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01.02.2012 | Original Article

The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus

verfasst von: Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Yasutomo Fujii, Kei Konno, Shun Ishibashi, Nobuyuki Taniguchi

Erschienen in: Acta Diabetologica | Ausgabe 1/2012

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Abstract

The clinical significance of the diameter of the common carotid artery (CCA) measured ultrasonographically in diabetic practice has not been sufficiently established. The objective of this study was to investigate the relationship of the ultrasonic CCA diameter with atherosclerotic measures and diabetic retinopathy as a microvascular complication in patients with type 2 diabetes mellitus (T2DM). This hospital-based cross-sectional study included 102 patients with T2DM (men: 65%, mean age: 57 years) who had no apparent carotid arterial stenosis and no history of cardiovascular or severe renal disease. The current smoking status, body mass index, blood pressure, hemoglobin A1c, serum low-density lipoprotein cholesterol, and ultrasonic measures of carotid arteries (CCA diameter, intima-media thickness (IMT), plaque score) were measured. The cardio-ankle vascular index (CAVI) and the presence of diabetic retinopathy were also assessed. The CCA diameter showed a significant positive correlation with the mean IMT or plaque score. The CAVI had a significant positive correlation with the mean IMT, plaque score, and CCA diameter, while diabetic retinopathy had a significant positive correlation with the CCA diameter, but not the mean IMT or plaque score. These results were unaltered after adjusting for multiple confounders. The CCA diameter may serve as a useful marker for atherosclerosis and diabetic retinopathy, and in particular, may be a marker associated with diabetic retinopathy more clearly than the carotid IMT and plaque score, in patients with T2DM.

Salonen JT, Salonen R (1991) Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb 11:1245–1249PubMedCrossRef

O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med 340:14–22PubMedCrossRef

Mannami T, Konishi M, Baba S, Nishi N, Terao A (1997) Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: the Suita study. Stroke 28:518–525PubMedCrossRef

Handa N, Matsumoto M, Maeda H, Hougaku H, Ogawa S, Fukunaga R, Yoneda S, Kimura K, Kamada T (1990) Ultrasonic evaluation of early carotid atherosclerosis. Stroke 21:1567–1572PubMedCrossRef

Park JS, Cho MH, Nam JS, Ahn CW, Cha BS, Lee EJ, Lim SK, Kim KR, Lee HC (2010) Visceral adiposity and leptin are independently associated with C-reactive protein in Korean type 2 diabetic patients. Acta Diabetol 47:113–1181PubMedCrossRef

Wu W, Wang M, Sun Z, Wang X, Miao J, Zheng Z (2010) The predictive value of TNF-alpha and IL-6 and the incidence of macrovascular complications in patients with type 2 diabetes. Acta Diabetol [Epub ahead of print]

Sugawara J, Otsuki T, Maeda S, Tanabe T, Kuno S, Ajisaka R, Matsuda M (2005) Effect of arterial lumen enlargement on carotid arterial compliance in normotensive postmenopausal women. Hypertens Res 28:323–329PubMedCrossRef

Kawamoto R, Tomita H, Oka Y, Ohtsuka N (2006) Association between risk factors and carotid enlargement. Intern Med 45:503–509PubMedCrossRef

Eigenbrodt ML, Bursac Z, Tracy RE, Mehta JL, Rose KM, Couper DJ (2008) B-mode ultrasound common carotid artery intima-media thickness and external diameter: cross-sectional and longitudinal associations with carotid atherosclerosis in a large population sample. Cardiovasc Ultrasound 6:10PubMedCrossRef

10.

Yamasaki Y, Kawamori R, Matsushima H, Nishizawa H, Kodama M, Kajimoto Y, Morishima T, Kamada T (1994) Atherosclerosis in carotid artery of young IDDM patients monitored by ultrasound high-resolution B-mode imaging. Diabetes 43:634–639PubMedCrossRef

11.

Stratton IM, Kohner EM, Aldington SJ, Turner RC, Holman RR, Manley SE, Matthews DR (2001) UKPDS 50: risk factors for incidence and progression of retinopathy in Type II diabetes over 6 years from diagnosis. Diabetologia 44:156–163PubMedCrossRef

12.

Osborne NN, Casson RJ, Wood JP, Chidlow G, Graham M, Melena J (2004) Retinal ischemia: mechanisms of damage and potential therapeutic strategies. Prog Retin Eye Res 23:91–147PubMedCrossRef

13.

Malecki MT, Osmenda G, Walus-Miarka M, Skupien J, Cyganek K, Mirkiewicz-Sieradzka B, damek-Guzik TA, Guzik TJ, Sieradzki J (2008) Retinopathy in type 2 diabetes mellitus is associated with increased intima-media thickness and endothelial dysfunction. Eur J Clin Invest 38:925–930PubMedCrossRef

14.

Rema M, Mohan V, Deepa R, Ravikumar R, Chennai Urban Rural Epidemiology Study-2 (2004) Association of carotid intima-media thickness and arterial stiffness with diabetic retinopathy: the Chennai urban rural epidemiology study (CURES-2). Diabetes Care 27:1962–1967PubMedCrossRef

15.

Ogawa Y, Uchigata Y, Iwamoto Y (2009) Progression factors of carotid intima-media thickness and plaque in patients with long-term, early-onset type 1 diabetes mellitus in Japan: simultaneous comparison with diabetic retinopathy. J Atheroscler Thromb 16:821–828PubMedCrossRef

16.

Shirai K, Utino J, Otsuka K, Takata M (2006) A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb 13:101–107PubMedCrossRef

17.

World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. World Health Organization, Geneva

18.

American Diabetes Association (2008) Diagnosis and classification of diabetes mellitus. Diabetes Care 31:S55–S60CrossRef

19.

North American Symptomatic Carotid Endarterectomy Trial Collaborators (1991) Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 325:445–453CrossRef

20.

Koga M, Kimura K, Minematsu K, Yamaguchi T (2001) Diagnosis of internal carotid artery stenosis greater than 70% with power Doppler duplex sonography. AJNR Am J Neuroradiol 22:413–417PubMed

21.

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A, Collaborators developing the Japanese equation for estimated GFR (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 53:982–992PubMedCrossRef

22.

Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, Dills D, Kampik A, Pararajasegaram R, Verdaguer JT, Global diabetic retinopathy project group (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110:1677–1682PubMedCrossRef

23.

The Committee of Japan Diabetes Society on the diagnostic criteria of diabetes mellitus (2010) Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Jpn Diabetes Soc 53:450–467

24.

Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 25:359–364PubMedCrossRef

25.

Kotani K, Miyamoto M, Taniguchi N (2010) Clinical significance of the cadio-ankle vascular index (CAVI) in hypertension. Curr Hypertens Rev 6:251–253CrossRef

26.

Yamashina A, Tomiyama H, Arai T, Koji Y, Yambe M, Motobe H, Glunizia Z, Yamamoto Y, Hori S (2003) Nomogram of the relation of brachial-ankle pulse wave velocity with blood pressure. Hypertens Res 26:801–806PubMedCrossRef

27.

Okura T, Watanabe S, Kurata M, Manabe S, Koresawa M, Irita J, Enomoto D, Miyoshi K, Fukuoka T, Higaki J (2007) Relationship between cardio-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension. Hypertens Res 30:335–340PubMedCrossRef

28.

Kitaoka M, Matsuo H, Taniguchi N, Ozaki T, Kaneda S, Ennda E, Nagatsuka K, Harada R, Hirai T, Fushimi E, Yasaka M (2009) Standard method for ultrasound evaluation of carotid artery lesions. Jpn J Med Ultrason 36:501–518

29.

Mannami T, Baba S, Ogata J (2000) Potential of carotid enlargement as a useful indicator affected by high blood pressure in a large general population of a Japanese city: the Suita study. Stroke 31:2958–2965PubMedCrossRef

30.

Bots ML, Hofman A, de Bruyn AM, de Jong PT, Grobbee DE (1993) Isolated systolic hypertension and vessel wall thickness of the carotid artery. The Rotterdam elderly study. Arterioscler Thromb 13:64–69PubMedCrossRef

31.

Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316:1371–1375PubMedCrossRef

32.

Menghini R, Marchetti V, Cardellini M, Hribal ML, Mauriello A, Lauro D, Sbraccia P, Lauro R, Federici M (2005) Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 111:1946–1953PubMedCrossRef

33.

Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH (2007) Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 49:2379–2393PubMedCrossRef

34.

Boyajian RA, Otis SM (2004) Relationship of lumen diameter to type and degree of arterial remodeling at sites of expanding wall or plaque thickness in human carotid artery. Cerebrovasc Dis 17:228–237PubMedCrossRef

35.

Terry JG, Tang R, Espeland MA, Davis DH, Vieira JL, Mercuri MF, Crouse JR 3rd (2003) Carotid arterial structure in patients with documented coronary artery disease and disease-free control subjects. Circulation 107:1146–1151PubMedCrossRef

36.

Bots ML, Grobbee DE, Hofman A, Witteman JC (2005) Common carotid intima-media thickness and risk of acute myocardial infarction: the role of lumen diameter. Stroke 36:762–767PubMedCrossRef

Titel: The correlation of common carotid arterial diameter with atherosclerosis and diabetic retinopathy in patients with type 2 diabetes mellitus
verfasst von: Michiaki Miyamoto
Kazuhiko Kotani
Kenta Okada
Yasutomo Fujii
Kei Konno
Shun Ishibashi
Nobuyuki Taniguchi
Publikationsdatum: 01.02.2012
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 1/2012
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-011-0287-8

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