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Acta Neurochirurgica

Erschienen in:

01.02.2012 | Review Article

Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding

verfasst von: Alan Siu, Joshua J. Wind, J. Bryan Iorgulescu, Timothy A. Chan, Yoshiya Yamada, Jonathan H. Sherman

Erschienen in: Acta Neurochirurgica | Ausgabe 2/2012

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Abstract

Radiation therapy is an integral part of the standard treatment paradigm for malignant gliomas, with proven efficacy in randomized control trials. Radiation treatment is not without risk however, and radiation injury occurs in a certain proportion of patients. Difficulties in differentiating recurrence from radiation injury complicate the treatment course and can compromise care. These complexities are compounded by the recent distinction of two types of radiation injury: pseudoprogression and radiation necrosis, which are likely the result of radiation injury to the tumor and normal tissue, respectively. A thorough understanding of radiation-induced injury offers insights to guide further therapies. We detail the current knowledge of the mechanisms of radiation injury, along with potential targets for therapeutic intervention. Various diagnostic modalities are also described, in addition to the multiple options for treatment within the context of their pathophysiology and clinical efficacy. Radiation therapy is an integral part of the multidisciplinary management of gliomas, and the optimal diagnosis and management of radiation injury is paramount to improving patient outcomes.

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Titel: Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding
verfasst von: Alan Siu
Joshua J. Wind
J. Bryan Iorgulescu
Timothy A. Chan
Yoshiya Yamada
Jonathan H. Sherman
Publikationsdatum: 01.02.2012
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 2/2012
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-011-1228-6

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Radiation necrosis following treatment of high grade glioma—a review of the literature and current understanding

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