Skip to main content
Erschienen in: Acta Diabetologica 2/2010

01.06.2010 | Original Article

Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes

verfasst von: Alireza Esteghamati, Armin Rashidi, Omid Khalilzedeh, Haleh Ashraf, Mehrshad Abbasi

Erschienen in: Acta Diabetologica | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

We opted in this study to evaluate the association between metabolic syndrome (MetS) and microalbuminuria in type 2 diabetes. A total of 800 adults (344 males; age 54.8 ± 9.6 years) with type 2 diabetes were studied. MetS was defined by the International Diabetes Federation criteria and microalbuminuria by urinary albumin excretion between 30 and 299 mg/day on at least two of three occasions. Patients with macroalbuminuria and those with poor renal function were not included. Microalbuminuria was present in 237 (29.6%) patients with MetS and increased in prevalence with increasing numbers of metabolic abnormalities (P < 0.001). The normo- and micro-albuminuric groups were not significantly different in age, sex, and renal function. However, MetS was significantly more common among patients with (90.3%) than those without (76.6%) microalbuminuria (P < 0.01). In multivariate regression, MetS was the strongest correlate of microalbuminuria (OR = 3.31, 95% CI = 1.91–5.75; P < 0.01). In conclusion, MetS is independently associated with microalbuminuria in type 2 diabetes.
Literatur
1.
Zurück zum Zitat Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 285:2486–2497 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) JAMA 285:2486–2497
2.
Zurück zum Zitat Kawasaki R, Tielsch JM, Wang JJ et al (2008) The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study. Br J Ophthalmol 92:161–196CrossRefPubMed Kawasaki R, Tielsch JM, Wang JJ et al (2008) The metabolic syndrome and retinal microvascular signs in a Japanese population: the Funagata study. Br J Ophthalmol 92:161–196CrossRefPubMed
3.
Zurück zum Zitat Wong TY, Duncan BB, Golden SH et al (2004) Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study. Invest Ophthalmol Vis Sci 45:2949–2954CrossRefPubMed Wong TY, Duncan BB, Golden SH et al (2004) Associations between the metabolic syndrome and retinal microvascular signs: the atherosclerosis risk in communities study. Invest Ophthalmol Vis Sci 45:2949–2954CrossRefPubMed
4.
Zurück zum Zitat Okpechi IG, Pascoe MD, Swanepoel CR et al (2007) Microalbuminuria and the metabolic syndrome in non-diabetic black Africans. Diabetes Vasc Dis Res 4:365–367CrossRef Okpechi IG, Pascoe MD, Swanepoel CR et al (2007) Microalbuminuria and the metabolic syndrome in non-diabetic black Africans. Diabetes Vasc Dis Res 4:365–367CrossRef
5.
Zurück zum Zitat Lee IT, Lee WJ, Huang CN et al (2007) The association of low-grade inflammation, urinary albumin, and insulin resistance with metabolic syndrome in nondiabetic Taiwanese. Metabolism 56:1708–1713CrossRefPubMed Lee IT, Lee WJ, Huang CN et al (2007) The association of low-grade inflammation, urinary albumin, and insulin resistance with metabolic syndrome in nondiabetic Taiwanese. Metabolism 56:1708–1713CrossRefPubMed
6.
Zurück zum Zitat Lin CC, Liu CS, Li TC et al (2007) Microalbuminuria and the metabolic syndrome and its components in the Chinese population. Eur J Clin Invest 37:783–790CrossRefPubMed Lin CC, Liu CS, Li TC et al (2007) Microalbuminuria and the metabolic syndrome and its components in the Chinese population. Eur J Clin Invest 37:783–790CrossRefPubMed
7.
Zurück zum Zitat Klausen KP, Parving HH, Scharling H et al (2007) The association between metabolic syndrome, microalbuminuria and impaired renal function in the general population: impact on cardiovascular disease and mortality. J Intern Med 262:470–478CrossRefPubMed Klausen KP, Parving HH, Scharling H et al (2007) The association between metabolic syndrome, microalbuminuria and impaired renal function in the general population: impact on cardiovascular disease and mortality. J Intern Med 262:470–478CrossRefPubMed
8.
Zurück zum Zitat Ninomiya T, Kiyohara Y (2007) Albuminuria and chronic kidney disease in association with the metabolic syndrome. J Cardiometab Syndr 2:104–107CrossRefPubMed Ninomiya T, Kiyohara Y (2007) Albuminuria and chronic kidney disease in association with the metabolic syndrome. J Cardiometab Syndr 2:104–107CrossRefPubMed
9.
Zurück zum Zitat Hao Z, Konta T, Takasaki S et al (2007) The association between microalbuminuria and metabolic syndrome in the general population in Japan: the Takahata study. Intern Med 46:341–346CrossRefPubMed Hao Z, Konta T, Takasaki S et al (2007) The association between microalbuminuria and metabolic syndrome in the general population in Japan: the Takahata study. Intern Med 46:341–346CrossRefPubMed
10.
Zurück zum Zitat Choi HS, Ryu SH, Lee KB (2006) The relationship of microalbuminuria with metabolic syndrome. Nephron Clin Pract 104:85–93CrossRef Choi HS, Ryu SH, Lee KB (2006) The relationship of microalbuminuria with metabolic syndrome. Nephron Clin Pract 104:85–93CrossRef
11.
Zurück zum Zitat Bonnet F, Marre M, Halimi JM et al (2006) Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR Study. J Hypertens 24:1157–1163CrossRefPubMed Bonnet F, Marre M, Halimi JM et al (2006) Waist circumference and the metabolic syndrome predict the development of elevated albuminuria in non-diabetic subjects: the DESIR Study. J Hypertens 24:1157–1163CrossRefPubMed
12.
Zurück zum Zitat Palaniappan L, Carnethon M, Fortmann SP (2003) Association between microalbuminuria and the metabolic syndrome: NHANES III. Am J Hypertens 16:952–958CrossRefPubMed Palaniappan L, Carnethon M, Fortmann SP (2003) Association between microalbuminuria and the metabolic syndrome: NHANES III. Am J Hypertens 16:952–958CrossRefPubMed
13.
Zurück zum Zitat Rowley K, O’Dea K, Best JD (2003) Association of albuminuria and the metabolic syndrome. Curr Diabetes Rep 3:80–86CrossRef Rowley K, O’Dea K, Best JD (2003) Association of albuminuria and the metabolic syndrome. Curr Diabetes Rep 3:80–86CrossRef
14.
Zurück zum Zitat Rowley KG, Iser DM, Best JD et al (2000) Albuminuria in Australian Aboriginal people: prevalence and associations with components of the metabolic syndrome. Diabetologia 43:1397–1403CrossRefPubMed Rowley KG, Iser DM, Best JD et al (2000) Albuminuria in Australian Aboriginal people: prevalence and associations with components of the metabolic syndrome. Diabetologia 43:1397–1403CrossRefPubMed
15.
Zurück zum Zitat Jassal SK, Langenberg C, von Mühlen D et al (2008) Usefulness of microalbuminuria versus the metabolic syndrome as a predictor of cardiovascular disease in women and men >40 years of age (from the Rancho Bernardo Study). Am J Cardiol 101:1275–1280CrossRefPubMed Jassal SK, Langenberg C, von Mühlen D et al (2008) Usefulness of microalbuminuria versus the metabolic syndrome as a predictor of cardiovascular disease in women and men >40 years of age (from the Rancho Bernardo Study). Am J Cardiol 101:1275–1280CrossRefPubMed
16.
Zurück zum Zitat Erdmann E (2006) Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes. Int J Cardiol 107:147–153CrossRefPubMed Erdmann E (2006) Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes. Int J Cardiol 107:147–153CrossRefPubMed
17.
Zurück zum Zitat Rossi MC, Nicolucci A, Pellegrini F et al (2008) Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (developing education on microalbuminuria for awareness of renal and cardiovascular risk in diabetes) Study. Nephrol Dial Transpl 23:1278–1284CrossRef Rossi MC, Nicolucci A, Pellegrini F et al (2008) Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (developing education on microalbuminuria for awareness of renal and cardiovascular risk in diabetes) Study. Nephrol Dial Transpl 23:1278–1284CrossRef
18.
Zurück zum Zitat Lee IT, Huang CN, Lee WJ et al (2008) Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects. Diabetes Res Clin Pract 81:345–350CrossRefPubMed Lee IT, Huang CN, Lee WJ et al (2008) Aggravation of albuminuria by metabolic syndrome in type 2 diabetic Asian subjects. Diabetes Res Clin Pract 81:345–350CrossRefPubMed
19.
Zurück zum Zitat Hanai K, Babazono T, Iwamoto Y (2008) Renal manifestations of metabolic syndrome in type 2 diabetes. Diabetes Res Clin Pract 79:318–324CrossRefPubMed Hanai K, Babazono T, Iwamoto Y (2008) Renal manifestations of metabolic syndrome in type 2 diabetes. Diabetes Res Clin Pract 79:318–324CrossRefPubMed
20.
Zurück zum Zitat Abdul-Ghani M, Nawaf G, Nawaf F et al (2006) Increased prevalence of microvascular complications in type 2 diabetes patients with the metabolic syndrome. Isr Med Assoc J 8:378–382PubMed Abdul-Ghani M, Nawaf G, Nawaf F et al (2006) Increased prevalence of microvascular complications in type 2 diabetes patients with the metabolic syndrome. Isr Med Assoc J 8:378–382PubMed
21.
Zurück zum Zitat Bianchi C, Penno G, Daniele G et al (2008) The metabolic syndrome is related to albuminuria in type 2 diabetes. Diabet Med 25:1412–1418CrossRefPubMed Bianchi C, Penno G, Daniele G et al (2008) The metabolic syndrome is related to albuminuria in type 2 diabetes. Diabet Med 25:1412–1418CrossRefPubMed
22.
Zurück zum Zitat Isomaa B, Henricsson M, Almgren P et al (2001) The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes. Diabetologia 44:1148–1154CrossRefPubMed Isomaa B, Henricsson M, Almgren P et al (2001) The metabolic syndrome influences the risk of chronic complications in patients with type II diabetes. Diabetologia 44:1148–1154CrossRefPubMed
23.
Zurück zum Zitat Aekplakorn W, Srivanichakorn S, Sangwatanaroj S (2009) Microalbuminuria and metabolic risk factors in patients with type 2 diabetes in primary care setting in Thailand. Diabetes Res Clin Pract 84:92–98CrossRefPubMed Aekplakorn W, Srivanichakorn S, Sangwatanaroj S (2009) Microalbuminuria and metabolic risk factors in patients with type 2 diabetes in primary care setting in Thailand. Diabetes Res Clin Pract 84:92–98CrossRefPubMed
24.
Zurück zum Zitat Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome—a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23:469–480CrossRefPubMed Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome—a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23:469–480CrossRefPubMed
25.
Zurück zum Zitat Esteghamati A, Ashraf H, Rashidi A et al (2008) Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults. Diabetes Res Clin Pract 82:104–107CrossRefPubMed Esteghamati A, Ashraf H, Rashidi A et al (2008) Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults. Diabetes Res Clin Pract 82:104–107CrossRefPubMed
27.
Zurück zum Zitat Levey AS, Bosch JP, Lewis JB et al (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470PubMed Levey AS, Bosch JP, Lewis JB et al (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461–470PubMed
28.
Zurück zum Zitat Watanabe N, Kamei S, Yamanaka M et al (1986) Urinary protein as measures with a pyrogallol red molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem 32:1551–1554PubMed Watanabe N, Kamei S, Yamanaka M et al (1986) Urinary protein as measures with a pyrogallol red molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem 32:1551–1554PubMed
29.
Zurück zum Zitat Genuth S, Alberti KG, Bennett P et al (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRefPubMed Genuth S, Alberti KG, Bennett P et al (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167CrossRefPubMed
30.
Zurück zum Zitat Retnakaran R, Cull CA, Thorne KI et al (2006) Risk factors for renal dysfunction in type 2 diabetes: U.K. prospective diabetes study 74. Diabetes 55:1832–1839CrossRefPubMed Retnakaran R, Cull CA, Thorne KI et al (2006) Risk factors for renal dysfunction in type 2 diabetes: U.K. prospective diabetes study 74. Diabetes 55:1832–1839CrossRefPubMed
31.
Zurück zum Zitat Ravid M, Brosh D, Ravid-Safran D et al (1998) Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch Intern Med 158:998–1004CrossRefPubMed Ravid M, Brosh D, Ravid-Safran D et al (1998) Main risk factors for nephropathy in type 2 diabetes mellitus are plasma cholesterol levels, mean blood pressure, and hyperglycemia. Arch Intern Med 158:998–1004CrossRefPubMed
32.
Zurück zum Zitat Park JY, Kim HK, Chung YE et al (1998) Incidence and determinants of microalbuminuria in Koreans with type 2 diabetes. Diabetes Care 21:530–534CrossRefPubMed Park JY, Kim HK, Chung YE et al (1998) Incidence and determinants of microalbuminuria in Koreans with type 2 diabetes. Diabetes Care 21:530–534CrossRefPubMed
33.
Zurück zum Zitat Barış N, Erdoğan M, Sezer E et al (2009) Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria. Acta Diabetol (in press) Barış N, Erdoğan M, Sezer E et al (2009) Alterations in l-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria. Acta Diabetol (in press)
34.
Zurück zum Zitat Weitzman S, Maislos M, Bodner-Fishman B et al (1997) Association of diabetic retinopathy, ischemic heart disease, and albuminuria with diabetic treatment in type 2 diabetic patients. A population-based study. Acta Diabetol 34:275–279CrossRefPubMed Weitzman S, Maislos M, Bodner-Fishman B et al (1997) Association of diabetic retinopathy, ischemic heart disease, and albuminuria with diabetic treatment in type 2 diabetic patients. A population-based study. Acta Diabetol 34:275–279CrossRefPubMed
35.
Zurück zum Zitat Esteghamati A, Ashraf H, Nakhjavani M et al (2009) Insulin resistance is an independent correlate of increased urine albumin excretion: a cross-sectional study in Iranian type 2 diabetic patients. Diabet Med 26:177–181CrossRefPubMed Esteghamati A, Ashraf H, Nakhjavani M et al (2009) Insulin resistance is an independent correlate of increased urine albumin excretion: a cross-sectional study in Iranian type 2 diabetic patients. Diabet Med 26:177–181CrossRefPubMed
36.
Zurück zum Zitat Arcaro G, Cretti A, Balzano S et al (2002) Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 105:576–582CrossRefPubMed Arcaro G, Cretti A, Balzano S et al (2002) Insulin causes endothelial dysfunction in humans: sites and mechanisms. Circulation 105:576–582CrossRefPubMed
37.
Zurück zum Zitat Resnick LM (1989) Hypertension and abnormal glucose homeostasis. Possible role of divalent ion metabolism. Am J Med 87:17–22CrossRef Resnick LM (1989) Hypertension and abnormal glucose homeostasis. Possible role of divalent ion metabolism. Am J Med 87:17–22CrossRef
38.
Zurück zum Zitat Ewald B, Attia J (2004) Which test to detect microalbuminuria in diabetic patients? A systematic review. Aust Fam Physician 33:565–567PubMed Ewald B, Attia J (2004) Which test to detect microalbuminuria in diabetic patients? A systematic review. Aust Fam Physician 33:565–567PubMed
39.
Zurück zum Zitat Vilarrasa N, Soler J, Montanya E (2005) Regression of microalbuminuria in type 1 diabetic patients: results of a sequential intervention with improved metabolic control and ACE inhibitors. Acta Diabetol 42:87–94CrossRefPubMed Vilarrasa N, Soler J, Montanya E (2005) Regression of microalbuminuria in type 1 diabetic patients: results of a sequential intervention with improved metabolic control and ACE inhibitors. Acta Diabetol 42:87–94CrossRefPubMed
Metadaten
Titel
Metabolic syndrome is independently associated with microalbuminuria in type 2 diabetes
verfasst von
Alireza Esteghamati
Armin Rashidi
Omid Khalilzedeh
Haleh Ashraf
Mehrshad Abbasi
Publikationsdatum
01.06.2010
Verlag
Springer Milan
Erschienen in
Acta Diabetologica / Ausgabe 2/2010
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI
https://doi.org/10.1007/s00592-009-0131-6

Weitere Artikel der Ausgabe 2/2010

Acta Diabetologica 2/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Erhöhte Mortalität bei postpartalem Brustkrebs

07.05.2024 Mammakarzinom Nachrichten

Auch für Trägerinnen von BRCA-Varianten gilt: Erkranken sie fünf bis zehn Jahre nach der letzten Schwangerschaft an Brustkrebs, ist das Sterberisiko besonders hoch.

Hypertherme Chemotherapie bietet Chance auf Blasenerhalt

07.05.2024 Harnblasenkarzinom Nachrichten

Eine hypertherme intravesikale Chemotherapie mit Mitomycin kann für Patienten mit hochriskantem nicht muskelinvasivem Blasenkrebs eine Alternative zur radikalen Zystektomie darstellen. Kölner Urologen berichten über ihre Erfahrungen.

Vorhofflimmern bei Jüngeren gefährlicher als gedacht

06.05.2024 Vorhofflimmern Nachrichten

Immer mehr jüngere Menschen leiden unter Vorhofflimmern. Betroffene unter 65 Jahren haben viele Risikofaktoren und ein signifikant erhöhtes Sterberisiko verglichen mit Gleichaltrigen ohne die Erkrankung.

Chronisches Koronarsyndrom: Gefahr von Hospitalisierung wegen Herzinsuffizienz

06.05.2024 Herzinsuffizienz Nachrichten

Obwohl ein rezidivierender Herzinfarkt bei chronischem Koronarsyndrom wahrscheinlich die Hauptsorge sowohl der Patienten als auch der Ärzte ist, sind andere Ereignisse womöglich gefährlicher. Laut einer französischen Studie stellt eine Hospitalisation wegen Herzinsuffizienz eine größere Gefahr dar.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.