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01.04.2010 | Dementias - Original Article

Early disturbances of gamma band dynamics in mild cognitive impairment

verfasst von: Pascal Missonnier, François R. Herrmann, Agnès Michon, Lara Fazio-Costa, Gabriel Gold, Panteleimon Giannakopoulos

Erschienen in: Journal of Neural Transmission | Ausgabe 4/2010

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Abstract

Recent studies have indicated that gamma band oscillations participate in the temporal binding needed for the synchronization of cortical networks involved in short-term memory and attentional processes. To date, no study has explored the temporal dynamics of gamma band in the early stages of dementia. At baseline, gamma band analysis was performed in 29 cases with mild cognitive impairment (MCI) during the n-back task. Based on phase diagrams, multiple linear regression models were built to explore the relationship between the cognitive status and gamma oscillation changes over time. Individual measures of phase diagram complexity were made using fractal dimension values. After 1 year, all cases were assessed neuropsychologically using the same battery. A total of 16 MCI patients showed progressive cognitive decline (PMCI) and 13 remained stable (SMCI). When adjusted for gamma values at lag −2, and −3 ms, PMCI cases displayed significantly lower average changes in gamma values than SMCI cases both in detection and 2-back tasks. Gamma fractal dimension of PMCI cases displayed significantly higher gamma fractal dimension values compared to SMCI cases. This variable explained 11.8% of the cognitive variability in this series. Our data indicate that the progression of cognitive decline in MCI is associated with early deficits in temporal binding that occur during the activation of selective attention processes.

Albe-Fessard D, Tasker R, Yamashiro K, Chodakiewitz J, Dostrovsky J (1986) Comparison in man of short latency averaged evoked potentials recorded in thalamic and scalp hand zones of representation. Electroencephalogr Clin Neurophysiol 65:405–415CrossRefPubMed

Allison T, McCarthy G, Wood CC, Jones SJ (1991) Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings. Brain 114(Pt 6):2465–2503CrossRefPubMed

Babiloni C, Babiloni F, Carducci F, Cincotti F, Vecchio F, Cola B, Rossi S, Miniussi C, Rossini PM (2004) Functional frontoparietal connectivity during short-term memory as revealed by high-resolution EEG coherence analysis. Behav Neurosci 118:687–697CrossRefPubMed

Baddeley A (1992) Working memory. Science 255:556–559CrossRefPubMed

Baddeley A, Emslie H, Nimmo-Smith L (1994) The Doors and People Test: a test of visual and verbal recall and recognition. Thames Valley Test Company, Bury St Edmonds, England

Barberger-Gateau P, Chaslerie A, Dartigues JF, Commenges D, Gagnon M, Salamon R (1992) Health measures correlates in a French elderly community population: the PAQUID study. J Gerontol 47:S88–S95PubMed

Basar-Eroglu C, Brand A, Hildebrandt H, Karolina Kedzior K, Mathes B, Schmiedt C (2007) Working memory related gamma oscillations in schizophrenia patients. Int J Psychophysiol 64:39–45CrossRefPubMed

Bressler SL, Coppola R, Nakamura R (1993) Episodic multiregional cortical coherence at multiple frequencies during visual task performance. Nature 366:153–156CrossRefPubMed

Buschke H, Sliwinski MJ, Kuslansky G, Lipton RB (1997) Diagnosis of early dementia by the Double Memory Test: encoding specificity improves diagnostic sensitivity and specificity. Neurology 48:989–997PubMed

Butters N, Granholm E, Salmon DP, Grant I, Wolfe J (1987) Episodic and semantic memory: a comparison of amnesic and demented patients. J Clin Exp Neuropsychol 9:479–497CrossRefPubMed

Canolty RT, Edwards E, Dalal SS, Soltani M, Nagarajan SS, Kirsch HE, Berger MS, Barbaro NM, Knight RT (2006) High gamma power is phase-locked to theta oscillations in human neocortex. Science 313:1626–1628CrossRefPubMed

Daskalakis ZJ, Farzan F, Barr MS, Rusjan PM, Favalli G, Levinson AJ, Fitzgerald PB (2008) Evaluating the relationship between long interval cortical inhibition, working memory and gamma band activity in the dorsolateral prefrontal cortex. Clin EEG Neurosci 39:150–155PubMed

Deiber MP, Ibanez V, Missonnier P, Herrmann F, Fazio-Costa L, Gold G, Giannakopoulos P (2009) Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI. Neurobiol Aging 30:1444–1452CrossRefPubMed

Demiralp T, Bayraktaroglu Z, Lenz D, Junge S, Busch NA, Maess B, Ergen M, Herrmann CS (2007) Gamma amplitudes are coupled to theta phase in human EEG during visual perception. Int J Psychophysiol 64:24–30CrossRefPubMed

Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, LeBeau FE (2007) Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP). Eur J Neurosci 26:1280–1288CrossRefPubMed

Dwyer J, Feinleib M (1992) Introduction to statistical models for longitudinal observation. In: Dwyer JH, Feinleib M, Lippert P et al (eds) Statistical models for longitudinal studies of health. Oxford University Press, New York, pp 3–47

Engel AK, Fries P, Singer W (2001) Dynamic predictions: oscillations and synchrony in top-down processing. Nat Rev Neurosci 2:704–716CrossRefPubMed

Fan J, McCandliss BD, Fossella J, Flombaum JI, Posner MI (2005) The activation of attentional networks. Neuroimage 26:471–479CrossRefPubMed

Fan J, Byrne J, Worden MS, Guise KG, McCandliss BD, Fossella J, Posner MI (2007) The relation of brain oscillations to attentional networks. J Neurosci 27:6197–6206CrossRefPubMed

Fell J, Fernandez G, Klaver P, Elger CE, Fries P (2003) Is synchronized neuronal gamma activity relevant for selective attention? Brain Res Brain Res Rev 42:265–272CrossRefPubMed

Fitzgibbon SP, Pope KJ, Mackenzie L, Clark CR, Willoughby JO (2004) Cognitive tasks augment gamma EEG power. Clin Neurophysiol 115:1802–1809CrossRefPubMed

Fries P, Nikolic D, Singer W (2007) The gamma cycle. Trends Neurosci 30:309–316CrossRefPubMed

Gardner R Jr, Oliver-Munoz S, Fisher L, Empting L (1981) Mattis Dementia Rating Scale: internal reliability study using a diffusely impaired population. J Clin Neuropsychol 3:271–275CrossRefPubMed

Ghent L (1956) Perception of overlapping and embedded figures by children of different ages. Am J Psychol 69:575–587CrossRefPubMed

Gomez C, Hornero R, Abasolo D, Fernandez A, Poza J (2009) Study of the MEG background activity in Alzheimer’s disease patients with scaling analysis methods. Conf Proc IEEE Eng Med Biol Soc 1:3485–3488

Gruber T, Malinowski P, Muller MM (2004) Modulation of oscillatory brain activity and evoked potentials in a repetition priming task in the human EEG. Eur J Neurosci 19:1073–1082CrossRefPubMed

Haig AR, Gordon E, Wright JJ, Meares RA, Bahramali H (2000) Synchronous cortical gamma-band activity in task-relevant cognition. Neuroreport 11:669–675CrossRefPubMed

Herrmann CS, Demiralp T (2005) Human EEG gamma oscillations in neuropsychiatric disorders. Clin Neurophysiol 116:2719–2733CrossRefPubMed

Homan RW, Herman J, Purdy P (1987) Cerebral location of international 10–20 system electrode placement. Electroencephalogr Clin Neurophysiol 66:376–382CrossRefPubMed

Huang C, Wahlund L, Dierks T, Julin P, Winblad B, Jelic V (2000) Discrimination of Alzheimer’s disease and mild cognitive impairment by equivalent EEG sources: a cross-sectional and longitudinal study. Clin Neurophysiol 111:1961–1967CrossRefPubMed

Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:566–572CrossRefPubMed

Jelic V, Shigeta M, Julin P, Almkvist O, Winblad B, Wahlund LO (1996) Quantitative electroencephalography power and coherence in Alzheimer’s disease and mild cognitive impairment. Dementia 7:314–323PubMed

Jensen O, Colgin LL (2007) Cross-frequency coupling between neuronal oscillations. Trends Cogn Sci 11:267–269CrossRefPubMed

Jeong J (2004) EEG dynamics in patients with Alzheimer’s disease. Clin Neurophysiol 115:1490–1505CrossRefPubMed

Jiang ZY, Zheng LL, Yu EY (2008) EEG coherence characteristics at rest and during a three-level working memory task in normal aging and mild cognitive impairment. Med Sci Monit 14:CR515–CR523PubMed

Kaiser J, Lutzenberger W (2003) Induced gamma-band activity and human brain function. Neuroscientist 9:475–484CrossRefPubMed

Kaiser J, Ripper B, Birbaumer N, Lutzenberger W (2003) Dynamics of gamma-band activity in human magnetoencephalogram during auditory pattern working memory. Neuroimage 20:816–827CrossRefPubMed

Kaiser J, Rahm B, Lutzenberger W (2009) Temporal dynamics of stimulus-specific gamma-band activity components during auditory short-term memory. Neuroimage 44:257–264CrossRefPubMed

Kaplan EF, Goodglass H, Weintraub S (1983) The Boston Naming Test. Lea and Febiger, Philadelphia

Klimesch W (1999) EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Brain Res Rev 29:169–195CrossRefPubMed

Klostermann F, Gobbele R, Buchner H, Curio G (2002) Dissociation of human thalamic and cortical SEP gating as revealed by intrathalamic recordings under muscle relaxation. Brain Res 958:146–151CrossRefPubMed

Koenig T, Prichep L, Dierks T, Hubl D, Wahlund LO, John ER, Jelic V (2005) Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment. Neurobiol Aging 26:165–171CrossRefPubMed

Krause CM, Sillanmaki L, Koivisto M, Saarela C, Haggqvist A, Laine M, Hamalainen H (2000) The effects of memory load on event-related EEG desynchronization and synchronization. Clin Neurophysiol 111:2071–2078CrossRefPubMed

LaBar KS, Gitelman DR, Parrish TB, Mesulam M (1999) Neuroanatomic overlap of working memory and spatial attention networks: a functional MRI comparison within subjects. Neuroimage 10:695–704CrossRefPubMed

Lisman J, Buzsaki G (2008) A neural coding scheme formed by the combined function of gamma and theta oscillations. Schizophr Bull 34:974–980CrossRefPubMed

Llinás R, Ribary U (1992) Rostrocaudal scan in human brain: a global characteristic of the 40-Hz response during sensory input. In: Bassar E, Bullock T (eds) Induced rhythms in the brain. Birkhäuser, Boston, pp 147–154

Lutzenberger W, Ripper B, Busse L, Birbaumer N, Kaiser J (2002) Dynamics of gamma-band activity during an audiospatial working memory task in humans. J Neurosci 22:5630–5638PubMed

Milliken GA, Johnson DE (1984) Designed experiments. Van Nostrand Reinhold, New York

Milner B (1971) Interhemispheric differences in the localization of psychological processes in man. Br Med Bull 27:272–277PubMed

Missonnier P, Gold G, Herrmann FR, Fazio-Costa L, Michel JP, Deiber MP, Michon A, Giannakopoulos P (2006) Decreased theta event-related synchronization during working memory activation is associated with progressive mild cognitive impairment. Dement Geriatr Cogn Disord 22:250–259CrossRefPubMed

Missonnier P, Deiber MP, Gold G, Herrmann FR, Millet P, Michon A, Fazio-Costa L, Ibanez V, Giannakopoulos P (2007) Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment. Neuroscience 150:346–356CrossRefPubMed

Mitrushina M, Satz P, Chervinsky A, D’Elia L (1991) Performance of four age groups of normal elderly on the Rey Auditory–Verbal Learning Test. J Clin Psychol 47:351–357CrossRefPubMed

Naatanen R, Alho K (1995) Mismatch negativity—a unique measure of sensory processing in audition. Int J Neurosci 80:317–337CrossRefPubMed

Pantev C, Makeig S, Hoke M, Galambos R, Hampson S, Gallen C (1991) Human auditory evoked gamma-band magnetic fields. Proc Natl Acad Sci USA 88:8996–9000CrossRefPubMed

Petersen RC, Morris JC (2005) Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol 62:1160–1163 (discussion 1167)CrossRefPubMed

Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B (2001) Current concepts in mild cognitive impairment. Arch Neurol 58:1985–1992CrossRefPubMed

Poeck K (1985) Clues to the nature of disruption to limb praxis. In: Roy EA (ed) In neuropsychological studies of apraxia and related disorders. Elsevier, North-Holland, Amsterdam, pp 99–109

Reitan RM (1958) Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills 8:271–276CrossRef

Ribary U, Llinas R, Kluger A, Suk J, Ferris SH (1989) Neuropathological dynamics of magnetic, auditory, steady-state responses in Alzheimer’s disease. In: Williamson SJ, Hoke M, Stroink G et al (eds) Advances in biomagnetism. Plenum Press, New York, pp 311–314

Ribary U, Llinas R, Kluger A, Cappell J, Suk J, Ferris SH (1990) Dynamics of magnetic, auditory evoked steady-state responses in Alzheimer patients. Electroencephalogr Clin Neurophysiol 75:S126

Ribary U, Ioannides AA, Singh KD, Hasson R, Bolton JP, Lado F, Mogilner A, Llinas R (1991) Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. Proc Natl Acad Sci USA 88:11037–11041CrossRefPubMed

Rodriguez E, George N, Lachaux JP, Martinerie J, Renault B, Varela FJ (1999) Perception’s shadow: long-distance synchronization of human brain activity. Nature 397:430–433CrossRefPubMed

Rossini PM, Del Percio C, Pasqualetti P, Cassetta E, Binetti G, Dal Forno G, Ferreri F, Frisoni G, Chiovenda P, Miniussi C, Parisi L, Tombini M, Vecchio F, Babiloni C (2006) Conversion from mild cognitive impairment to Alzheimer’s disease is predicted by sources and coherence of brain electroencephalography rhythms. Neuroscience 143:793–803CrossRefPubMed

Ruusuvirta T, Huotilainen M (2005) The fast detection of rare auditory feature conjunctions in the human brain as revealed by cortical gamma-band electroencephalogram. Neuroscience 130:91–94CrossRefPubMed

Salinas E, Sejnowski TJ (2001) Correlated neuronal activity and the flow of neural information. Nat Rev Neurosci 2:539–550CrossRefPubMed

Schneider TR, Debener S, Oostenveld R, Engel AK (2008) Enhanced EEG gamma-band activity reflects multisensory semantic matching in visual-to-auditory object priming. Neuroimage 42:1244–1254CrossRefPubMed

Schnider A, Hanlon RE, Alexander DN, Benson DF (1997) Ideomotor apraxia: behavioral dimensions and neuroanatomical basis. Brain Lang 58:125–136CrossRefPubMed

Simons DJ, Carvell GE, Kyriazi HT, Bruno RM (2007) Thalamocortical conduction times and stimulus-evoked responses in the rat whisker-to-barrel system. J Neurophysiol 98:2842–2847CrossRefPubMed

Singer W (2009) Distributed processing and temporal codes in neuronal networks. Cogn Neurodyn 3:189–196CrossRefPubMed

Stam CJ (2005) Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. Clin Neurophysiol 116:2266–2301CrossRefPubMed

Stam CJ, van Walsum AM, Pijnenburg YA, Berendse HW, de Munck JC, Scheltens P, van Dijk BW (2002) Generalized synchronization of MEG recordings in Alzheimer’s disease: evidence for involvement of the gamma band. J Clin Neurophysiol 19:562–574CrossRefPubMed

Stam CJ, van der Made Y, Pijnenburg YA, Scheltens P (2003) EEG synchronization in mild cognitive impairment and Alzheimer’s disease. Acta Neurol Scand 108:90–96CrossRefPubMed

Stam CJ, Jones BF, Manshanden I, van Walsum AM, Montez T, Verbunt JP, de Munck JC, van Dijk BW, Berendse HW, Scheltens P (2006) Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer’s disease. Neuroimage 32:1335–1344CrossRefPubMed

Tallon-Baudry C, Bertrand O (1999) Oscillatory gamma activity in humans and its role in object representation. Trends Cogn Sci 3:151–162CrossRefPubMed

Tallon-Baudry C, Bertrand O, Peronnet F, Pernier J (1998) Induced gamma-band activity during the delay of a visual short-term memory task in humans. J Neurosci 18:4244–4254PubMed

Tao HY, Tian X (2005) Coherence Characteristics of Gamma-band EEG during rest and cognitive task in MCI and AD. Conf Proc IEEE Eng Med Biol Soc 3:2747–2750PubMed

Teipel SJ, Pogarell O, Meindl T, Dietrich O, Sydykova D, Hunklinger U, Georgii B, Mulert C, Reiser MF, Möller HJ, Hampel H (2008) Regional networks underlying interhemispheric connectivity: an EEG and DTI study in healthy ageing and amnestic mild cognitive impairment. Hum Brain Mapp 30:2098–2119

Uhlhaas PJ, Haenschel C, Nikolic D, Singer W (2008) The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr Bull 34:927–943CrossRefPubMed

van Deursen JA, Vuurman EF, Verhey FR, van Kranen-Mastenbroek VH, Riedel WJ (2008) Increased EEG gamma band activity in Alzheimer’s disease and mild cognitive impairment. J Neural Transm 115:1301–1311CrossRefPubMed

Varela F, Lachaux JP, Rodriguez E, Martinerie J (2001) The brainweb: phase synchronization and large-scale integration. Nat Rev Neurosci 2:229–239CrossRefPubMed

Wechsler D (1981) Adult Intelligence Scale, Revised (WAIS-R). Psychological Corporation, San Antonio

Welsh KA, Butters N, Mohs RC, Beekly D, Edland S, Fillenbaum G, Heyman A (1994) The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology 44:609–614PubMed

Wolf H, Jelic V, Gertz HJ, Nordberg A, Julin P, Wahlund LO (2003) A critical discussion of the role of neuroimaging in mild cognitive impairment. Acta Neurol Scand Suppl 179:52–76CrossRefPubMed

Wright JJ, Robinson PA, Rennie CJ, Gordon E, Bourke PD, Chapman CL, Hawthorn N, Lees GJ, Alexander D (2001) Toward an integrated continuum model of cerebral dynamics: the cerebral rhythms, synchronous oscillation and cortical stability. Biosystems 63:71–88CrossRefPubMed

Yetkin FZ, Rosenberg RN, Weiner MF, Purdy PD, Cullum CM (2006) FMRI of working memory in patients with mild cognitive impairment and probable Alzheimer’s disease. Eur Radiol 16:193–206CrossRefPubMed

Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370CrossRefPubMed

Titel: Early disturbances of gamma band dynamics in mild cognitive impairment
verfasst von: Pascal Missonnier
François R. Herrmann
Agnès Michon
Lara Fazio-Costa
Gabriel Gold
Panteleimon Giannakopoulos
Publikationsdatum: 01.04.2010
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 4/2010
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-010-0384-9

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