alfadex and nonsteroidal anti-inflammatory drugs for sciatica due to lumbar spinal stenosis