nach oben

Journal of Neural Transmission

Erschienen in:

01.11.2013 | Translational Neurosciences - Original Article

Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria

verfasst von: Makoto Naoi, Wakako Maruyama, Hong Yi

Erschienen in: Journal of Neural Transmission | Ausgabe 11/2013

Einloggen, um Zugang zu erhalten

Abstract

Rasagiline protects neuronal cells from cell death caused by various lines of insults. Its neuroprotective function is due to suppression of mitochondrial apoptosis signaling and induction of neuroprotective genes, including Bcl-2 and neurotrophic factors. Rasagiline inhibits the mitochondrial membrane permeabilization, an initial stage in apoptosis, but the mechanism has been elusive. In this paper, it was investigated how rasagiline regulates mitochondrial death cascade in apoptosis induced in SH-SY5Y cells by PK11195, a ligand of the outer membrane translocator protein of 18 kDa. Rasagiline prevented release of cytochrome c (Cyt-c), and the following caspase 3 activation, ATP depletion and apoptosis, but did not inhibit the mitochondrial membrane potential collapse, in contrast to Bcl-2 overexpression. Rasagiline stabilized the mitochondrial contact site and suppressed Cyt-c release into cytoplasm, which should be the critical point for the regulation of apoptosis. Monoamine oxidase was not associated with anti-apoptotic activity of rasagiline in PK11195-induced apoptosis.

Akao Y, Maruyama W, Shimizu S et al (2002) Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. J Neurochem 82:913–923PubMedCrossRef

Anholt RRH, Pedersen L, De Souza EB, Snyder SH (1986) The peripheral-type benzodiazepine receptor. J Biol Chem 261:576–583PubMed

Binda C, Hubalek F, Li M, Herzig Y, Sterling J, Edmondson DE, Mattevi A (2005) Binding of rasagiline-related inhibitors to human monoamine oxidases; a kinetic and crystallographic analysis. J Med Chem 48:8148–8154PubMedCrossRef

Blandini F, Armentero MT, Fancellu R, Blaugrund E, Nappi G (2004) Neuroprotective effect of rasagiline in a rodent model of Parkinson’ disease. Exp Neurol 187:455–459PubMedCrossRef

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein dye binding. Anal Biochem 72:248–254PubMedCrossRef

De Marchi U, Pietrangeli P, Marcocci L, Mondovi B, Toninello A (2003) l-Deprenyl as an inhibitor of menadione-induced permeability transition in liver mitochondria. Biochem Pharmacol 66:1749–1754PubMedCrossRef

Doran E, Halestrap AP (2000) Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites. Biochem J 348:343–350PubMedCrossRef

Ebadi M, Brown-Borg H, Ren J, Sharma S, Shavali S, ReFacy HE, Carlson EC (2006) Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Curr Drug Targets 7:1513–1529PubMedCrossRef

Eckert A, Steiner B, Marques C, Leutz S, Roming H, Hass C, Muller WE (2001) Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. N Neurosci Res 64:183–192CrossRef

Enari M, Hase A, Nagata S (1995) Apoptosis by a cytosolic extract from Fas-activated cells. EMBO J 14:5201–5208PubMed

Garrido C, Galluzzi L, Brunet M, Puig PE, Didelot C, Kroemer G (2006) Mechanism of cytochrome c release from mitochondria. Cell Death Differ 13:1423–1433PubMedCrossRef

Gavish M, Bachman I, Shoukrun R, Katz Y, Veenman L, Weisingwe G, Weizman A (1999) Enigma of the peripheral benzodiazepine receptor. Pharmacol Rev 51:629–650PubMed

Gonzalez-Polo R, Carvalho G, Braun T et al (2005) PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepine receptor. Oncogene 24:7503–7513PubMedCrossRef

Green DR, Kroemer G (2004) The pathophysiology of mitochondrial cell death. Science 305:626–629PubMedCrossRef

Grimm S, Brdiczka D (2007) The permeability transition pore in cell death. Apoptosis 12:841–855PubMedCrossRef

Hong-Rong XIE, Lin-Sen HU, Guo-Yi LI (2010) SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson’s disease. Chin Med 123:1086–1092

Hubalek F, Binda C, Ki M, Herzig Y, Sterling J, Youdim MBH, Mattevi A, Edmondson DE (2004) Inactivation of purified human recombinant monoamine oxidase A and B by rasagiline and its analogues. J Med Chem 47:1760–1768PubMedCrossRef

Inaba-Hasegawa K, Akao Y, Maruyama W, Naoi M (2012) Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase. J Neural Transm 119:405–414PubMedCrossRef

Inaba-Hasegawa K, Akao Y, Maruyama W, Naoi M (2013) Rasagiline and selegiline, inhibitors of type B monoamine oxidase, induce type A monoamine oxidase in human SH-SY5Y cells. J Neural Transm 120:435–444PubMedCrossRef

Kinnally KW, Antinsson B (2007) A tale of two mitochondrial channels, MAC and PTP, in apoptosis. Apoptosis 12:857–868PubMedCrossRef

Kowaltowski AJ, Fiskum G (2005) Redox Mechanisms of cytoprotection by Bcl-2. Antioxid Redox Signal 7:508–514PubMedCrossRef

Kraml M (1965) A rapid microfluorometric determination of monoamine oxidase. Biochem Pharmacol 14:1684–1686CrossRef

Kupsch A, Sautter J, Götz ME et al (2001) Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP1012) with selegiline. J Neural Transm 108:985–1009PubMedCrossRef

Lai CT, Yu PH (1997) R(−)-deprenyl potentiates dopamine-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Appl Pharmacol 142:186–191CrossRef

Lambert AJ, Brand MD (2004) Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH: ubiquinone oxidoreductase (complex I). J Biol Chem 279:39414–39420PubMedCrossRef

Lamensdorf I, Youdim MBH, Finberg JPM (1996) Effect of long-term treatment with selective monoamine oxidase A and B inhibitors on dopamine release from rat striatum. J Neurochem 67:1532–1539PubMedCrossRef

Lee CS, Lee CS, Ko HH, Song JH, Han ES (2002) Effect of R-(−)-deprenyl and harmaline on dopamine- and peroxynitrite-induced membrane permeability transition in brain mitochondria. Neurochem Res 27:215–224PubMedCrossRef

Maaser K, Sutter AP, Scherübl H (2005) Mechanisms of mitochondrial apoptosis induced by benzodiazepine receptor ligands in human colorectal cancer cells. Biochem Biophys Res Commun 332:646–652PubMedCrossRef

Mangan PS, Colombini M (1987) Ultrasteep voltage dependence in a membrane channel. Proc Natl Acad Sci USA 84:4896–4900PubMedCrossRef

Maruyama W, Naoi M (2013) “70th Birthday Professor Riederer” Induction of glial cell-line-derived and brain-derived neurotrophic factors by rasagiline and (−)deprenyl: a way to a disease-modifying therapy? J Neural Transm 120:83–89PubMedCrossRef

Maruyama W, Strolin Benedett M, Takahasi T, Naoi M (1997) A neurotoxin, N-methyl(R)salsolinol induces apoptosis in human differentiated dopaminergic neuroblastoma SH-SY5Y cells. Neurosci Lett 237:147–150CrossRef

Maruyama W, Akao Y, Youdim M, Naoi M (2000) Neurotoxin induced apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, Rasagiline and TV1022. J Neural Transm 60(Suppl):171–186

Maruyama W, Akao Y, Youdim MBH, Davis BA, Naoi M (2001) Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehydes-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol. J Neurochem 78:727–735PubMedCrossRef

Maruyama W, Takahashi T, Youdim M, Naoi M (2002) The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells. J Neural Transm 109:467–481PubMedCrossRef

Maruyama W, Nitta A, Shamoto-Nagai M et al (2004) N-propargyl-1(R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor. Neurochem Int 44:393–400PubMedCrossRef

Mazzulli JR, Mishizen AJ, Giasson BI et al (2006) Cytosolic catechols inhibit a-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J Neurosci 26:1068–10078CrossRef

Murphy AN, Bredesen DE, Cortopassi G, Wang E, Fiskum G (1996) Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc Natl Acad Sci USA 93:9893–9898PubMedCrossRef

Naoi M, Maruyama W (2010) Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders. Curr Pharm Design 16:2799–2817CrossRef

Naoi M, Maruyama W, Akao Y, Zhang J, Parvez H (2000) Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons. Toxicology 153:123–141PubMedCrossRef

Naoi M, Maruyama W, Inaba-Hasegawa K, Akao Y (2011) Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection. Int Rev Neurobiol 100:85–106PubMedCrossRef

Naoi M, Maruyama W, Inaba-Hasegawa K (2013) Revelation in neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms. Expert Rev Neurother (in press)

Olanow CW, Rascol O, Hauser R et al (2009) A double-blind, delayed-start trial of rasagiline in Parkinson’s disease. N Eng J Med 361:1268–1278CrossRef

Olson JM, McNeed W, Young AB, Mancini WR (1992) Localization of peripheral-type benzodiazepine binding site to mitochondria of human glioma cells. J Neurosci 13:35–42

Riederer P, Laux G (2011) MAO-inhibitors in Parkinson’s disease. Exp Neurobiol 20:1–17PubMedCrossRef

Schwarz M, Andrade-Navarro M, Gross A (2007) Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program? Apoptosis 12:869–876PubMedCrossRef

Seleikyte J, Petronilli V, Zulian A et al (2011) Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor). J Biol Chem 28:1046–1053CrossRef

Shimizu S, Narita M, Tsujimoto Y (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399:483–487PubMedCrossRef

Speiser Z, Mayk A, Litinetsky L, Fine T, Nyska A, Blaugrund E, Cohen S (2007) Rasagiline is neuroprotective in an experimental model of brain ischemia in the rat. J Neural Transm 114:595–605PubMedCrossRef

Tatton WG, Chalmers-Redman RME, Ju WJH et al (2002) Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells. J Pharmacol Exp Ther 301:753–764PubMedCrossRef

Tsujimoto Y, Shimizu S (2000) VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ 7:1174–1181PubMedCrossRef

Veeman L, Alten J, Linnemannstöns K et al (2010) Potential involvement of FF1-ATP(syth)ase and reactive oxygen species in apoptosis induction in the antineoplastic agent erucylphosphohomocholine in glioblastoma cell lines. Apoptosis 15:753–768CrossRef

Weireb O, Bar-Am O, Amit T, Chillag-Talmor O, Youdim MBH (2004) Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members. FASEB J 18:1471–1473

Wicker U, Bucheler K, Gellerich FN, Wagner M, Kapischke M, Brdiczka D (1993) Effect of macromolecules on the structure of the mitochondrial intermembrane space and the regulation of hexokinase. Biochim Biophys Acta 1142:228–239PubMedCrossRef

Yi H, Akao Y, Maruyama W, Chen K, Shih J, Naoi M (2006) Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells. J Neurochem 96:541–549PubMedCrossRef

Youdim MBH, Edmondson D, Tipton KF (2006) The therapeutic potential of monoamine oxidase inhibitors. Nat Rev Neurosci 7:295–309PubMedCrossRef

Titel: Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria
verfasst von: Makoto Naoi
Wakako Maruyama
Hong Yi
Publikationsdatum: 01.11.2013
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 11/2013
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-013-1033-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

25.04.2024 | Hypotonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Rasagiline prevents apoptosis induced by PK11195, a ligand of the outer membrane translocator protein (18 kDa), in SH-SY5Y cells through suppression of cytochrome c release from mitochondria

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2013

Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

Cognitive effects of deep brain stimulation for essential tremor: evaluation at 1 and 6 years

Cerebrospinal fluid levels of chromogranin A in the treatment-naïve early stage Parkinson’s disease: a pilot study

Effect and safety of duodenal levodopa infusion in advanced Parkinson’s disease: a retrospective multicenter outcome assessment in patient routine care

Genetic association between APOA1 and APOD polymorphisms and Alzheimer’s disease in a Japanese population

Postweaning social isolation exacerbates neurotoxic effects of the NMDA receptor antagonist MK-801 in rats

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie