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Erschienen in: Acta Neurochirurgica 4/2013

01.04.2013 | Clinical Article - Vascular

The combined use of mechanical thrombectomy devices is feasible for treating acute carotid terminus occlusion

verfasst von: Jin Soo Lee, Ji Man Hong, Seong-Joon Lee, In Soo Joo, Yong Cheol Lim, Sun Yong Kim

Erschienen in: Acta Neurochirurgica | Ausgabe 4/2013

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Abstract

Background

Mechanical thrombectomy devices have recently been developed and approved for recanalization of intracranial arterial occlusion. Here, we investigated the feasibility of combined stent-assisted and clot aspiration mechanical thrombectomy for effective recanalization of acute carotid terminus occlusion (CTO).

Methods

Ten consecutive patients with acute ischemic stroke secondary to CTO who underwent intra-arterial (IA) treatment with both stent retrieval and negative-pressured clot aspiration systems were enrolled. Periprocedural and radiologic findings and clinical outcomes were evaluated.

Results

The median age was 69 years (range, 47–86 years), and the median initial NIHSS score was 17.5 (range, 12–33). Mechanical thrombectomy was performed using a combination of the Solitaire stents and Penumbra system. Thrombolysis in cerebral ischemia [TICI] grade II–III was achieved in eight patients (80.0 %); complete recanalization of the CTO (TICI III) was achieved in three of those patients. Any type of intracranial hemorrhages occurred in four patients (40.0 %), but parenchymal hematoma type 2 was not observed. Four patients died within 3 months (40.0 %).

Conclusions

Combined mechanical thrombectomy treatment was effective for recanalization of acute CTO. The combination of Solitaire and Penumbra devices can be considered as a treatment option for CTO.
Literatur
1.
Zurück zum Zitat Arnold M (2003) Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatry 74:739–742PubMedCrossRef Arnold M (2003) Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions. J Neurol Neurosurg Psychiatry 74:739–742PubMedCrossRef
2.
Zurück zum Zitat Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, Branca V, Sit SP, Penumbra Phase 1 Stroke Trial Investigators (2008) The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol 29:1409–1413PubMedCrossRef Bose A, Henkes H, Alfke K, Reith W, Mayer TE, Berlis A, Branca V, Sit SP, Penumbra Phase 1 Stroke Trial Investigators (2008) The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol 29:1409–1413PubMedCrossRef
3.
Zurück zum Zitat Castano C, Dorado L, Guerrero C, Millan M, Gomis M, Perez de la Ossa N, Castellanos M, Garcia MR, Domenech S, Davalos A (2010) Mechanical thrombectomy with the Solitaire AB device in large artery occlusions of the anterior circulation: a pilot study. Stroke 41:1836–1840PubMedCrossRef Castano C, Dorado L, Guerrero C, Millan M, Gomis M, Perez de la Ossa N, Castellanos M, Garcia MR, Domenech S, Davalos A (2010) Mechanical thrombectomy with the Solitaire AB device in large artery occlusions of the anterior circulation: a pilot study. Stroke 41:1836–1840PubMedCrossRef
4.
Zurück zum Zitat Costalat V, Machi P, Lobotesis K, Maldonado I, Vendrell JF, Riquelme C, Mourand I, Milhaud D, Heroum C, Perrigault PF, Arquizan C, Bonafe A (2011) Rescue, combined, and stand-alone thrombectomy in the management of large vessel occlusion stroke using the solitaire device: a prospective 50-patient single-center study: timing, safety, and efficacy. Stroke 42:1929–1935PubMedCrossRef Costalat V, Machi P, Lobotesis K, Maldonado I, Vendrell JF, Riquelme C, Mourand I, Milhaud D, Heroum C, Perrigault PF, Arquizan C, Bonafe A (2011) Rescue, combined, and stand-alone thrombectomy in the management of large vessel occlusion stroke using the solitaire device: a prospective 50-patient single-center study: timing, safety, and efficacy. Stroke 42:1929–1935PubMedCrossRef
5.
Zurück zum Zitat Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA 282:2003–2011PubMedCrossRef Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Silver F, Rivera F (1999) Intra-arterial prourokinase for acute ischemic stroke. The PROACT II Study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA 282:2003–2011PubMedCrossRef
6.
Zurück zum Zitat Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH, Hennerici M (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017–1025PubMedCrossRef Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R, Boysen G, Bluhmki E, Hoxter G, Mahagne MH, Hennerici M (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017–1025PubMedCrossRef
7.
Zurück zum Zitat Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D (2003) Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 34:e109–e137PubMedCrossRef Higashida RT, Furlan AJ, Roberts H, Tomsick T, Connors B, Barr J, Dillon W, Warach S, Broderick J, Tilley B, Sacks D (2003) Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 34:e109–e137PubMedCrossRef
8.
Zurück zum Zitat IMS II Trial Investigators (2007) The Interventional Management of Stroke (IMS) II Study. Stroke 38:2127–2135CrossRef IMS II Trial Investigators (2007) The Interventional Management of Stroke (IMS) II Study. Stroke 38:2127–2135CrossRef
9.
Zurück zum Zitat IMS Study Investigators (2004) Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 35:904–911CrossRef IMS Study Investigators (2004) Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 35:904–911CrossRef
10.
Zurück zum Zitat Jansen O, von Kummer R, Forsting M, Hacke W, Sartor K (1995) Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol 16:1977–1986PubMed Jansen O, von Kummer R, Forsting M, Hacke W, Sartor K (1995) Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol 16:1977–1986PubMed
11.
Zurück zum Zitat Kang DH, Hwang YH, Kim YS, Park J, Kwon O, Jung C (2011) Direct thrombus retrieval using the reperfusion catheter of the Penumbra system: forced-suction thrombectomy in acute ischemic stroke. AJNR Am J Neuroradiol 32:283–287PubMedCrossRef Kang DH, Hwang YH, Kim YS, Park J, Kwon O, Jung C (2011) Direct thrombus retrieval using the reperfusion catheter of the Penumbra system: forced-suction thrombectomy in acute ischemic stroke. AJNR Am J Neuroradiol 32:283–287PubMedCrossRef
12.
Zurück zum Zitat Kulcsar Z, Bonvin C, Pereira VM, Altrichter S, Yilmaz H, Lovblad KO, Sztajzel R, Rufenacht DA (2010) Penumbra system: a novel mechanical thrombectomy device for large-vessel occlusions in acute stroke. AJNR Am J Neuroradiol 31:628–633PubMedCrossRef Kulcsar Z, Bonvin C, Pereira VM, Altrichter S, Yilmaz H, Lovblad KO, Sztajzel R, Rufenacht DA (2010) Penumbra system: a novel mechanical thrombectomy device for large-vessel occlusions in acute stroke. AJNR Am J Neuroradiol 31:628–633PubMedCrossRef
13.
Zurück zum Zitat Lee JS, Hong JM, Kim EJ, Shin DH, Joo IS, Lim YC, Suh SH, Kim SY (2012) Comparison of the incidence of parenchymal hematoma and poor outcome in patients with carotid terminus occlusion treated with intra-arterial urokinase alone or with combined IV rtPA and intra-arterial urokinase. AJNR Am J Neuroradiol 33:175–179PubMedCrossRef Lee JS, Hong JM, Kim EJ, Shin DH, Joo IS, Lim YC, Suh SH, Kim SY (2012) Comparison of the incidence of parenchymal hematoma and poor outcome in patients with carotid terminus occlusion treated with intra-arterial urokinase alone or with combined IV rtPA and intra-arterial urokinase. AJNR Am J Neuroradiol 33:175–179PubMedCrossRef
14.
Zurück zum Zitat Lee KY, Kim DI, Kim SH, Lee SI, Chung HW, Shim YW, Kim SM, Heo JH (2004) Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. AJNR Am J Neuroradiol 25:1470–1475PubMed Lee KY, Kim DI, Kim SH, Lee SI, Chung HW, Shim YW, Kim SM, Heo JH (2004) Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. AJNR Am J Neuroradiol 25:1470–1475PubMed
15.
Zurück zum Zitat Lewandowski CA, Frankel M, Tomsick TA, Broderick J, Frey J, Clark W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T (1999) Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30:2598–2605PubMedCrossRef Lewandowski CA, Frankel M, Tomsick TA, Broderick J, Frey J, Clark W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T (1999) Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30:2598–2605PubMedCrossRef
16.
Zurück zum Zitat Menon BK, Hill MD, Eesa M, Modi J, Bhatia R, Wong J, Hudon ME, Morrish W, Demchuk AM, Goyal M (2011) Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke. Neuroradiology 53:261–266PubMedCrossRef Menon BK, Hill MD, Eesa M, Modi J, Bhatia R, Wong J, Hudon ME, Morrish W, Demchuk AM, Goyal M (2011) Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke. Neuroradiology 53:261–266PubMedCrossRef
17.
Zurück zum Zitat Miteff F, Faulder KC, Goh AC, Steinfort BS, Sue C, Harrington TJ (2011) Mechanical thrombectomy with a self-expanding retrievable intracranial stent (Solitaire AB): experience in 26 patients with acute cerebral artery occlusion. AJNR Am J Neuroradiol 32:1078–1081PubMedCrossRef Miteff F, Faulder KC, Goh AC, Steinfort BS, Sue C, Harrington TJ (2011) Mechanical thrombectomy with a self-expanding retrievable intracranial stent (Solitaire AB): experience in 26 patients with acute cerebral artery occlusion. AJNR Am J Neuroradiol 32:1078–1081PubMedCrossRef
18.
Zurück zum Zitat Nogueira RG, Lutsep HL, Gupta R, Jovin TG, Albers GW, Walker GA, Liebeskind DS, Smith WS (2012) Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet 380:1231–1240PubMedCrossRef Nogueira RG, Lutsep HL, Gupta R, Jovin TG, Albers GW, Walker GA, Liebeskind DS, Smith WS (2012) Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet 380:1231–1240PubMedCrossRef
19.
Zurück zum Zitat Park H, Hwang GJ, Jin SC, Jung CK, Bang JS, Han MK, Bae HJ, Choe GY, Oh CW, Kwon OK (2011) A retrieval thrombectomy technique with the Solitaire stent in a large cerebral artery occlusion. Acta Neurochir 153:1625–1631PubMedCrossRef Park H, Hwang GJ, Jin SC, Jung CK, Bang JS, Han MK, Bae HJ, Choe GY, Oh CW, Kwon OK (2011) A retrieval thrombectomy technique with the Solitaire stent in a large cerebral artery occlusion. Acta Neurochir 153:1625–1631PubMedCrossRef
20.
Zurück zum Zitat Penumbra Pivotal Stroke Trial Investigators (2009) The Penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 40:2761–2768CrossRef Penumbra Pivotal Stroke Trial Investigators (2009) The Penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke 40:2761–2768CrossRef
21.
Zurück zum Zitat Pexman JH, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon ME, Hu WY, Buchan AM (2001) Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol 22:1534–1542PubMed Pexman JH, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon ME, Hu WY, Buchan AM (2001) Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol 22:1534–1542PubMed
22.
Zurück zum Zitat Rha JH, Saver JL (2007) The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 38:967–973PubMedCrossRef Rha JH, Saver JL (2007) The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 38:967–973PubMedCrossRef
23.
Zurück zum Zitat Roth C, Papanagiotou P, Behnke S, Walter S, Haass A, Becker C, Fassbender K, Politi M, Korner H, Romann MS, Reith W (2010) Stent-assisted mechanical recanalization for treatment of acute intracerebral artery occlusions. Stroke 41:2559–2567PubMedCrossRef Roth C, Papanagiotou P, Behnke S, Walter S, Haass A, Becker C, Fassbender K, Politi M, Korner H, Romann MS, Reith W (2010) Stent-assisted mechanical recanalization for treatment of acute intracerebral artery occlusions. Stroke 41:2559–2567PubMedCrossRef
24.
Zurück zum Zitat Saver JL, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO (2012) Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 380:1241–1249PubMedCrossRef Saver JL, Jahan R, Levy EI, Jovin TG, Baxter B, Nogueira RG, Clark W, Budzik R, Zaidat OO (2012) Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet 380:1241–1249PubMedCrossRef
25.
Zurück zum Zitat Tomsick T, Broderick J, Carrozella J, Khatri P, Hill M, Palesch Y, Khoury J (2008) Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol 29:582–587PubMedCrossRef Tomsick T, Broderick J, Carrozella J, Khatri P, Hill M, Palesch Y, Khoury J (2008) Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol 29:582–587PubMedCrossRef
26.
Zurück zum Zitat Urbach H, Ries F, Ostertun B, Solymosi L (1997) Local intra-arterial fibrinolysis in thromboembolic “T” occlusions of the internal carotid artery. Neuroradiology 39:105–110PubMedCrossRef Urbach H, Ries F, Ostertun B, Solymosi L (1997) Local intra-arterial fibrinolysis in thromboembolic “T” occlusions of the internal carotid artery. Neuroradiology 39:105–110PubMedCrossRef
27.
Zurück zum Zitat Wolpert SM, Bruckmann H, Greenlee R, Wechsler L, Pessin MS, del Zoppo GJ (1993) Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group. AJNR Am J Neuroradiol 14:3–13PubMed Wolpert SM, Bruckmann H, Greenlee R, Wechsler L, Pessin MS, del Zoppo GJ (1993) Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group. AJNR Am J Neuroradiol 14:3–13PubMed
28.
Zurück zum Zitat Zaidat OO, Suarez JI, Santillan C, Sunshine JL, Tarr RW, Paras VH, Selman WR, Landis DM (2002) Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke 33:1821–1826PubMedCrossRef Zaidat OO, Suarez JI, Santillan C, Sunshine JL, Tarr RW, Paras VH, Selman WR, Landis DM (2002) Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke 33:1821–1826PubMedCrossRef
Metadaten
Titel
The combined use of mechanical thrombectomy devices is feasible for treating acute carotid terminus occlusion
verfasst von
Jin Soo Lee
Ji Man Hong
Seong-Joon Lee
In Soo Joo
Yong Cheol Lim
Sun Yong Kim
Publikationsdatum
01.04.2013
Verlag
Springer Vienna
Erschienen in
Acta Neurochirurgica / Ausgabe 4/2013
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-013-1649-5

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